Thinking outside the cell: how cell-free hemoglobin can potentiate acute lung injury

Bastarache, Julie A.; Roberts, L. Jackson; Ware, Lorraine B.

doi:10.1152/ajplung.00355.2013

Cited by 4 publications

(3 citation statements)

References 17 publications

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“…Intravascular hemolysis leading to circulating plasma cell‐free Hb is a potential cause of oxidative injury both in normal patients and in those with sickle cell disease (SCD) . Plasma cell free Hb has been linked to endothelial dysfunction, nephropathy and renal injury, especially in patients with sickle cell disease, and acute respiratory distress syndrome (ARDS) . However, given the relatively low amounts of hemolysis observed in the RBC units that were leukoreduced by combination method, it is unlikely that the amount of plasma cell‐free Hb would result in endothelial dysfunction, renal damage, or ARDS outside of the setting of massive transfusion.…”

Section: Discussionmentioning

confidence: 99%

A comparison of different methods of red blood cell leukoreduction and additive solutions on the accumulation of neutrophil‐priming activity during storage

et al. 2018

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Section: Discussionmentioning

confidence: 99%

A comparison of different methods of red blood cell leukoreduction and additive solutions on the accumulation of neutrophil‐priming activity during storage

et al. 2018

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“…Alveolar haemorrhage occurs when blood escapes from pulmonary capillaries and leaks into the 57 alveolar spaces (1). Alveolar haemorrhage occurs as a consequence of primary blast lung injury (PBLI), 58 acute respiratory distress syndrome (ARDS) and certain types of pulmonary infection (2) (3) (4).…”

Section: Introduction 56mentioning

confidence: 99%

“…Alveolar hemorrhage occurs when blood escapes from pulmonary capillaries and leaks into the alveolar spaces (1), as a consequence of primary blast lung injury (PBLI), acute respiratory distress syndrome (ARDS), and certain types of pulmonary infection (2)(3)(4). PBLI is characterized by hemorrhagic alveolar regions, due to damage of the alveoli and capillaries by the instantaneous blast wave produced from an explosive device (5).…”

Section: Introductionmentioning

confidence: 99%

Red Blood Cells Elicit Platelet-Dependent Neutrophil Recruitment Into Lung Airspaces

Arnold

Shah

Cleary

et al. 2020

Shock

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Signs of Hemolysis Predict Mortality and Ventilator Associated Pneumonia in Severe Acute Respiratory Distress Syndrome Patients Undergoing Veno-Venous Extracorporeal Membrane Oxygenation

Rezoagli,

Bombino,

Ware

et al. 2024

ASAIO Journal

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Cell-free hemoglobin (CFH) is used to detect hemolysis and was recently suggested to trigger acute lung injury. However, its role has not been elucidated in severe acute respiratory distress syndrome (ARDS) patients undergoing extracorporeal membrane oxygenation (ECMO). We investigated the association of carboxyhemoglobin (COHb) and haptoglobin—two indirect markers of hemolysis—with mortality in critically ill patients undergoing veno-venous ECMO (VV-ECMO) with adjusted and longitudinal models (primary aim). Secondary aims included assessment of association between COHb and haptoglobin with the development of ventilator-associated pneumonia (VAP) and with hemodynamics. We retrospectively collected physiological, laboratory biomarkers, and outcome data in 147 patients undergoing VV-ECMO for severe ARDS. Forty-seven patients (32%) died in the intensive care unit (ICU). Average levels of COHb and haptoglobin were higher and lower, respectively, in patients who died. Higher haptoglobin was associated with lower pulmonary (PVR) and systemic vascular resistance, whereas higher COHb was associated with higher PVR. Carboxyhemoglobin was an independent predictor of VAP. Both haptoglobin and COHb independently predicted ICU mortality. In summary, indirect signs of hemolysis including COHb and haptoglobin are associated with modulation of vascular tone, VAP, and ICU mortality in respiratory ECMO. These findings suggest that CFH may be a mechanism of injury in this patient population.

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Thinking outside the cell: how cell-free hemoglobin can potentiate acute lung injury

Cited by 4 publications

References 17 publications

A comparison of different methods of red blood cell leukoreduction and additive solutions on the accumulation of neutrophil‐priming activity during storage

A comparison of different methods of red blood cell leukoreduction and additive solutions on the accumulation of neutrophil‐priming activity during storage

Red Blood Cells Elicit Platelet-Dependent Neutrophil Recruitment Into Lung Airspaces

Signs of Hemolysis Predict Mortality and Ventilator Associated Pneumonia in Severe Acute Respiratory Distress Syndrome Patients Undergoing Veno-Venous Extracorporeal Membrane Oxygenation

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