Thiamine deficiency in dogs due to the feeding of sulphite preserved meat

Singh, Manish Kumar; Thompson, Murray R.; Sullivan, Nancy J.; Child, Georgina

doi:10.1111/j.1751-0813.2005.tb13078.x

Cited by 48 publications

(53 citation statements)

References 9 publications

(23 reference statements)

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“…Thiamine-dependent biochemical processes includes the citric acid cycle and pentose phosphate pathway, which are major energy production process in the central nervous system (CNS) [2,9]. Since thiamine deficiency results in disturbances of energy metabolism, alternative anaerobic energy metabolism processes promote the accumulation of lactic acid in the CNS and lead to neuronal loss [2].…”

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confidence: 99%

Clinical signs, MRI features, and outcomes of two cats with thiamine deficiency secondary to diet change

2013

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Two cats were presented with vestibular signs and seizures. Both cats were diagnosed with thiamine deficiency. The transverse and dorsal T2-weighted magnetic resonance (MR) images revealed the presence of bilateral hyperintense lesions at specific nuclei of the midbrain, cerebellum, and brainstem. After thiamine supplementation, the clinical signs gradually improved. Repeated MR images taken 3 weeks after thiamine supplementation had started showed that the lesions were nearly resolved. This case report describes the clinical and MR findings associated with thiamine deficiency in two cats.

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Clinical signs, MRI features, and outcomes of two cats with thiamine deficiency secondary to diet change

2013

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“… ) or cerebrocortical necrosis secondary to metabolic or nutritional abnormalities ( Singh et al . , Dewey & da Costa ). However, the signalment of dogs in the current study, normal biochemical test results, CSF analysis demonstrating an eosinophilic pleocytosis and the specific nature of the MRI findings were not felt to be consistent with alternate differential diagnoses.…”

Section: Discussionmentioning

confidence: 97%

Clinical presentation and magnetic resonance imaging findings in 11 dogs with eosinophilic meningoencephalitis of unknown aetiology

Cardy

Cornelis

2018

J of Small Animal Practice

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Objectives To describe the clinical presentation, MRI findings and outcome in dogs with eosinophilic meningoencephalitis of unknown origin. Materials and Methods Dogs were included in this retrospective study if they had complete medical records, complete neurological examination, MR imaging, cerebellomedullary cerebrospinal fluid sample consistent with eosinophilic pleocytosis and negative infectious disease testing. Results Eleven dogs were included with a median age of 22·0 months (range 7·6 to 92·0 months). Nine breeds were represented. Neurological abnormalities included obtundation (n=10), menace response deficits (n=9), proprioceptive deficits (n=7), ataxia (n=7) and seizures (n=2). Neuroanatomical localisation was multi‐focal (n=4), central vestibular system (n=4), diffuse forebrain (n=2) or left trigeminal/facial nerves (n=1). Seven dogs had peripheral eosinophilia. Ten dogs had bilateral symmetrical lesions affecting the cortical grey matter, which was hyperintense on T2‐weighted and fluid‐attenuating inversion recovery images and iso‐ to hypointense on T1‐weighted images with associated meningeal contrast enhancement. MRI findings were consistent with diffuse meningitis and atrophy or necrosis of cortical grey matter. One dog had increased contrast uptake in the left trigeminal nerve. Ten dogs receiving corticosteroids survived to discharge, with seven also receiving cytarabine arabinoside. Median survival time was 762 days. Clinical Significance Eosinophilic meningoencephalitis of unknown origin affects younger larger‐breed dogs, with the majority having suspected diffuse cerebrocortical meningitis and cortical (polio)encephalitis, which can be identified on MRI. Response to immunosuppressive treatment is good in the medium to long term, although further studies are required in this area.

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“…To the authors' knowledge none of the toxic-metabolic and degenerative diseases described in dogs show an imaging pattern of diffuse bilateral and symmetric T2 and FLAIR hyperintensities in the white matter. On the contrary, bilateral but selective focal involvement of different brain areas has been observed in thiamine deficiency [31,32], hepatic encephalopathy [28,33], osmotic myelinolysis [28], and L2-hydroxyglutaric aciduria (L2-HGA) [34]. A degenerative disease showing MRI patter comparable to that observed in this case is the adult cheetah leukoencephalopathy [35].…”

Section: Discussionmentioning

confidence: 99%

Bilateral Telencephalic Gliomatosis Cerebri in a Dog

Ricciardi¹,

Simone²,

Giannuzzi³

et al. 2014

Case Reports in Veterinary Medicine

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An 8-year-old intact male Lagotto Romagnolo was presented with forebrain signs. Neuroanatomic localization was diffuse prosencephalon. MRI revealed diffuse, bilateral, and symmetric T2 and FLAIR hyperintensities in the parieto-occipital white matter and corpus callosum. No mass effect or contrast enhancement was noted. Analysis of cerebrospinal fluid revealed normal protein content and mild mononuclear pleocytosis. Atypical cells were not identified. 15 days later because of the worsening of clinical condition the patient was euthanized upon owner's request. Neuropathological investigations were consistent with gliomatosis cerebri (GC). Such an unusual imaging pattern appeared similar to some cases of human GC and to a previous reported case in a dog, suggesting a possible repeatable imaging findings for this rare brain neoplasm. GC should be included in the MRI differentials for diffuse bilateral white matter signal changes and specific MRI findings described in this report may help in reaching a presumptive diagnosis of this tumor. Case PresentationAn 8-year-old intact male Lagotto Romagnolo was evaluated for a 1-month history of abnormal mental status. Clinical and neurological examination findings included depression, decreased postural reactions in all four limbs, especially on the right side, and decreased menace response in both eyes. During clinical examination the dog had seizures. The medical case was considered to be consistent with a diffuse forebrain lesion. Because of the age of the patient and the absence of hyperthermia neoplasm was considered the most probable cause of neurological signs while inflammation was considered to be less likely. Complete blood count, serum chemistry, and urinalysis results were within normal limits.MRI of the brain was performed under general anesthesia using a 0.25 Tesla permanent magnet (ESAOTE VET-MR GRANDE, Esaote, Genoa, Italy). MRI sequences protocol included Fast Spin Echo T2-weighted images acquired in sagittal and transverse plane, a FLAIR acquired in the transverse plane, and Spin Echo T1-weighted images acquired in the transverse plane before and after intravenous administration of paramagnetic contrast medium (Magnegita-gadopentatedimeglumine 500 mmol/mL-insight agents; 0.15 mmol/kg BW). MRI showed extensive, bilateral, and symmetric T2 and FLAIR hyperintensity of the parietooccipital periventricular and subcortical white matter. The occipital lobes appeared severely involved. The lesions were isointense on T1-weighted images and did not enhance after contrast medium administration (Figures 1 and 2). On sagittal T2-weighted images the aboral part of the corpus callosum lacked homogeneous signal intensity and had illdefined margins (Figure 3). Mass effect or loss of anatomical architecture was not present. Based on the imaging findings toxic-metabolic or degenerative disorders involving white matter (leukoencephalopathy) were considered the main differential diagnoses, while an inflammatory process, either immunomediated or infectious, and a diffuse infiltr...

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Thiamine deficiency in dogs due to the feeding of sulphite preserved meat

Cited by 48 publications

References 9 publications

Clinical signs, MRI features, and outcomes of two cats with thiamine deficiency secondary to diet change

Clinical signs, MRI features, and outcomes of two cats with thiamine deficiency secondary to diet change

Clinical presentation and magnetic resonance imaging findings in 11 dogs with eosinophilic meningoencephalitis of unknown aetiology

Bilateral Telencephalic Gliomatosis Cerebri in a Dog

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