Thiol-disulfide homoestasis in pregnancies with fetal growth restriction

Cakar, Erbil; Ayvaci, Habibe; Karçaaltıncaba, Deniz; Aydın, Gültekin Adanaş; Cilli, Asli; Bıçer, Cemile; Erel, Özcan; Eser, S

doi:10.1080/14767058.2018.1480603

Cited by 8 publications

(9 citation statements)

References 20 publications

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“…Cetin et al [14] compared the thiol-disulfide homeostasis between pregnancies with IUGR and a control group of healthy, pregnant women in their study and reported that total thiol and native thiol levels were low, but disulfide levels were the same as compared to the control group. Cakar et al [13] conducted a study to compare the total thiol, native thiol, disulfide, native thiol/total thiol, disulfide/native thiol, and disulfide/total thiol values in pregnancies with IUGR with a group of healthy, pregnant women. They divided the group of pregnant women with IUGR into two subgroups, i.e., the group with idiopathic IUGR and the group with IUGR coexisting with preeclampsia.…”

Section: Discussionmentioning

confidence: 99%

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Urotensin 2 and Oxidative Stress Levels in Maternal Serum in Pregnancies Complicated by Intrauterine Growth Restriction

et al. 2019

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Background and objectives: In this study, the aim was to investigate Urotensin 2 (U-II) levels and oxidant/antioxidant system parameters in pregnancies with intrauterine growth restriction (IUGR). Materials and Methods: A total of 36 healthy, pregnant women who had not been diagnosed with IUGR and 36 pregnant women who had been diagnosed with IUGR at the Obstetrics and Gynecology Outpatient Clinic at Gaziantep University Hospital were enrolled in this study. The serum total antioxidant status (TAS), total oxidant status (TOS), thiol-disulfide levels, U-II measurements, and oxidative stress index (OSI) calculations were carried out at the biochemistry laboratory at Gaziantep University. Results: According to this study, there was no statistically significant difference between the group with IUGR and the control group of healthy, pregnant women in terms of total antioxidant status (TAS), total oxidant status (TOS), oxidative stress index (OSI), native thiol, total thiol, disulfide, disulfide/native thiol, disulfide/total thiol, native thiol/total thiol, and U-II values. There was, however, a positive linear correlation between TOS and total thiol levels in the group with IUGR (p = 0.021, r = 0.384), and a positive linear correlation between OSI and total thiol values in the control group (p = 0.049, r = 0.330). In addition, there was a negative correlation between disulfide levels and gestational weeks at birth in the group with IUGR (p = 0.027, r = 0.369). Conclusions: Consequently, there was no significant difference between the control group and the group with pregnancies complicated by idiopathic IUGR in terms of serum oxidant/antioxidant system parameters and U-II levels. It is necessary to conduct more extensive studies evaluating placental, maternal, and fetal oxidative stress in conjunction in order to investigate the role of oxidative stress in IUGR.

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Section: Discussionmentioning

confidence: 99%

“…Antioxidant enzymes, including their activity and overall levels, and the total oxidant or antioxidant status have been studied previously [13,14]. However, serum U-II levels and markers of the antioxidant system have not previously been investigated in the same patients at the same time.…”

Section: Introductionmentioning

confidence: 99%

Urotensin 2 and Oxidative Stress Levels in Maternal Serum in Pregnancies Complicated by Intrauterine Growth Restriction

et al. 2019

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“…Oxidative stress is related to many diseases and the thiolmediated antioxidant system was found to be weakened in obstetric complications such as fetal growth retardation, preeclampsia, premature ovarian failure, hyperemesis gravidarum (16)(17)(18). Antioxidant effect and thiol, which is a part of cysteine amino acid, play a significant role in preventing oxidative stress in the cell (19).…”

Section: Discussionmentioning

confidence: 99%

“…Preservation of antioxidant balance and oxidative stress are important for a variety of benign and malignant conditions such as diabetes mellitus and the familial Mediterranean fever as well as for uterine fibroids (16,(29)(30)(31). Relationship between oxidative stress and uterine fibroids was demonstrated in studies regarding surgically removed leiomyomas and found clear interaction between mainly by lipid peroxidation and leiomyoma (32).…”

Section: Inhibition Of Oxidative Stress In the Cell By Amino Acids Anmentioning

confidence: 99%

Level of Certain Oxidants and Antioxidants in Patients with Uterine Fibroids

Çetinkaya

Ayral

Çeti̇nkaya

et al. 2019

Gynecol Obstet Reprod Med

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Objective: The mechanism of the leiomyoma formation process is still unknown. However, the menstrual cycle is associated with hypoxia, and ongoing hypoxia is associated with cellular events leading to the conversion of myometrial cells into uterine fibroids. After the hypoxic environment, the balance of cellular cytokines and growth factors changes. It was planned to evaluate the balance of oxidative agents and the role of oxidative stress in the formation of uterine fibroids.Study Design: The study was conducted in patients of gynecology outpatient clinic of Ankara Oncology Training and Research Hospital. Those volunteers with fibroids formed the study group, and the healthy ones were identified as the control group. A total of 64 subjects, 32 in both groups were included. The levels of catalase, ceruloplasmin, myeloperoxidase, native thiol, disulfide, and total thiol levels were investigated in groups.Results: Antioxidant parameters such as native thiol, disulfide, and total thiol levels were significantly decreased in uterine fibroid group. Catalase, ceruloplasmin, and myeloperoxidase levels were not statistically different between groups.Conclusion: Decrease in these antioxidant parameters showed that the hypoxia and the balance of oxidant and antioxidant substances changes may probably have associated with the pathophysiology of uterine fibroids.

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“…In the literature, there are studies evaluating the levels of TDH and IMA in pregnancy complications such as gestational diabetes, hyperemesis gravidarum, PE, and intrauterine growth retardation ( 9 , 15 , 16 , 17 ) . Because PE remains an important obstetric complication, there have been ongoing studies on the biochemical markers for the early detection of this disease.…”

Section: Introductionmentioning

confidence: 99%

The relationship between oxidative stress and preeclampsia. The serum ischemia-modified albumin levels and thiol/disulfide homeostasis

Onat¹,

Kırmızı²,

Başer³

et al. 2020

tjod

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Objective: Preeclampsia (PE) is a dangerous complication of pregnancy and still a major cause of maternal-fetal morbidity and mortality. Its etiology remains largely unknown, but researchers have suggested oxidative stress-mediated inflammation for the same. The purpose of this study is to investigate the relationship between oxidative stress and PE as well as the usability of oxidative stress indicators such as serum ischemia-modified albumin (IMA) levels and thiol/disulfide balance in the prediction of PE. Materials and Methods: The study included 47 pregnant women with PE and 57 healthy pregnant women. We measured their serum IMA, native thiol, total thiol, and disulfide levels. Additionally, we determined the optimal cutoff values via the receiver operating characteristic curve analysis. Results: There were no differences between the two groups with respect to the maternal age, body mass index, gravida, and parity. The native and total thiol levels were found to be low when the disulfide and IMA levels were high in the patients with PE (p<0.05). When the IMA level was corrected by the albumin level (IMAR), the significant difference between the two groups disappeared. We also found that the native and total thiol concentrations were correlated with the systolic and diastolic blood pressures. The optimal cut-off values calculated for the prediction of PE were as follows: 178.45 µmol/L (with sensitivity of 72% and specificity of 83%) for native thiol, 232.55 µ mol/L (with a sensitivity of 75% and specificity of 85%) for total thiol, and 29.05 µmol/L (with sensitivity of 65% and specificity of 72%) for disulfide. Conclusion: The balance of thiol/disulfide may play a role in the pathogenesis of PE and could be used as a biological marker for PE.

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Thiol-disulfide homoestasis in pregnancies with fetal growth restriction

Cited by 8 publications

References 20 publications

Urotensin 2 and Oxidative Stress Levels in Maternal Serum in Pregnancies Complicated by Intrauterine Growth Restriction

Urotensin 2 and Oxidative Stress Levels in Maternal Serum in Pregnancies Complicated by Intrauterine Growth Restriction

Level of Certain Oxidants and Antioxidants in Patients with Uterine Fibroids

The relationship between oxidative stress and preeclampsia. The serum ischemia-modified albumin levels and thiol/disulfide homeostasis

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