Thermotropic gelation induced changes in micropolarity and microviscosity of hydrogel derived from glucose-triazole-hydrogenated cardanol conjugate: a study using fluorescent molecular probe

Swain, Jitendriya; Kamalraj, M.; Rao, H. Surya Prakash; Mishra, Ashok Kumar

doi:10.1039/c4ra08686d

Cited by 10 publications

(8 citation statements)

References 28 publications

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“…2b and S3 †) using the hydrophobic uorescent molecular probe 8-anilino-1-naphthalenesulfonic acid (ANS), widely used to sense micropolarity variation following the formation of supramolecular nanostructures, demonstrated that upon incubation at 40 C the spontaneous assembly proceeds rapidly and reaches a stable level within a convenient operative time frame (1-4 hours). 50,51 This behaviour was also observed using thioavin ( Fig. S4 †).…”

Section: Hydrogel Design and Characterizationsupporting

confidence: 73%

A self-assembling peptide hydrogel for ultrarapid 3D bioassays

et al. 2019

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Section: Hydrogel Design and Characterizationsupporting

confidence: 73%

A self-assembling peptide hydrogel for ultrarapid 3D bioassays

et al. 2019

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“…Microfluidity obtained from fluorescence anisotropy value and microviscosity calculated by using fluorescence anisotropy and fluorescence lifetime value (using eq ) gives information about the rigidity of the surrounding environments of the probe in an organized media Figure shows the variation in fluorescence anisotropy and microviscosity values of fisetin in PF127 (10% w/v) medium with temperature.…”

Section: Resultsmentioning

confidence: 99%

“…The microviscosity of the medium can be calculated by using the Perrin equation, eq , which includes fluorescence anisotropy and fluorescence lifetime data Here r o = Limiting anisotropy value of the probe in the absence of any depolarizing process.…”

Section: Methodsmentioning

confidence: 99%

Molecular Level Understanding of Sodium Dodecyl Sulfate (SDS) Induced Sol–Gel Transition of Pluronic F127 Using Fisetin as a Fluorescent Molecular Probe

Mishra

Swain

2017

J. Phys. Chem. B

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The thermoreversible sol-gel transition of pluronic F127 is markedly altered even with addition of submicellar concentration of sodium dodecyl sulfate (SDS) surfactant. Multiple fluorescence parameters like fluorescence intensity, fluorescence anisotropy and fluorescence lifetime of both the prototropic forms (anion (A*) and phototautomer FT*) of the photoprototropic fluorescent probe fisetin has been efficiently used to understand the molecular level properties like polarity and microviscosity of the PF127-SDS system as a function of temperature. The SDS-induced increase in the interfacial hydrophobicity level is seen to affect the sol-gel phase transition of PF127 (21-18 °C). The E(30) polarity parameter value of anionic emission of fisetin suggests that there is a considerable decrease in the polarity of the PF127 medium with increase in temperature and with the addition of SDS. The microviscosity progressively increases from ∼5 mPa s (sol state, 10 °C) to ∼22.01 mPa s (gel state 35 °C) in aqueous solution of PF127. The variation in microviscosity with addition of SDS in PF127-SDS mixed system is significant in sol phase whereas in gel phase this variation is significantly less. Temperature dependent fluorescence lifetime of FT* indicates that there is heterogeneity in distribution of fisetin molecules at different domains of PF127. This work also show-cases the sensitivity of fisetin toward change in polarity and change in sol-gel transition temperature of copolymer PF127 with variation in temperature (both forward and reverse directions) and SDS.

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“…Acting as a class of chemosensor, hydrogels help monitor the signal changes associated with molecular recognition. 1025 , 1026 As a pioneer in the applications of hydrogels for chemosensing, Hamachi et al developed a supramolecular hydrogel formed by 499 molecules ( Scheme 63 ) as a platform for a semiwet sensor chip. 845 They created a hydrogel-based array on a glass plate by incorporating artificial receptors into the heated solution of the hydrogelator 499 and spotting them on a glass plate.…”

Section: Applicationsmentioning

confidence: 99%

Supramolecular Hydrogelators and Hydrogels: From Soft Matter to Molecular Biomaterials

et al. 2015

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In this review we intend to provide a relatively comprehensive summary of the work of supramolecular hydrogelators after 2004 and to put emphasis particularly on the applications of supramolecular hydrogels/hydrogelators as molecular biomaterials. After a brief introduction of methods for generating supramolecular hydrogels, we discuss supramolecular hydrogelators on the basis of their categories, such as small organic molecules, coordination complexes, peptides, nucleobases, and saccharides. Following molecular design, we focus on various potential applications of supramolecular hydrogels as molecular biomaterials, classified by their applications in cell cultures, tissue engineering, cell behavior, imaging, and unique applications of hydrogelators. Particularly, we discuss the applications of supramolecular hydrogelators after they form supramolecular assemblies but prior to reaching the critical gelation concentration because this subject is less explored but may hold equally great promise for helping address fundamental questions about the mechanisms or the consequences of the self-assembly of molecules, including low molecular weight ones. Finally, we provide a perspective on supramolecular hydrogelators. We hope that this review will serve as an updated introduction and reference for researchers who are interested in exploring supramolecular hydrogelators as molecular biomaterials for addressing the societal needs at various frontiers.

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Thermotropic gelation induced changes in micropolarity and microviscosity of hydrogel derived from glucose-triazole-hydrogenated cardanol conjugate: a study using fluorescent molecular probe

Abstract: Glucose-triazole-hydrogenated cardanol conjugates (GTHCC): A thermoreversible supergelator.

Cited by 10 publications

References 28 publications

A self-assembling peptide hydrogel for ultrarapid 3D bioassays

A self-assembling peptide hydrogel for ultrarapid 3D bioassays

Molecular Level Understanding of Sodium Dodecyl Sulfate (SDS) Induced Sol–Gel Transition of Pluronic F127 Using Fisetin as a Fluorescent Molecular Probe

Supramolecular Hydrogelators and Hydrogels: From Soft Matter to Molecular Biomaterials

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