Level of Certain Oxidants and Antioxidants in Patients with Uterine Fibroids

Abstract

<p><strong>Objective:</strong> The mechanism of the leiomyoma formation process is still unknown. However, the menstrual cycle is associated with hypoxia, and ongoing hypoxia is associated with cellular events leading to the conversion of myometrial cells into uterine fibroids. After the hypoxic environment, the balance of cellular cytokines and growth factors changes. It was planned to evaluate the balance of oxidative agents and the role of oxidative stress in the formation of uterine fibroids.</p><p><strong>Study Design:</strong> The study was conducted in patients of gynecology outpatient clinic of Ankara Oncology Training and Research Hospital. Those volunteers with fibroids formed the study group, and the healthy ones were identified as the control group. A total of 64 subjects, 32 in both groups were included. The levels of catalase, ceruloplasmin, myeloperoxidase, native thiol, disulfide, and total thiol levels were investigated in groups.</p><p><strong>Results:</strong> Antioxidant parameters such as native thiol, disulfide, and total thiol levels were significantly decreased in uterine fibroid group. Catalase, ceruloplasmin, and myeloperoxidase levels were not statistically different between groups.</p><p><strong>Conclusion:</strong> Decrease in these antioxidant parameters showed that the hypoxia and the balance of oxidant and antioxidant substances changes may probably have associated with the pathophysiology of uterine fibroids.</p>

The Integral Core Nutrient Matrix Causing Uterine Fibroid and the Associated Biochemical Roots

“…The age-stratified design model in serum antioxidants shows a significant reduction in mean concentration levels of GPx, GST, and SOD in groups B, C and E, respectively. The result obtained agrees with other studies [60,61]. The decrease in the concentration levels of these antioxidant enzymes could result from the impairment of these antioxidant enzymes…”

“…In the age-stratified design model for antioxidants activity, Gpx and GSH were conspicuously reduced in the case compared to the age-matched control in group B (26)(27)(28)(29)(30)(31)(32)(33)(34)(35). This corroborates with other studies [60,61]. However, there was a significant increase in the mean concentration level of GST in groups B and C. In contrast, GSH was reduced remarkably in the case of groups C and E. The inconsistencies observed in the antioxidant and elemental results might be due to age, lifestyle and adjuvant taken in advanced age by the elderly [63].…”

“…The concentration values of GPx and GSH were reduced in the tumour patients, in contrast to the high GST concentration level in UF patients. The remarkable change noticed in the UF women in GPx and GSH was consistent with earlier report [60,61]. Thus, the concentration levels of the antioxidant enzymes in UF women in four of the five examined antioxidant markers were low (Figure 3).…”

The effect of slow-release vaginal dinoprostone on maternal and fetal oxidative stress in term pregnancies complicated by oligohydramnios: Prospective cohort study

“…OS has been examined in cases of fibroids, assisted reproduction, pregnancy loss, gestational diabetes, preeclampsia, IUGR, nuchal cord, and fetal death. [9][10][11][12][13][14][15] Thiols (RSH) are a class of organic compounds that can undergo oxidation reactions via oxidants and form disulfide bonds. Under conditions of OS, dynamic thiol/disulfide homeostasis is maintained, and it plays critical roles in antioxidant protection, detoxification, signal transduction, apoptosis, regulation of enzymatic activity, transcription factors, and cellular signaling mechanisms.…”

“…OS has been examined in cases of fibroids, assisted reproduction, pregnancy loss, gestational diabetes, preeclampsia, IUGR, nuchal cord, and fetal death. 9–15…”