Theta burst TMS increases cerebral blood flow in the primary motor cortex during motor performance as assessed by arterial spin labeling (ASL)

Orosz, Ariane; Jann, Kay; Wirth, Miranka; Wiest, Roland; Dierks, Thomas; Federspiel, Andrea

doi:10.1016/j.neuroimage.2012.03.084

Cited by 30 publications

(20 citation statements)

References 68 publications

(84 reference statements)

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“…By combining TMS and ASL in a basic clinical study, we have previously shown that TMS to the primary motor cortex caused a significant increase in CBF compared to sham, suggesting that inhibitory TMS induced a ''virtual lesion'' which then led to the mobilization of additional neuronal resources. As we did not find a specific modulation in motor behavior, we concluded that acute changes caused in the brain by TMS are probably compensated immediately and that this compensation is observable on a metabolic but not on a motoric level [19].…”

Section: S92contrasting

confidence: 57%

Auditory verbal hallucinations: imaging, analysis, and intervention

Homan

Kindler

Hubl

et al. 2012

Eur Arch Psychiatry Clin Neurosci

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In this article, we will link neuroimaging, data analysis, and intervention methods in an important psychiatric condition: auditory verbal hallucinations (AVH). The clinical and phenomenological background as well as neurophysiological findings will be covered and discussed with respect to noninvasive brain stimulation. Additionally, methods of noninvasive brain stimulation will be presented as ways to intervene with AVH. Finally, preliminary conclusions and possible future perspectives will be proposed.

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Section: S92contrasting

confidence: 57%

Auditory verbal hallucinations: imaging, analysis, and intervention

Homan

Kindler

Hubl

et al. 2012

Eur Arch Psychiatry Clin Neurosci

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“…This finding can be explained when considering the seeds used for either dataset. The seeds were chosen based on a random effects GLM using the fingertapping task-predictor as the regressor (Orosz et al 2012). The significant differences were exactly in the spots where the two seeds differed.…”

Section: Discussionmentioning

confidence: 99%

“…The study was approved by the ethical committee of Bern, Switzerland and was in agreement with the latest Declaration of Helsinki. The same subject group was previously analyzed and published in the study of Orosz et al (2012).…”

Section: Subjectsmentioning

confidence: 99%

“…The two recording sessions of each subject were randomly assigned to two different datasets (Data1/Data2) (Orosz et al 2012). …”

Section: Task Designmentioning

confidence: 99%

“…Seed regions were chosen based on the activation clusters published in (Orosz et al 2012) determined by standard random effects GLM analyses to these datasets. For Data1 the center of gravity ± SD (Talairch x/y/z) and volume of the seed was 28.0 ± 4.2/-26.9 ± 2.5/45.7 ± 3.9/1,177 mm 3 and for Data2 it was 29.6 ± 2.9/-29.4 ± 2.6/ 43.9 ± 3.3/819 mm 3 .…”

Section: Seed Based Functional Connectivity Analysis (Sba)mentioning

confidence: 99%

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Quantification of Network Perfusion in ASL Cerebral Blood Flow Data with Seed Based and ICA Approaches

et al. 2013

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Independent component analysis (ICA) or seed based approaches (SBA) in functional magnetic resonance imaging blood oxygenation level dependent (BOLD) data became widely applied tools to identify functionally connected, large scale brain networks. Differences between task conditions as well as specific alterations of the networks in patients as compared to healthy controls were reported. However, BOLD lacks the possibility of quantifying absolute network metabolic activity, which is of particular interest in the case of pathological alterations. In contrast, arterial spin labeling (ASL) techniques allow quantifying absolute cerebral blood flow (CBF) in rest and in task-related conditions. In this study, we explored the ability of identifying networks in ASL data using ICA and to quantify network activity in terms of absolute CBF values. Moreover, we compared the results to SBA and performed a test-retest analysis. Twelve healthy young subjects performed a fingertapping block-design experiment. During the task pseudo-continuous ASL was measured. After CBF quantification the individual datasets were concatenated and subjected to the ICA algorithm. ICA proved capable to identify the somato-motor and the default mode network. Moreover, absolute network CBF within the separate networks during either condition could be quantified. We could demonstrate that using ICA and SBA functional connectivity analysis is feasible and robust in ASL-CBF data. CBF functional connectivity is a novel approach that opens a new strategy to evaluate differences of network activity in terms of absolute network CBF and thus allows quantifying inter-individual differences in the resting state and task-related activations and deactivations.

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Bidirectional effects on interhemispheric resting‐state functional connectivity induced by excitatory and inhibitory repetitive transcranial magnetic stimulation

Watanabe

Hanajima

Shirota

et al. 2013

Human Brain Mapping

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Several recent studies using functional magnetic resonance imaging (fMRI) have shown that repetitive transcranial magnetic stimulation (rTMS) affects not only brain activity in stimulated regions but also resting-state functional connectivity (RSFC) between the stimulated region and other remote regions. However, these studies have only demonstrated an effect of either excitatory or inhibitory rTMS on RSFC, and have not clearly shown the bidirectional effects of both types of rTMS. Here, we addressed this issue by performing excitatory and inhibitory quadripulse TMS (QPS), which is considered to exert relatively large and long-lasting effects on cortical excitability. We found that excitatory rTMS (QPS with interstimulus intervals of 5 ms) decreased interhemispheric RSFC between bilateral primary motor cortices, whereas inhibitory rTMS (QPS with interstimulus intervals of 50 ms) increased interhemispheric RSFC. The magnitude of these effects on RSFC was significantly correlated with that of rTMS-induced effects on motor evoked potential from the corresponding muscle. The bidirectional effects of QPS were also observed in the stimulation over prefrontal and parietal association areas. These findings provide evidence for the robust bidirectional effects of excitatory and inhibitory rTMSs on RSFC, and raise a possibility that QPS can be a powerful tool to modulate RSFC.

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Theta burst TMS increases cerebral blood flow in the primary motor cortex during motor performance as assessed by arterial spin labeling (ASL)

Cited by 30 publications

References 68 publications

Auditory verbal hallucinations: imaging, analysis, and intervention

Auditory verbal hallucinations: imaging, analysis, and intervention

Quantification of Network Perfusion in ASL Cerebral Blood Flow Data with Seed Based and ICA Approaches

Bidirectional effects on interhemispheric resting‐state functional connectivity induced by excitatory and inhibitory repetitive transcranial magnetic stimulation

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