Thickness of the Macula, Retinal Nerve Fiber Layer, and Ganglion Cell–inner Plexiform Layer in the Age-Related Macular Degeneration

Shin, Il-Hwan; Lee, Woo-Hyuk; Lee, Jongjoo; Jo, Young–Joon; Kim, Jung‐Yeul

doi:10.1097/iae.0000000000001535

Cited by 18 publications

(17 citation statements)

References 35 publications

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“…The overall ICCs for the retinal disease group were lower than those for the normal group using both OCT devices, with the exception of macular thickness using SD-OCT. We found that the low and high CMT groups had ICCs that were lower than those in the normal CMT group using both OCT devices. This trend was consistent with that seen in previous studies comparing normal eyes with eyes affected by retinal disease using SD-OCT.[20, 21, 29] Lee et al reported that the ICCs for thickness measurements in groups with normal eyes, eyes with macular edema, and eyes with atrophy were 0.998, 0.985, and 0.903, respectively. Our data also showed high repeatability for macular thickness measurements (ICC > 0.8–0.9 on both OCT devices).…”

Section: Discussionsupporting

confidence: 91%

“…Shin et al also reported that repeatability of SD-OCT for GC-IPL measurements was low in eyes with AMD that were out of the normal CMT range. [29] In the present study, retinal diseases were classified by CMT rather than by specific disease because of the small sample sizes. Further studies are warranted to confirm the repeatability of SS-OCT for each specific retinal disease.…”

Section: Discussionmentioning

confidence: 99%

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Comparison of repeatability of swept-source and spectral-domain optical coherence tomography for measuring inner retinal thickness in retinal disease

et al. 2019

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PurposeTo compare repeatability between SS-OCT and SD-OCT for measurement of macular, macular retinal nerve fiber (mRNFL), and ganglion cell-inner plexiform layer (GC-IPL) thickness in various retinal diseases.MethodsOne hundred and fourteen eyes of 114 subjects were investigated. Seventy-eight eyes with retinal disease and 36 normal eyes underwent two consecutive measurements of macular, mRNFL, and GC-IPL thickness using SS-OCT and SD-OCT. The data were obtained using the Early Treatment Diabetic Retinopathy Study (ETDRS) protocol. The eyes with retinal diseases were divided into three subgroups according to central macular thickness (CMT) for analysis. The intraclass correlation coefficient (ICC) was calculated to determine the repeatability of OCT device.ResultsIn normal eyes, both OCT devices showed excellent repeatability of macula, mRNFL, and GC-IPL thickness measurements with high ICCs in all ETDRS subfields. In eyes with retinal disease, although SS-OCT showed better repeatability for inner retinal thickness measurements than SD-OCT, the overall ICCs were lower than those in normal eyes. In subgroup analysis, the ICCs in the low CMT group were lower than those in the normal and high CMT groups, particularly when using SD-OCT.ConclusionsBoth OCT devices had comparable repeatability for retinal thickness measurement in normal eyes and eyes with retinal disease. However, the possibility of measurement error should be considered in eyes with a thin and atrophic retina.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Comparison of repeatability of swept-source and spectral-domain optical coherence tomography for measuring inner retinal thickness in retinal disease

et al. 2019

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“…However, using multivariate analyses, the GC-IPL was not significant (p = 0.877). In eyes with macular edema, OCTA tends to measure a thinner GCIPL thickness than the actual thickness because of segmentation error [18,19]. Therefore, the impact of the actual GCIPL thickness on the repeatability of OCTA might have been diminished; additional studies are needed to prove this hypothesis.…”

Section: Plos Onementioning

confidence: 99%

Repeatability of measuring the vessel density in patients with retinal vein occlusion: An optical coherence tomography angiography study

et al. 2020

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To determine the repeatability of superficial vessel density measurements using Spectral domain Ocular coherence tomography angiography(SD-OCTA) in patients diagnosed with retinal vein occlusion(RVO). Design Prospective observational study. Subjects Patients who visited our retinal clinic from August 2017 to August 2018, diagnosed with RVO were recruited for the study. Methods Two consecutive 3×3 mm pattern scans were performed using the Cirrus HD-OCT 5000 along with AngioPlex software (Carl Zeiss Meditec) in each eye by single skilled examiner. All scans were analyzed using en face OCTA images to measure vessel density (VD) automatically. For further analysis of the effect of central macular thickness(CMT), eyes were divided into two groups according to CMT of 400μm (Group 1: CMT > 400μm, Group 2: CMT < 400μm). To identify factors affecting the repeatability of VD measurements, linear regression analyses were conducted for the coefficient of variation (CV) of VD by investigating demographics and ocular variables. Main outcome measures The intraclass correlation coefficient (ICC), coefficient of variation (CV) of VD measurements.

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“…AMD predominantly involves the outer retinal layers, where extracellular accumulation of lipoprotein in drusen is associated with photoreceptor loss and thinning of the outer nuclear layer. However, inner retinal layers, including the vascularized layers, such as the retinal nerve fibre, ganglion cell, inner plexiform, inner nuclear, and outer plexiform layers may also be involved following photoreceptor degeneration [2,3]. Recent classification of early AMD differentiates lipoprotein extracellular accumulations in drusen localized below the retinal pigment epithelium from subretinal drusenoid deposits (SDD) localized above the retinal pigment epithelium [4][5][6].…”

Section: Introductionmentioning

confidence: 99%

“…The pathogenesis of SDD, otherwise called reticular pseudodrusen, is not completely understood, however, numerous authors have found a reduction of choroidal thickness [5,6,11,12]. The ganglion cell-inner plexiform layer (GCL)-(IPL) has been reported to be thinner in AMD [2], but this layer has not been studied in eyes with SDD. The vascularized retinal layers correlate positively with choroidal thickness in normal eyes [13], owing to this correlation, the present study aimed to evaluate both the choroidal and macular GCL-IPL thicknesses in the presence of SDD in an attempt to further understand the pathogenetic mechanisms involved.…”

Section: Introductionmentioning

confidence: 99%

Optical coherence tomography evidence of macular ganglion cell-inner plexiform layer thinning in eyes with subretinal drusenoid deposits

Abdolrahimzadeh

Parisi

Marcelli

et al. 2019

Eye

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Background/Objectives The purpose of this study was to evaluate macular ganglion cell layer-inner plexiform layer (GCL-IPL) and choroidal thickness in early age-related macular degeneration (AMD) in eyes with subretinal drusenoid deposits (SDD). Subjects/Methods Comprehensive ophthalmological examination was performed. Near infrared reflectance and raster images using enhanced depth imaging were acquired with spectral domain optical coherence tomography. Drusen and SDD were diagnosed based on raster scans and near infrared reflectance. GCL-IPL maps were generated with automated segmentation and choroidal thickness maps were obtained by manually delineating the choroid-scleral boundary. Results Forty-eight eyes from 48 patients (mean age 77.5 ± 5.7, range 68-90 years) with a diagnosis of early AMD and 42 eyes of 42 age-matched control subjects (mean age 76.9 ± 5.7, range 67-88 years) were included. Of these, 28 eyes (58.3%) had drusen alone, 4 eyes (8.3%) had SDD alone, and 16 eyes (33.3%) had drusen associated with SDD. Compared with controls, average choroidal thickness was significantly decreased in AMD eyes (P < 0.05). There was no significant difference in choroidal thickness in eyes with SDD with respect to those with drusen alone. GCL-IPL thickness was reduced in an annular pattern at the 3 and 6 mm macular areas in AMD patients with respect to controls (P < 0.05). GCL-IPL thickness at 3 mm was significantly reduced in eyes with SDD with respect to those with drusen alone (P = 0.03). Conclusions The GCL-IPL is reduced in thickness with an annular pattern in early AMD and is significantly thinner in eyes with SDD.

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Thickness of the Macula, Retinal Nerve Fiber Layer, and Ganglion Cell–inner Plexiform Layer in the Age-Related Macular Degeneration

Cited by 18 publications

References 35 publications

Comparison of repeatability of swept-source and spectral-domain optical coherence tomography for measuring inner retinal thickness in retinal disease

Comparison of repeatability of swept-source and spectral-domain optical coherence tomography for measuring inner retinal thickness in retinal disease

Repeatability of measuring the vessel density in patients with retinal vein occlusion: An optical coherence tomography angiography study

Optical coherence tomography evidence of macular ganglion cell-inner plexiform layer thinning in eyes with subretinal drusenoid deposits

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