Present pattern of antibiotic sensitivity of gonococcal strains isolated in Bombay.

Moses, John M.; Desai, Mamta; Bhosle, C. B.; Trasi, M S

doi:10.1136/sti.47.4.273

Cited by 11 publications

(9 citation statements)

References 10 publications

(10 reference statements)

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“…The percentage of our strains demonstrating an increased resistance to penicillin would seem to be higher than that found in Europe (Lynn, Nicol, Ridley, Rimmer, Symonds, and Warren, 1970;Nielsen, 1970), but lower than that seen in Asia and western North America (Holmes, Johnson, and Floyd, 1967;Ronald, Eby, and Sherris, 1970;Reyn, 1969;Willcox, 1970;Moses, Desai, Bhosle, and Trasi, 1971). The results are similar to those reported from the Center for Disease Control in the United States (Martin, Lester, Price, and Schmale, 1970).…”

Section: Discussionsupporting

confidence: 77%

Penicillin sensitivity of gonococci in Ethiopia.

Plorde¹,

Kidan²,

Wright³

1973

Sexually Transmitted Infections

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Section: Discussionsupporting

confidence: 77%

Penicillin sensitivity of gonococci in Ethiopia.

Plorde¹,

Kidan²,

Wright³

1973

Sexually Transmitted Infections

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“…This is comparable with the East African figures and with 85 % reported in the Far East (Keys et al, 1969), but is higher than the British figures of 17-6% (Shannon et al, 1975) and30% (Shahidulla andGreaves, 1975). It is also higher than the figures reported from Bombay (Moses et al, 1971) and the 7000 reported from the USA (Jaffe et al, 1976). The level of gonococcal penicillin resistance in our series therefore ranks as one of the highest in the world.…”

Section: Resultssupporting

confidence: 71%

Sensitivity pattern of Neisseria gonorrhoeae to penicillin and screening for -lactamase production in Ibadan, Nigeria

Osoba

Montefiore

Sogbetun

et al. 1977

Sexually Transmitted Infections

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SUMMARY The few reports from Africa on sensitivity determinations of Neisseria gonorrhoeae suggest that there is an increasing resistance in the strains, as has been found in other parts of the world. In the current study, the penicillin sensitivities and p-lactamase production of 80 consecutive strains of N. gonorrhoeae isolated from cases of acute urethritis in African men in Ibadan were studied. Of these strains, 17-5 % had a penicillin minimum inhibitory concentration (MIC) of 0-038 ,ug/ml or less and were considered as being 'fully sensitive'. However, 82-5 % had an MIC of 0 075 jig penicillin/ml or more, and were considered as having 'diminished sensitivity' to penicillin.It was thought that this high incidence of relatively insensitive strains was owing to the sequential selection of these strains because of the easy availability and abuse of antimicrobial agents by the general population. Furthermore, 13 strains (16.25%) demonstrated high level resistance with MIC values of over 0-6 tig penicillin per ml and it is probable that many of the strains will demonstrate multiresistance to the commonly misused antimicrobial agents. Consequently, treatment of patients harbouring these strains may present problems because of financial constraints of the health services in purchasing the appropriate antibiotics. Despite the high level resistance of the strains in an environment of intensive penicillin and ampicillin use, none of the strains studied showed any evidence of p-lactamase production. Nevertheless, continuous surveillance of r-lactamase production by the gonococcus is recommended in the larger medical centres in developing countries.

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“…The MIC values of isolates from patients who fail to respond to treatment are of interest; however, Duncan Date 194719551961196719641967196819671967197119691975 MIC values originally reported in units/ml. have been converted to ,ug./ml.…”

Section: Resultsmentioning

confidence: 99%