Synthesis and Antibacterial Activity of Some Novel 4-Benzyl-piperazinyl-s-triazine Derivatives

Abstract

Considerable interest has been attracted in s-triazine scaffold and its derivatives because of their large variety of pharmacological activities. In this project, a series of 4-benzyl-piperazinyl-s-triazine derivatives 5a to 5j were synthesized by three steps substitution reaction of cyanuric chloride with various nucleophilic compounds in presence of a base. Molecular structures of the synthesized compounds were elucidated by FTIR,

Facile Synthesis, Characterization, and In Vitro Antimicrobial Screening of a New Series of 2,4,6-Trisubstituted-s-triazine Based Compounds

“…Recently, 4-benzyl piperazine derivatives of s -triazine were also found to be active against some Gram positive and Gram negative bacterial strains [16]. The importance of piperazine moiety has been substantiated by the fact that several N -alkyl and N -aryl piperazine derivatives showed potent antibacterial activity against resistant microbial strains [17, 18].…”