Thermosensitive chitosan as an injectable carrier for local drug delivery

Bae, Jin Woo; Go, Dong Hyun; Парк, Ки Донг; Lee, Seung Jin

doi:10.1007/bf03219111

Cited by 50 publications

(35 citation statements)

References 19 publications

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“…Due to the interesting dual-responsive behaviour of Cs-g-PNIPAm copolymers, the properties of these materials have been thoroughly studied using different techniques such as microdifferential scanning calorimetry (μDSC), dynamic light scattering (DLS), NMR, UV-Vis spectroscopy and rheological measurements, among others [46,51,52,54,[58][59][60][62][63][64][65].…”

Section: Propertiesmentioning

confidence: 99%

Chitosan-Based Thermosensitive Materials

Argüelles‐Monal¹,

Recillas-Mota²,

Fernández‐Quiroz³

2017

Biological Activities and Application of Marine Polysaccharides

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Thermosensitive polymers are materials capable of undergoing a reversible phase transition in aqueous media in response to a variation of the temperature. They have attracted high scientific interest for advanced applications in diverse areas, such as biotechnology, biomedical, environmental, food industry and other fields. At the same time, chitosan is a promising marine polysaccharide that has long been used in applications such as drug, peptide or gene delivery systems. Being the most abundant marine polysaccharide, chitin and chitosan do not exhibit thermoresponsive properties, but some of their derivatives do. In the present chapter, the efforts to produce chitosan-based thermosensitive materials are reviewed. Particularly, the properties and applications of chitosan-glycerophosphate thermogelling system are examined; the methods of synthesis of chitosan copolymers grafted with poly(Nisopropylacrylamide) or poly(N-vinylcaprolactam), their physicochemical properties and most of their prominent applications are discussed as well.

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Section: Propertiesmentioning

confidence: 99%

Chitosan-Based Thermosensitive Materials

Argüelles‐Monal¹,

Recillas-Mota²,

Fernández‐Quiroz³

2017

Biological Activities and Application of Marine Polysaccharides

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“…[3] Poly(Nisopropylacrylamide), poly(ethylene glycol)-block-poly-(propylene glycol)-block-poly(ethylene glycol) (Pluronic 1 ), and poly(ethylene glycol)/poly(ester) block copolymers and its analogs have been reported as thermosensitive polymers. [4][5][6][7][8][9][10][11][12][13][14] In polymers such as these, the temperature range for sol-gel transition can be formed near the body temperature by modulating the balance between hydrophilic and hydrophobic moieties of polymers, realizing scaffolding through injection into the body. [1,3] However, synthetic thermosensitive polymers are restricted in use as scaffolds for tissue regeneration because those generally do not retain any bioactive site for specific interaction with the cell or the growth factor.…”

Section: Introductionmentioning

confidence: 99%

Tetronic–Oligolactide–Heparin Hydrogel as a Multi‐Functional Scaffold for Tissue Regeneration

Joung

Lee

et al. 2008

Macromolecular Bioscience

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A novel cell-supporting scaffold, Tetronic-oligolactide-heparin (TLH) hydrogel, was prepared by coupling heparin to polymerized Tetronic-oligolactide for use in improving tissue regeneration. Aqueous TLH solutions showed thermosensitive behavior, demonstrating potential for use as injectable hydrogels. The content and activity of conjugated heparin were determined to be 61 wt.-% of total polymer and 67.2% of intact heparin activity, respectively. The basic fibroblast growth factor (bFGF) binding assay showed TLH hydrogel had a relatively high bFGF affinity, which indicates applicability for growth factor delivery. Chondrocyte culture on hydrogels revealed that the cell viability and the amount of synthesized glycosaminoglycan for TLH hydrogel were higher than those for alginate gel.

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“…Especially chitosan has recently been studied as a novel carrier material in drug or gene delivery systems. [1][2][3][4][5][6][7][8][9][10] But in such applications, chitosan has shown some inherent limitations of, for instance, the lack of water solubility 11 and the need of linker for higher drug loading. Various chemical modifications of chitosans have thus been adopted in order to widen their uses in various medical applications.…”

Section: Introductionmentioning

confidence: 99%

Regioselective succinylation and gelation behavior of glycol chitosan

et al. 2008

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Chitosan is normally acylated and subsequently conjugated with drugs for biomedical applications. This study examined the relationship between the succinylation and gelation behaviors of glycol chitosan. Glycol chitosan was acylated with succinic anhydride under a wide variety of reaction conditions, such as different molar ratios of succinic anhydride to glucosamine, different methanol content in the reaction media, and different reaction temperatures. Among these reaction parameters, the methanol content in the solvent played an important role in determining the regioseletive succinylating site. N-succinylation and N-N cross-linking occurred regardless of the reaction conditions. However, O-succinylation was observed under specific conditions, i.e. a methanol content > 0.6 (v/v) and a reaction temperature > 25 o C. O-succinylation accelerated the N-O cross-linking of glycol chitosan, and led to gelation. The N-succinylated glycol chitosans were water-soluble, whereas the N-and O-succinylated glycol chitosans formed a gel. These physico-chemical structural differences in the succinylated glycol chitosans would definitely influence subsequent drug-conjugation reactions and consequently the drug loading and release kinetics.

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Thermosensitive chitosan as an injectable carrier for local drug delivery

Cited by 50 publications

References 19 publications

Chitosan-Based Thermosensitive Materials

Chitosan-Based Thermosensitive Materials

Tetronic–Oligolactide–Heparin Hydrogel as a Multi‐Functional Scaffold for Tissue Regeneration

Regioselective succinylation and gelation behavior of glycol chitosan

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