Thermotherapy of Prostate Cancer Using Magnetic Nanoparticles: Feasibility, Imaging, and Three-Dimensional Temperature Distribution

Johannsen, Manfred; Gneveckow, Uwe; Thiesen, Burghard; Taymoorian, Kasra; Cho, Chie Hee; Waldöfner, Norbert; Scholz, Robert; Jordan, Andreas; Loening, Stefan A.; Wust, Peter

doi:10.1016/j.eururo.2006.11.023

Cited by 458 publications

(329 citation statements)

References 28 publications

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“…This was confirmed by experimental data showing that about 90% of the injected amount of iron was detectable by CT in tissue samples [39]. We speculate that the remaining 10% represent areas of low iron concentration, presumably in the periphery of larger deposits or needle tracks.…”

Section: Discussionsupporting

confidence: 73%

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Clinical applications of magnetic nanoparticles for hyperthermia

Thiesen¹,

Jordan

2008

International Journal of Hyperthermia

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719

556

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Magnetic fluids are increasingly used for clinical applications such as drug delivery, magnetic resonance imaging and magnetic fluid hyperthermia. The latter technique that has been developed as a cancer treatment for several decades comprises the injection of magnetic nanoparticles into tumors and their subsequent heating in an alternating magnetic field. Depending on the applied temperature and the duration of heating this treatment either results in direct tumor cell killing or makes the cells more susceptible to concomitant radio-or chemotherapy. Numerous groups are working in this field worldwide, but only one approach has been tested in clinical trials so far. Here, we summarize the clinical data gained in these studies on magnetic fluid induced hyperthermia.

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Section: Discussionsupporting

confidence: 73%

“…Median urethral and rectal temperatures were 40.5 C (range 38.4-43.6) and 39.8 C (range 38.2-43.4). The median thermal dose was 7.8 (range 3.5-136.4) cumulative equivalent minutes at 43 C in 90% of the prostates [39].…”

Section: Magnetic Fluid Hyperthermia In Recurrent Prostate Carcinomamentioning

confidence: 99%

Clinical applications of magnetic nanoparticles for hyperthermia

Thiesen¹,

Jordan

2008

International Journal of Hyperthermia

Self Cite

719

556

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“…has developed into an area of widespread activity in recent years in response to a broad range of potential applications, such as remediation of contaminated land and water [1][2][3], catalysis [4,5], targeted drug delivery [6], magnetic data storage [7] and magnetic thermotherapy targeting cancerous tumours [8][9][10].…”

Section: Introductionmentioning

confidence: 99%

Controlled cobalt doping in biogenic magnetite nanoparticles

Byrne

Coker

Moise

et al. 2013

J. R. Soc. Interface.

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Cobalt-doped magnetite (Co x Fe 32x O 4 ) nanoparticles have been produced through the microbial reduction of cobalt-iron oxyhydroxide by the bacterium Geobacter sulfurreducens. The materials produced, as measured by superconducting quantum interference device magnetometry, X-ray magnetic circular dichroism, Mössbauer spectroscopy, etc., show dramatic increases in coercivity with increasing cobalt content without a major decrease in overall saturation magnetization. Structural and magnetization analyses reveal a reduction in particle size to less than 4 nm at the highest Co content, combined with an increase in the effective anisotropy of the magnetic nanoparticles. The potential use of these biogenic nanoparticles in aqueous suspensions for magnetic hyperthermia applications is demonstrated. Further analysis of the distribution of cations within the ferrite spinel indicates that the cobalt is predominantly incorporated in octahedral coordination, achieved by the substitution of Fe 2þ site with Co 2þ , with up to 17 per cent Co substituted into tetrahedral sites.

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“…The heat generation ability (W·g 1 ) of these ferrite materials in an AC magnetic field knowing the arbitrary frequency f (kHz) and the magnetic field H (kA·m 1 ) can be easily estimated using Eq. (2). Figure 9 plots the heat generation ability and the hysteresis loss for the samples of the Y 3 Fe 5 O 12 -nSiC (n = 0, 0.3, and 1.0) system calcined at various temperatures.…”

Section: Characterization Of Sample Powdermentioning

confidence: 99%

“…The heat generation ability in an AC magnetic field for magnetic materials has been studied for the local treatment of cancerous tissues [1][2][3][4][5][6][7]. Materials of the needle type and powder type have been studied for this purpose.…”

Section: Introductionmentioning

confidence: 99%

Heat generation properties in AC magnetic field for composite powder material of the Y3Fe5O12–nSiC system prepared by reverse coprecipitation method

et al. 2016

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Abstract:Composite powder material of the Y 3 Fe 5 O 12 -nSiC system was synthesized by a reverse coprecipitation method to study its heat generation property in an AC magnetic field. For Y 3 Fe 5 O 12 (n = 0), the maximum heat generation ability of 0.45 W·g 1 in an AC magnetic field (370 kHz, 1.77 kA·m 1 ) was obtained for the sample calcined at 1100 .℃ The SiC addition helped to suppress the particle growth for Y 3 Fe 5 O 12 at the calcination temperature. The heat generation ability was improved by the addition of the SiC powder, and the maximum value of 0.93 W·g 1 was obtained for the n = 0.3 sample calcined at 1250 . The ℃ heat generation ability and the hysteresis loss value were proportional to the cube of the magnetic field (H 3 ). The heat generation ability (W·g 1 ) of the Y 3 Fe 5 O 12 -0.3SiC sample calcined at 1250 ℃ could be expressed by the equation 4.5×10 4 · f · H 3 using the frequency f (kHz) and the magnetic field H (kA·m 1 ).

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Thermotherapy of Prostate Cancer Using Magnetic Nanoparticles: Feasibility, Imaging, and Three-Dimensional Temperature Distribution

Cited by 458 publications

References 28 publications

Clinical applications of magnetic nanoparticles for hyperthermia

Clinical applications of magnetic nanoparticles for hyperthermia

Controlled cobalt doping in biogenic magnetite nanoparticles

Heat generation properties in AC magnetic field for composite powder material of the Y3Fe5O12–nSiC system prepared by reverse coprecipitation method

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