Thiol-addition reactions and their applications in thiol recognition

Abstract

Because of the biological importance of thiols, the development of probes for thiols has been an active research area in recent years. In this review, we summarize the results of recent exciting reports regarding thiol-addition reactions and their applications in thiol recognition. The examples reported can be classified into four reaction types including 1,1, 1,2, 1,3, 1,4 addition reactions, according to their addition mechanisms, based on different Michael acceptors. In all cases, the reactions are coupled to color and/or emission changes, although some examples dealing with electrochemical recognition have also been included. The use of thiol-addition reactions is a very simple and straightforward procedure for the preparation of thiol-sensing probes.

An ‘OFF–ON’ fluorescent probe for specially recognize on Cys and its application in bioimaging

“…1D 1 H NMR,13 C NMR, and ESI-MS of the probe The 1 H NMR (300MHz) spectra of the probe in DMSO-d 6.The 13 C NMR (75 MHz) spectra of the probe in DMSO-d 6 .…”

Quantitative determination of uric acid using CdTe nanoparticles as fluorescence probes

“…Water-soluble NPs have found use in analytical chemistry applications for the determination of important biological compounds in the human system and have also been used for the development of biosensors (Dai et al 2014;GeszkeMoritz and Moritz 2013;Liang et al 2014;Nouira et al 2013;Wang et al 2014;Yin et al 2013). Hitherto, biosensor research mainly focused on selected commonly-used substances, such as glucose, choline, and thiol which play an important role in catabolism in the human body (Palanisamy et al 2014;Resch-Genger et al 2008).…”

A highly selective and sensitive ON–OFF–ON fluorescence chemosensor for cysteine detection in endoplasmic reticulum

“…As a well-known thiol-containing amino acid in this family, Cys serves as the building block in protein synthesis, detoxification, and metabolism in live organisms Chen et al, 2013;Chen et al 2013;Li et al, 2009;Das et al, 2012). Alterations in the level of cellular Cys has been implicated with neurotoxicity, and the deficiency of Cys may lead to many syndromes, such as a hematopoiesis decrease, slow growth, hair depigmentation, leucocyte loss, psoriasis and so on (Shiu et al, 2011;Yin et al, 2013;Shao et al, 2011;Zhou et al, 2013;Wang et al, 2014).…”