Thiamine, Cobalamin, Locally Injected Alone or Combination for Herpetic Itching

Lv, Zhongwei; Xú, Gang; Tang, Wei‐Zhen

doi:10.1097/ajp.0b013e3182a0e085

Cited by 13 publications

(7 citation statements)

References 56 publications

(65 reference statements)

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“…After 28 days, the pain in the combination group and those receiving only subcutaneous B12 reduced to a statistically significant degree. No serious adverse events were witnessed in all control groups [35].…”

Section: Post-herpetic Neuralgiamentioning

confidence: 84%

B12 as a Treatment for Peripheral Neuropathic Pain: A Systematic Review

et al. 2020

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Neuropathic pain describes a range of unpleasant sensations caused by a lesion or disease of the somatosensory nervous system. The sensations caused by neuropathic pain are debilitating and improved treatment regimens are sought in order to improve the quality of life of patients. One proposed treatment for neuropathic pain is vitamin B12, which is thought to alleviate pain by a number of mechanisms including promoting myelination, increasing nerve regeneration and decreasing ectopic nerve firing. In this paper, the evidence for B12 as a drug treatment for neuropathic pain is reviewed. Twenty four published articles were eligible for inclusion in this systematic review in which a range of treatment regimens were evaluated including both B12 monotherapy and B12 in combination with other vitamins or conventional treatments, such as gabapentinoids. Overall, this systematic review demonstrates that there is currently some evidence for the therapeutic effect of B12 in the treatment of post-herpetic neuralgia (level II evidence) and the treatment of painful peripheral neuropathy (level III evidence).

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Section: Post-herpetic Neuralgiamentioning

confidence: 84%

B12 as a Treatment for Peripheral Neuropathic Pain: A Systematic Review

et al. 2020

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“…Stracke et al 13 , using benfotiamine (600 or 300mg, orally, once a day during six weeks) for diabetic neuropathy, have observed significant analgesic results, especially when higher doses were used. Other three studies, now addressing postherpetic neuralgias, have shown that local subcutaneous cobalamin (1000µg once a day for 4 weeks) was superior to lidocaine to improve pain [14][15][16] . So, it is suggested that the association of vitamins B12, B6 and B1, respectively and especially, in the doses of 1500µg (orally and daily) or 2000µg (muscular twice a week), of 50mg and of 300mg (both orally and daily), are effective as analgesic drugs for neuropathic pain.…”

Section: Discussionmentioning

confidence: 99%

“…In addition, Bvits had anti-inflammatory and anti-itching action, the latter in post-herpetic neuralgia patients and have also improved functionality. When those vitamins were associated to conventional acute or chronic pain management, they have decreased time for analgesic and antiinflammatory drugs consumption, thus contributing to less deleterious adverse effects in some individuals 1,7,[10][11][12][13][14][15][16][17][18][19][20] . The review of publications on Bvits for neuropathic pain, a total of 6 studies, point to beneficial effects, but with different doses and administration routes.…”

Section: Discussionmentioning

confidence: 99%

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B complex vitamins for analgesic therapy

Gazoni¹,

Malezan²,

Santos³

2016

Revista Dor

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BACKGROUND AND OBJECTIVES:The B complex vitamins have been used as single therapy or combined to other drugs, such as anti-inflammatory drugs, in different clinical situations, such as degenerative spinal diseases, rheumatologic diseases, polyneuropathies and in different postoperative situations. This study aimed at identifying in the scientific literature most recent evidences of the use of B complex vitamins as analgesic therapy and at describing clinical situations where their analgesic action could be observed. CONTENTS: A search was carried out in Pubmed, Medline, LILACS, Cochrane Library and Scielo databases, contemplating the last 10 years and titles in Portuguese, Spanish and English. Keywords were: "pain", "B complex vitamins", "management", "vitamin B1", "vitamin B6", "vitamin B12", "thiamine", "pyridoxine" and "cyanocobalamin". Among 40 studies found, we have selected just musculoskeletal and neuropathic pain trials with humans, and where B complex vitamins were used as analgesic agents. From these, 13 studies were selected for meeting inclusion criteria. In all of them, B complex vitamins played roles in analgesia, even when in single therapy. B complex vitamins had also anti-inflammatory and anti-pruritus action, in addition to improving functionality. CONCLUSION: Existing studies, although scarce and heterogeneous, have shown that B complex vitamins have analgesic effect. They are considered safe and have low cost and have shown to be a good option as adjuvant analgesic therapy. Keywords: B complex vitamins, Management, Pain. B complex vitamins for analgesic therapy O uso de vitaminas do complexo B em terapêutica analgésica RESUMO JUSTIFICATIVA E OBJETIVOS:As vitaminas do complexo B têm sido utilizadas em monoterapia ou combinada a outros fár-macos, como os anti-inflamatórios, em diversas situações clinicas, como por exemplo, nas doenças degenerativas da coluna, doenças reumatológicas, polineuropatias e nos pós-operatórios diversos. O objetivo deste estudo foi identificar na literatura científica as evidências mais recentes do uso de vitaminas do complexo B como terapia analgésica e descrever as situações clínicas em que se pode verificar a sua ação analgésica. CONTEÚDO: Realizada a revisão bibliográfica na base de dados do Pubmed, Medline, LILACS, Biblioteca Cochrane e Scielo, contemplando os últimos 10 anos, títulos em português, espanhol e inglês. Os descritores utilizados foram: "Dor", "vitaminas do complexo B", "tratamento", "vitamina B1", "vitamina B6", "vitamina B12", "tiamina", "piridoxina" e "cianocobalamina". Dentre os 40 estudos encontrados selecionaram-se apenas os trials em dor musculoesquelética e neuropática com seres humanos, e em que as vitaminas do complexo B configuraram-se como agentes analgésicos. Foram selecionados então 13 estudos que satisfizeram esses critérios de inclusão. Em todos eles as vitaminas do complexo B desempenharam papéis na analgesia, inclusive quando em monoterapia. As vitaminas do complexo B também apresentaram ação anti-inflamatória, anti-prurigi...

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“…При сравнении эффективности локальной инъекци-онной терапии в остром периоде герпетических высыпа-ний лечение проводят лидокаином и витаминами В 1 и В 12 , а также их комбинацией. Было показано, что локальное введение В 1 позволяло значительно уменьшать зуд, в то время как В 12 оказывал стойкий обезболивающий эффект, а их комбинация влияла на оба параметра достоверно эф-фективнее монотерапии лидокаином [37]. Однако нет до-казательств, что именно локальное введение витаминов группы В позволяет уменьшить зуд и болевой синдром, так как группы сравнения, получавшей витамины В 1 и В 12 системно, в этом исследовании не было.…”

Section: постоянная невропатическая больunclassified

Facial pain

Makhinov¹,

Баринов²,

Zhestikova³

et al. 2015

Z. nevrol. psikhiatr. im. S.S. Korsakova

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Распространенность орофациальных болей у взрос-лых составляет до 10%, мужчины страдают вдвое чаще женщин, что отличается от общих гендерных тенденций распространенности болевых синдромов, чаще встречаю-щихся у женщин. Эпидемиологический анализ особенно-стей лицевых болей (ЛБ) у 7124 респондентов показал, что у 7% отмечались боли в орофациальной области в течение последней недели, а при наблюдении на протяжении 12 мес этот показатель возрастал до 16%. Другим эпидемио-логическим парадоксом орофациальных болевых синдро-мов является снижение их распространенности с возрас-том, в то время как распространенность болевых синдро-мов другой локализации у пожилых нарастает [1,2].Орофациальные болевые синдромы сложно диагно-стируются ввиду многообразия анатомического строения отдельных образований и структур области лица и рта, морфологических и функциональных особенностей пе-риферического и центрального отделов нервной системы, обеспечивающих их афферентную и эфферентную иннер-вацию, влияния психологических факторов на клиниче-скую картину ЛБ. Чувствительная иннервация лица обе- Проблема диагностики и лечения лицевых болей требует участия врачей разных специальностей -неврологов, стоматологов, хирургов, окулистов, оториноларингологов и психиатров. Классификации этой нозологии все еще далеки от совершенства и требуют междисциплинарного подхода в разработке для полного понимания врачами разных специальностей. В статье изложены современные подходы к этиотропной, симптоматической и патогенетической терапии пациентов с наиболее распространенными видами орофациальных болей. Ключевые слова: орофациальная боль, классификация лицевых болей, дисфункция височно-нижнечелюстного сустава, синдром Толоса-Ханта, тригеминальная невралгия, глоссофарингеальная невралгия, синдром горящего рта, деафферентационная боль, персистирующая идиопатическая лицевая боль.Diagnosis and treatment of facial pain is a problem for physicians of different specialties (neurologists, dentists, surgeons, oculists, otolaryngologists and psychiatrists). A classification of this pathology is far from ideal and an interdisciplinary comprehensive approach is needed. Current approaches to etiotropic, symptomatic and pathogenetic treatment of patients with most frequent variants of orofacial pain are presented. спечивается преимущественно тройничным нервом, а в ротовой полости -также языкоглоточным, блуждающим и лицевым нервами. Особенностью иннервации кожи и слизистой оболочки лица является высокая плотность ре-цепторов, многие из которых могут быть активизированы различными по модальности раздражителями (болевые, температурные, химические или механические). Большей частью ноцицептивная информация передается Аδ-волокнами. Височно-нижнечелюстной сустав (ВНС) и жевательная мышца иннервированы Аδ-и С-волокнами. Роговица также иннервирована Аδ-и С-волокнами, воз-буждающимися механическими, температурными и хи-мическими стимулами при низких порогах активации ре-цепторов. Пульпа зуба снабжена Аδ-и С-, Аβ-и симпати-ческими волокнами. Поражение каждого нерва характе-ризуется...

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Thiamine, Cobalamin, Locally Injected Alone or Combination for Herpetic Itching

Abstract: Locally injected thiamine had a significant antipruritic effect, cobalamin had an analgesic effect, and their combination had the dual effect with no obvious synergies. This intervention was efficacious, tolerable, and safe for herpetic itching.

Cited by 13 publications

References 56 publications

B12 as a Treatment for Peripheral Neuropathic Pain: A Systematic Review

B12 as a Treatment for Peripheral Neuropathic Pain: A Systematic Review

B complex vitamins for analgesic therapy

Facial pain

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