"These Dying Diseases "

Present pattern of antibiotic sensitivity of gonococcal strains isolated in Bombay.

“…Thus the 'two-peak' phenomenon in the distribution of sensitivity to penicillin reported be several workers (Cradock-Watson and others, 1958;Curtis and Wilkinson, 1958;King, 1958;Reyn and others, 1958;Chacko and Yogeswari, 1966) has been interpreted as a step-wise change in sensitivity, supporting the hypothesis that penicillin resistance 1958 1945 1955 1947 1955 1955 1954 1951 1957 1958 1958 1958 1966 1969 1966 1969 1944 1945 1945 1947 1947 1949 1950-52 1951 1955-56 1957 1957 1957 1958 1961 1963-65 1967-68 1968-69 Percentage with Total number decreased tested sensitivity develops in a series of multiple steps. In the present study, both spiramycin and erythromycin also showed the 'two-peak' phenomenon, while tetracycline and chloramphenicol showed single peaks.…”

Treatment Problems of Gonorrhoea

“…(Taiwan),1 Hong Kong,2 Japan,' Korea,' Laos,' Philippines,3 and the United Kingdom (King, 1958;Knight, 1958;Willcox, 1958). Cases of gonorrhoea have been recorded which have not responded to penicillin (Stuhlert, 1957).…”

“…Meanwhile an increasing number of failures to repository penicillin had become apparent in some parts of the world, notably in London (Willcox, 1958), when it was observed that previously successful doses of penicillin were now being more frequently associated with persistence or relapse of infection (King, 1958 Table 3). Similarly, in the USA, it has been reported that from 1944-54 386 strains of gonococci ranged in susceptibility to penicillin from 0.002-0.333 units/ml.…”

“…On the other hand it is likely that its widespread use would result in a preponderance of relatively resistant strains of gonococci to this antibiotic also (King, 1958).…”

Open access for screening is vital

“…History has shown that gonorrhoea is difficult to eradicate but can be controlled at a low level. New remedies may inspire false confidence and attitudes towards this and other sexually transmitted diseases 2. While effective gonococcal treatment is available, control must depend more on diagnostic methods, notification of partners, health education, and widespread screening, especially in areas of high prevalence.…”