Thin‐layer chromatography combined with surface‐enhanced Raman scattering for rapid detection of benzidine and 4‐aminobiphenyl in migration from food contact materials based on gold nanoparticle doped metal‐organic framework

Abstract

In this work, a rapid and sensitive thin‐layer chromatography combined with surface‐enhanced Raman spectroscopy method was established for rapid detection of benzidine and 4‐aminobiphenyl in migration from food contact materials based on Au nanoparticle doped metal‐organic framework. Benzidine and 4‐aminobiphenyl were firstly separated by thin‐layer chromatography to solve the limitation of their overlapping Raman peaks. Then the target molecules were monitored by adding AuNPs/MIL‐101(Cr) on the sample spots. Under the optimum conditions, the concentration of benzidine and 4‐aminobiphenyl can be quantitatively measured in the range of 2.0‐20.0 and1.0‐15.0 μg/L, respectively with good linear relationship, and the limits of detection were 0.21 and 0.23 μg/L, respectively. Furthermore, the developed method was applied to analyze benzidine and 4‐aminobiphenyl in migration of different food contact materials. The recoveries of benzidine and 4‐aminobiphenyl for migration of food contact materials, including paper cups, polypropylene food containers, and polyethylene glycol terephthalate bottles, were 80.6‐116.0 and 80.7‐118% with relative standard deviations of 1.1‐9.1 and 3.1‐9.9%, respectively. Surface‐enhanced Raman scattering detection was performed conveniently in the on‐plate mode without additional elution process. The method shows great potential in rapid monitoring of hazardous substances with overlapping characteristic Raman peaks in food contact materials.

Integrated sample‐pretreatment strategy for separation and enrichment of microplastics and primary aromatic amines in the migration of teabag

“…For example, PAAs as important hazards, have been classified as "potentially carcinogenic to humans" by the World Health Organization and International Agency for Research on Cancer. Up to now, PAAs were commonly found in nylon kitchen utensils [17][18][19], paper cups [20], and multilayer plastic laminates [21]. Therefore, nylon and polyethylene terephthalate (PET) teabags have the possibility of the migration of PAAs.…”

Research progress on sample pretreatment methods for migrating substances from food contact materials

“…The membrane performed a dual function of enriching BPA and enhancing the Raman resonance. Besides, our group [81] also adopted thin‐layer chromatography (TLC) to separate benzidine and 4‐aminobiphenyl before SERS detection (Figure 4). The separation of benzidine and 4‐aminobiphenyl by TLC solved the limitation of their overlapping Raman peaks, which achieved the rapid and simultaneous detection of benzidine and 4‐aminobiphenyl from food container.…”

Review of Thin-Layer Chromatography Tandem with Surface-Enhanced Raman Spectroscopy for Detection of Analytes in Mixture Samples

“…Second, the control experiment is usually developed in the TLC-SERS method, and no SERS signal of molecules of the mobile phase is measured from the TLC plate [ 53 , 54 ]. Following the understanding of the SERS and TLC, we will discuss the application of TLC-SERS in real cases, which include the detection of environmental pollutants [ 55 ], pesticides, food additives [ 12 ], food spoilage, biological sample [ 56 ], and chemical substances. Thereby, we hope TLC-SERS could be effectively applied to detect analytes from practical samples.…”