Real-time impedimetric droplet measurement (iDM)

Saateh, Abtin; Kalantarifard, Ali; Celik, Oguz Tolga; Asghari, Mohammad Hossein; Serhatlıoğlu, Murat; Elbüken, Çağlar

doi:10.1039/c9lc00641a

Cited by 20 publications

(25 citation statements)

References 42 publications

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“…This allowed the observation of dynamic changes with better controllability and the possibility to integrate additional analytical systems more easily. Another device was reported with the ability to monitor the physical properties of droplets in real-time through impedance measurements . This provides a tool for fine-tuning and characterizing droplet generation.…”

Section: Detectionmentioning

confidence: 99%

Recent Advances in Microfluidic Technology for Bioanalysis and Diagnostics

et al. 2020

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Section: Detectionmentioning

confidence: 99%

Recent Advances in Microfluidic Technology for Bioanalysis and Diagnostics

et al. 2020

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“…The latter detects the thermal variation caused by a droplet flowing inside a microchannel 14 . Electrical-based methods rely on the contrast between the two phases in the electrical properties, measuring the impedance 15 , 16 or capacitance 17 – 20 or current 21 or exploiting microwave-based sensing 22 . However, these solutions require calibrations and are limited by the electrical properties of liquids.…”

Section: Introductionmentioning

confidence: 99%

Real-time precise microfluidic droplets label-sequencing combined in a velocity detection sensor

Zamboni

Zaltron

Chauvet

et al. 2021

Sci Rep

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Droplets microfluidics is broadening the range of Lab on a Chip solutions that, however, still suffer from the lack of an adequate level of integration of optical detection and sensors. In fact, droplets are currently monitored by imaging techniques, mostly limited by a time-consuming data post-processing and big data storage. This work aims to overcome this weakness, presenting a fully integrated opto-microfluidic platform able to detect, label and characterize droplets without the need for imaging techniques. It consists of optical waveguides arranged in a Mach Zehnder’s configuration and a microfluidic circuit both coupled in the same substrate. As a proof of concept, the work demonstrates the performances of this opto-microfluidic platform in performing a complete and simultaneous sequence labelling and identification of each single droplet, in terms of its optical properties, as well as velocity and lengths. Since the sensor is realized in lithium niobate crystals, which is also highly resistant to chemical attack and biocompatible, the future addition of multifunctional stages into the same substrate can be easily envisioned, extending the range of applicability of the final device.

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“…Commonly used sensors in microfluidic applications (both experimental and commercial) rely on optical [5] or electrochemical sensing methods [17,18]. Electrochemical sensors (impedance sensors with coplanar or parallel electrode layouts) can be made compact and low-cost, but have limited spatial resolution and issues with SNR [19].…”

Section: Introductionmentioning

confidence: 99%

Optical Detection Methods for High-Throughput Fluorescent Droplet Microflow Cytometry

et al. 2021

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High-throughput microflow cytometry has become a focal point of research in recent years. In particular, droplet microflow cytometry (DMFC) enables the analysis of cells reacting to different stimuli in chemical isolation due to each droplet acting as an isolated microreactor. Furthermore, at high flow rates, the droplets allow massive parallelization, further increasing the throughput of droplets. However, this novel methodology poses unique challenges related to commonly used fluorometry and fluorescent microscopy techniques. We review the optical sensor technology and light sources applicable to DMFC, as well as analyze the challenges and advantages of each option, primarily focusing on electronics. An analysis of low-cost and/or sufficiently compact systems that can be incorporated into portable devices is also presented.

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Real-time impedimetric droplet measurement (iDM)

Abstract: An impedimetric droplet detection tool for real-time analysis of droplet properties.

Cited by 20 publications

References 42 publications

Recent Advances in Microfluidic Technology for Bioanalysis and Diagnostics

Recent Advances in Microfluidic Technology for Bioanalysis and Diagnostics

Real-time precise microfluidic droplets label-sequencing combined in a velocity detection sensor

Optical Detection Methods for High-Throughput Fluorescent Droplet Microflow Cytometry

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