Thermosensitive biomimetic polyisocyanopeptide hydrogels may facilitate wound repair

Veld, Roel C. op ‘t; Boomen, Onno I. van den; Lundvig, Ditte M. S.; Bronkhorst, Ewald M.; Kouwer, Paul H. J.; Jansen, John A.; Middelkoop, Esther; Hoff, Johannes W. Von den; Rowan, Alan E.; Wagener, Frank A. D. T. G.

doi:10.1016/j.biomaterials.2018.07.038

Cited by 101 publications

(90 citation statements)

References 50 publications

(46 reference statements)

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“…In this regard, the stimuli-responsive materials with tunable properties, which are also called ‘intelligent materials’, are ideal model systems for investigating cell migration in order to simulate the dynamic behaviors in vivo . The structures and properties of stimuli-responsive materials can be changed by various environmental stimuli [13] such as pH [14], light [15], redox [16], temperature [17] and enzymes [18]. In particular, the light-responsive materials have been widely studied in biomedical applications including anti-bacteria [19] and drug delivery [20] because of the versatilities in light wavelength, intensity, location and time [21].…”

Section: Introductionmentioning

confidence: 99%

Migration of endothelial cells into photo-responsive hydrogels with tunable modulus under the presence of pro-inflammatory macrophages

Cao

Zuo

et al. 2019

Regenerative Biomaterials

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Cell migration in three-dimensional environment is extremely important for tissue regeneration and other biological processes. In this work, a model system was developed to study how endothelial cells (ECs) migrate into photo-responsive hydrogels under the presence of pro-inflammatory macrophages. The hydrogel was synthesized from hyaluronic acid grafted with coumarin and methacrylate moieties by both carbon–carbon covalent linking and coumarin dimerization under UV irradiation at 365 nm. The structure of the hydrogel was conveniently modulated by UV irradiation at 254 nm to decompose the coumarin dimers, leading to the significant decrease of modulus and increase of swelling ratio and mesh size. Under the presence of M1 macrophages, ECs were induced to migrate into the hydrogels with a different degree. A significant larger net displacement of ECs was found in the softer hydrogel obtained by irradiation with UV at 254 nm than in the stiffer original one at day 7.

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Section: Introductionmentioning

confidence: 99%

Migration of endothelial cells into photo-responsive hydrogels with tunable modulus under the presence of pro-inflammatory macrophages

Cao

Zuo

et al. 2019

Regenerative Biomaterials

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“…Moreover, there were no significant differences in myofibroblasts, epithelial migration and macrophages levels, collagen expression, and blood vessels. The authors conclude that these biomimetic PIC hydrogels could be suitable for development into wound dressings [93]. PIC materials would be tailored to meet different requirements of cells by tuning the stiffness or through the grafting of the polymer with short GRGDS peptides using click chemistry.…”

Section: Synthetic Thermoresponsive Materialsmentioning

confidence: 99%

Stimuli-Responsive Materials for Tissue Engineering and Drug Delivery

Municoy

Echazú

Antezana

et al. 2020

IJMS

143

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Smart or stimuli-responsive materials are an emerging class of materials used for tissue engineering and drug delivery. A variety of stimuli (including temperature, pH, redox-state, light, and magnet fields) are being investigated for their potential to change a material’s properties, interactions, structure, and/or dimensions. The specificity of stimuli response, and ability to respond to endogenous cues inherently present in living systems provide possibilities to develop novel tissue engineering and drug delivery strategies (for example materials composed of stimuli responsive polymers that self-assemble or undergo phase transitions or morphology transformations). Herein, smart materials as controlled drug release vehicles for tissue engineering are described, highlighting their potential for the delivery of precise quantities of drugs at specific locations and times promoting the controlled repair or remodeling of tissues.

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“…Different types of scaffolds are available prepared from a wide range of biomaterials. Skin and muscle scaffolds can be of natural origins such as fibrin, alginate or collagen, or can be synthetic such as polypropylene, polyesters, polyurethanes, and polyisocyanopeptide hydrogel . They can be produced with a variety of methods, such as 3D printing and electro‐spinning.…”

Section: Clinical Challenges For Scaffold‐based Cord Blood Stem Cellsmentioning

confidence: 99%

“…Skin and muscle scaffolds can be of natural origins such as fibrin, alginate or collagen, or can be synthetic such as polypropylene, polyesters, polyurethanes, and polyisocyanopeptide hydrogel. 178,179 They can be produced with a variety of methods, such as 3D printing and electro-spinning. Synthetic biomaterials can be degradable or nondegradable.…”

Section: Clinical Challenges For Scaffold-based Cord Blood Stem Celmentioning

confidence: 99%

Tissue engineering strategies combining molecular targets against inflammation and fibrosis, and umbilical cord blood stem cells to improve hampered muscle and skin regeneration following cleft repair

Schreurs

Suttorp

Mutsaers

et al. 2019

Medicinal Research Reviews

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Cleft lip with or without cleft palate is a congenital deformity that occurs in about 1 of 700 newborns, affecting the dentition, bone, skin, muscles and mucosa in the orofacial region. A cleft can give rise to problems with maxillofacial growth, dental development, speech, and eating, and can also cause hearing impairment. Surgical repair of the lip may lead to impaired regeneration of muscle and skin, fibrosis, and scar formation. This may result in hampered facial growth and dental development affecting oral function and lip and nose esthetics. Therefore, secondary surgery to correct the scar is often indicated. We will discuss the molecular and cellular pathways involved in facial and lip myogenesis, muscle anatomy in the normal and cleft lip, and complications following surgery. The aim of this review is to outline a novel molecular and cellular strategy to improve musculature and skin regeneration and to reduce scar formation following cleft repair. Orofacial clefting can be diagnosed in the fetus through prenatal ultrasound screening and allows planning for the harvesting of umbilical cord blood stem cells upon birth. Tissue engineering techniques using these cord blood stem cells and molecular targeting of inflammation and fibrosis during surgery may promote tissue regeneration. We expect that this novel strategy improves both muscle and skin regeneration, resulting in better function and esthetics after cleft repair.

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Thermosensitive biomimetic polyisocyanopeptide hydrogels may facilitate wound repair

Cited by 101 publications

References 50 publications

Migration of endothelial cells into photo-responsive hydrogels with tunable modulus under the presence of pro-inflammatory macrophages

Migration of endothelial cells into photo-responsive hydrogels with tunable modulus under the presence of pro-inflammatory macrophages

Stimuli-Responsive Materials for Tissue Engineering and Drug Delivery

Tissue engineering strategies combining molecular targets against inflammation and fibrosis, and umbilical cord blood stem cells to improve hampered muscle and skin regeneration following cleft repair

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