Thin-film electrode based droplet detection for microfluidic systems

Moiseeva, Evgeniya; Fletcher, Adrian; Harnett, C. K.

doi:10.1016/j.snb.2010.11.028

Cited by 32 publications

(24 citation statements)

References 13 publications

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“…28 Moiseeva et al investigated both two-electrode and three-electrode detection mechanisms. 29 It was stated that a three-electrode differential measurement scheme eliminates the background drift. Additionally, since the size and velocity mutually affect the detection signal, these two parameters cannot be resolved using a two-electrode system.…”

Section: Introductionmentioning

confidence: 99%

Real-time impedimetric droplet measurement (iDM)

et al. 2019

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Section: Introductionmentioning

confidence: 99%

Real-time impedimetric droplet measurement (iDM)

et al. 2019

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“…Electrical detection methods, on the other hand, can be implemented as electrodes on a chip where the output could be measured by microchips and analysed by computers. Two examples of electrical detection are resistive 149 and conductive sensing 150 where the electrodes are in contact with the fluid in the microchannel. The conductivity of the dispersed phase is usually much higher than that of the continuous phase so once the dispersed phase comes into contact with two open electrodes, resistance changes drastically, easily picked up by a microchip.…”

Section: Sensingmentioning

confidence: 99%

Droplet control technologies for microfluidic high throughput screening (μHTS)

2017

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The transition from micro well plate and robotics based high throughput screening (HTS) to chip based screening has already started. This transition promises reduced droplet volumes thereby decreasing the amount of fluids used in these studies. Moreover, it significantly boosts throughput allowing screening to keep pace with the overwhelming number of molecular targets being discovered. In this review, we analyse state-of-the-art droplet control technologies that exhibit potential to be used in this new generation of screening devices. Since these systems are enclosed and usually planar, even some of the straightforward methods used in traditional HTS such as pipetting and reading can prove challenging to replicate in microfluidic high throughput screening (μHTS). We critically review the technologies developed for this purpose in depth, describing the underlying physics and discussing the future outlooks.

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“…Electrical detection, on the other hand, can be achieved via deposition of electrodes onto the desired chip, and as such can easily be extended to multiple sensing sites across a chip. Some examples of electrical detection are microwave sensing 2 , multiplexed electrical sensing 3 , conductive sensing 4 and capacitive sensing [5][6][7] . Resistive and conductive methods offer superior sensitivity but require contact with the droplets which increases the risk of cross-contamination.…”

Section: Introductionmentioning

confidence: 99%

Surface acoustic wave enabled pipette on a chip

et al. 2017

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Mono-disperse droplet formation in microfluidic devices allows the rapid production of thousands of identical droplets and has enabled a wide range of chemical and biological studies through repeat tests performed at pico-to-nanoliter volume samples. However, it is exactly this efficiency of production which has hindered the ability to carefully control the location and quantity of the distribution of various samples on a chip - the key requirement for replicating micro well plate based high throughput screening in vastly reduced volumetric scales. To address this need, here, we present a programmable microfluidic chip capable of pipetting samples from mobile droplets with high accuracy using a non-contact approach. Pipette on a chip (PoaCH) system selectively ejects (pipettes) part of a droplet into a customizable reaction chamber using surface acoustic waves (SAWs). Droplet pipetting is shown to range from as low as 150 pL up to 850 pL with precision down to tens of picoliters. PoaCH offers ease of integration with existing lab on a chip systems as well as a robust and contamination-free droplet manipulation technique in closed microchannels enabling potential implementation in screening and other studies.

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Thin-film electrode based droplet detection for microfluidic systems

Cited by 32 publications

References 13 publications

Real-time impedimetric droplet measurement (iDM)

Real-time impedimetric droplet measurement (iDM)

Droplet control technologies for microfluidic high throughput screening (μHTS)

Surface acoustic wave enabled pipette on a chip

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