Thiadiazolyl Quinazolones as Potential Antiviral and Antihypertensive Agents.

Abstract

Fused pyrimidine derivativesFused pyrimidine derivatives R 0515 Thiadiazolyl Quinazolones as Potential Antiviral and Antihypertensive Agents. -Compounds (IXa) and (IXb) show antiviral activity, while compound (IXc) shows antihypertensive activity. -(PANDEY*, V. K.; TUSI, S.; TUSI, Z.; RAGHUBIR, R.; DIXIT, M.; JOSHI, M. N.; BAJPAI, S. K.; Indian J.

Synthesis and Antibacterial Activity of Some Novel 4-Benzyl-piperazinyl-s-triazine Derivatives

“…Among them s-triazine scaffold is of immense importance. Substituted s-triazine derivatives have become attractive targets for medicinal chemistry due to its potent biological activity such as antiprotozoal 13 , anticancer [14][15][16] , estrogen receptor modulators 17 , antimalarial [18][19][20][21] , cyclin-dependent kinase inhibitors 22 , antiviral 23 , vascular inflammatory disease 24 , CNS depressant 25 , antitubercular 26 , 3a-f 5a-j 4a-j 6 Asian Journal of Chemistry; Vol. 25, No.…”

Synthesis, In Vitro Evaluation of Some Novel Quinazolin-4(3H)-one Derivatives as Anti-Tumor Agents

“…In search for new bioactive potent molecule, it was thought worth while to incorporate some additional heterocyclic moieties in the quinazoline nucleus and study their biological and pharmacological activity, the extensive review of literature revealed the compounds have anticancer activity [1][2][3][4] . The earliest uses in the pharmaceutical area for quinazoline are anti viral 5 , anti parkinsonism 6,7, anti microbial [8][9][10][11] , anti inflammatory 12 , bronchodilator 13 , anti hypertensive 14 . Encouraged by the above observations from the literature, it was planned to suitably incorporate the Mannich bases in to quinazolinone and to synthesize a better drug with less toxicity to the host, it is observed that chemical modification not only alters physiochemical properties but also pharmacological properties.…”

An Easy and Efficient Protocol for the Synthesis of 2,3-Dihydroquinazolinones Using a Low Cost and Reusable Heterogeneous Catalyst

“…I n a d d it io n 2, 3-d ih y d ro -2-p h en y lq u in azo lin -4( 1 H) -o n es are p o tent tubulin inhib itors with imp ressive antiprolivative activity against several human cancers with IC 50 value in nano molar concentration. It acts analogously to Colchicine (inhibitors of tubulin poly merization) by binding to α, β -tublin (4).The 2,3-disubstituted quinazolones have been predicted to possess antiviral and antihypertensive activities (5). Additionally, these compounds can easily be oxidized to their quinazolin-4(3H)-one analogs, wh ich is defined as a class of molecu les that are capable of binding to mu ltip le receptors with high affinity (6).…”