Thermosensitive Liposomes Modified with Poly(<i>N</i>-isopropylacrylamide-<i>co</i>-propylacrylic acid) Copolymers for Triggered Release of Doxorubicin

Ta, Terence; Convertine, Anthony J.; Reyes, Clementina; Stayton, Patrick S.; Porter, Tyrone M.

doi:10.1021/bm1004993

Cited by 117 publications

(92 citation statements)

References 30 publications

(77 reference statements)

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“…It is well known that poly(diisopropylacrylamide) is a good thermal-sensitive polymer, and liposomes containing poly(diisopropylacrylamide) have shown temperaturedependent release of contents. 44 PEAA has a chemical structure similar to that of poly(acrylic acid), with extra ethyl groups at the 2-position. Therefore, by carefully controlling the amount of diisopropylamide in the modified PEAA, the new PEAA liposomes would still be pH-sensitive and also thermal-sensitive.…”

Section: Discussionmentioning

confidence: 99%

Influence of polymer size, liposomal composition, surface charge, and temperature on the permeability of pH-sensitive liposomes containing lipid-anchored poly(2-ethylacrylic acid)

Lu¹,

Wang²,

Ma³

et al. 2012

IJN

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Background: Liposomes containing pH-sensitive polymers are promising candidates for the treatment of tumors and localized infection. This study aimed to identify parameters influencing the extent of contents release from poly(ethylacrylic acid) (PEAA) vesicles, focusing on the effects of polymer size, lipid composition, vesicle surface charge, and temperature. Methods: Anchored lipid pH-sensitive PEAA was synthesized using PEAA with a molecular weight of 8.4 kDa. PEAA vesicles were prepared by insertion of the lipid-anchored PEAA into preformed large unilamellar vesicles. The preformed liposomes were manipulated by varying the phosphocholine and cholesterol content, and by adding negative or positive charges to the liposomes. A calcein release assay was used to evaluate the effects of polymer size, liposome composition, surface charge, and temperature on liposomal permeability. Results: The release efficiency of the calcein-entrapped vesicles was found to be dependent on the PEAA polymer size. PEAA vesicles containing a phosphatidylcholine to cholesterol ratio of 60:40 (mol/mol) released more than 80% of their calcein content when the molecular weight of PEAA was larger than 8.4 kDa. Therefore, the same-sized polymer of 8.4 kDa was used for the rest of study. The calcein release potential was found to decrease as the percentage of cholesterol increased and with an increase in the phosphocholine acyl chain length (DMPC . DPPC . DSPC). Negatively charged and neutral vesicles released similar amounts of calcein, whereas positively charged liposomes released a significant amount of their contents. pH-sensitive release was dependent on temperature. Dramatic content release was observed at higher temperatures. Conclusion:The observed synergistic effect of pH and temperature on release of the contents of PEAA vesicles suggests that this pH-sensitive liposome might be a good candidate for intracellular drug delivery in the treatment of tumors or localized infection.

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Section: Discussionmentioning

confidence: 99%

Influence of polymer size, liposomal composition, surface charge, and temperature on the permeability of pH-sensitive liposomes containing lipid-anchored poly(2-ethylacrylic acid)

Lu¹,

Wang²,

Ma³

et al. 2012

IJN

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“…In addition, these carriers are stable under physiological conditions and release drugs rapidly when subjected to mild hyperthermia. [63][64][65] Lysolipids are another material of interest that has been extensively used in liposomal drug delivery. Lysolipids like MPPC, when incorporated into the phospholipid bilayer, allow the stabilization of long-lasting pores thereby leading to rapid drug release.…”

Section: Temperature-sensitive Liposomesmentioning

confidence: 99%

Liposomes: Versatile and Biocompatible Nanovesicles for Efficient Biomolecules Delivery

Mallick¹,

Choi²

2014

j. nanosci. nanotech.

135

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Since the revolutionary discovery that phospholipids can form closed bilayered structures in aqueous systems, liposomes have become a very interesting topic of research. Because of their versatility and amazing biocompatibility, the use of liposomes has been widely accepted in many scientific disciplines. Their applications, especially in medicine, have yielded breakthroughs with anticancer-drug carriers over the past few decades. Specifically, their easy preparation and various structural aspects have given rise to a broadly usable way to internalize biomolecules such as drugs, DNA, RNA and even imaging probes. This review article reports recent developments in liposomal drug delivery and gene delivery, and thoroughly covers the synthesis and different kinds of liposomal surface modification techniques that have resulted in higher stability and efficiency with respect to the use of liposomes in tumor cell targeting, site-specific release, and extending blood retention times.

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“…Enhancement in triggered drug-release due to dual responsiveness to pH and temperature has been shown for ionically self-assembled NPs and liposomes (Ta et al, 2010;Cui et al, 2012). Another system has shown responsiveness to both ultrasound and enzymes to enhance drug release from bubble liposomes (Nahire et al, 2012).…”

Section: Magnetic-responsive Polymersmentioning

confidence: 99%

Classification of stimuli–responsive polymers as anticancer drug delivery systems

et al. 2014

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Although several anticancer drugs have been introduced as chemotherapeutic agents, the effective treatment of cancer remains a challenge. Major limitations in the application of anticancer drugs include their nonspecificity, wide biodistribution, short half-life, low concentration in tumor tissue and systemic toxicity. Drug delivery to the tumor site has become feasible in recent years, and recent advances in the development of new drug delivery systems for controlled drug release in tumor tissues with reduced side effects show great promise. In this field, the use of biodegradable polymers as drug carriers has attracted the most attention. However, drug release is still difficult to control even when a polymeric drug carrier is used. The design of pharmaceutical polymers that respond to external stimuli (known as stimuli-responsive polymers) such as temperature, pH, electric or magnetic field, enzymes, ultrasound waves, etc. appears to be a successful approach. In these systems, drug release is triggered by different stimuli. The purpose of this review is to summarize different types of polymeric drug carriers and stimuli, in addition to the combination use of stimuli in order to achieve a better controlled drug release, and it discusses their potential strengths and applications. A survey of the recent literature on various stimuli-responsive drug delivery systems is also provided and perspectives on possible future developments in controlled drug release at tumor site have been discussed.

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Thermosensitive Liposomes Modified with Poly(N-isopropylacrylamide-co-propylacrylic acid) Copolymers for Triggered Release of Doxorubicin

Cited by 117 publications

References 30 publications

Influence of polymer size, liposomal composition, surface charge, and temperature on the permeability of pH-sensitive liposomes containing lipid-anchored poly(2-ethylacrylic acid)

Influence of polymer size, liposomal composition, surface charge, and temperature on the permeability of pH-sensitive liposomes containing lipid-anchored poly(2-ethylacrylic acid)

Liposomes: Versatile and Biocompatible Nanovesicles for Efficient Biomolecules Delivery

Classification of stimuli–responsive polymers as anticancer drug delivery systems

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