Thermosensitive Lipid Bilayer-Coated Mesoporous Carbon Nanoparticles for Synergistic Thermochemotherapy of Tumor

Abstract

Thermochemotherapy exhibits a synergistic therapeutic efficiency for cancer, and the sensitivity of cancer cells to chemical drugs could be increased to a large extent at elevated temperature. In this work, a biocompatible nanocomposite thermosensitive mesoporous carbon nanoparticles (TSMCN) was prepared by covering a liposome on mesoporous carbon nanoparticles (MCN). The TSMCN had good photothermal efficiency and photostability. The doxorubicin (DOX)-loaded TSMCN (DOX/TSMCN) showed a slower release than the DOX-loaded MCN-COOH (DOX/MCN-COOH) both in simulated tumor environment and physiological environment. And release curves of DOX/TSMCN exposed to NIR laser exhibited the fast release property. The confocal laser scanning microscopy results illustrated that cellular uptake of DOX for DOX/TSMCN can be enhanced by NIR laser. The temperature of the tumor site reached up to 51.9 °C within 3 min after exposure to laser at 1.25 W/cm power density, which is above the phase transition temperature ( T) of liposome (40.7 °C). The biodistribution of DOX in vivo indicated that NIR laser can prolong the retardation time of DOX in the tumor site. The results of both 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide and antitumor efficiency elucidated that the DOX/TSMCN under NIR irradiation had a synergistic therapeutic effect for cancer. Thus, the TSMCN could be explored as a powerful nanoplatform that shows great prospect in thermochemotherapy of tumor therapy.

<p>Multifunctional Mesoporous Polydopamine With Hydrophobic Paclitaxel For Photoacoustic Imaging-Guided Chemo-Photothermal Synergistic Therapy</p>

“…The drastic release of PTX is mainly due to the rapid temperature increasing of MPDA-PEG dispersion under NIR irradiation, which facilitates the PTX molecule thermal motion and the escape of PTX molecules from the mesochannels of MPDA-PEG nanoparticles 12. The above result clearly indicates that MPDA-PEG-PTX nanoparticles exhibit NIR-responsive drug release behavior, the elevated temperature can facilitate the release of chemotherapeutic drugs in tumor site, increasing the bioavailability of PTX and decreasing the side effect, producing synergistic therapeutic effect 47–50…”

Near-infrared photoresponsive drug delivery nanosystems for cancer photo-chemotherapy

“…As such, CuS-DOX-MBA@PCM afforded a high efficacy in killing A549 cancer cells and inhibiting growth of ehrlich ascites carcinoma (EAC) tumors in living mice after NIR-triggered drug release. In another study, Wang and Zhao et al developed a thermosensitive liposome bilayers coated mesoporous carbon nanoparticle (MCN) to achieve NIR light triggered on-demand release of DOX for synergistic cancer PTT-chemotherapy [ 58 ]. 1,2-Distearoyl-sn-glycero-3-phosphoethanolamine- N -[amino(poly(ethylene glycol))] (DSPE-PEG), 1-stearoyl-2-hydroxy-sn-glycero-3-phosphatidylcholine (MSPC), and 1,2-dipalmitoyl-sn-glycero-3-phosphatidylcholine (DPPC) were used to construct surface liposome bilayers with a phase transition temperature (T m ) of 40.7 °C.…”

Ecotoxicidade de nanocatalisadores de óxidos de ferro, produzidos a partir da drenagem ácida de mina, quando submetidos à ação de ozônio em meio aquoso

“…O impacto ambiental causado pelo lançamento não controlado de Fe-NP deve ser investigado, pois a passagem facilitada por meio de barreiras biológicas, devido ao seu menor tamanho, possibilita o seu acúmulo em vários tecidos e células, além de interação com diferentes tipos de compostos (DURÁN- VALDEIGT ESIAS et al, 2016;ZHU et al, 2017;EFRAMOVA et al, 2018;LI et al, 2018;SIDIROUPOLOU et al, 2018;HURTADO-GALLEGO et al, 2020;PAUNOVIC et al, 2020;SAYADI et al, 2020).…”