Thermoresponsive surfaces for cell culture and enzyme-free cell detachment

Silva, Amanda; Richard, Cyrille; Bessodes, Michel; Scherman, Daniel; Merten, Otto‐Wilhelm

doi:10.1016/j.progpolymsci.2010.07.007

Cited by 112 publications

(82 citation statements)

References 119 publications

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“…and pluronics [189] changes wettability by surface-bound molecular motions, ultimately leading to promoted responses of boneassociated cells [190]. Hydrogel forms or microspherical and nanofibrillar structures are some of the applications of the stimuliresponsiveness materials for on-demand drug delivery.…”

Section: Stimuli-responsive Scaffoldsmentioning

confidence: 99%

Therapeutically relevant aspects in bone repair and regeneration

et al. 2015

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Over the past few years, attention has been focused on the therapeutic roles in designing bone scaffolds for successful repair and regeneration. Indeed, biologically dynamic events in the bone healing process involve many of the molecules and cells adherent to the scaffold. Recent bone scaffolds have been designed considering intrinsic chemical and physical factors and exogenous/extrinsic cues that induce bone regeneration. Here, we attempt to topically review the current trends and to suggest featured strategies for the design of therapeutically relevant bone scaffolds taking into account recent studies and applications.

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Section: Stimuli-responsive Scaffoldsmentioning

confidence: 99%

Therapeutically relevant aspects in bone repair and regeneration

et al. 2015

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“…Thus, the lowest temperature of the phase separation curve on the concentration-temperature diagram is called lower critical solution temperature (LCST). [1] Nowadays, these systems are of great interest, overall in biomedical and pharmaceutical fields, [2][3][4][5][6][7][8] since temperature is easy to be controlled for in vitro and in vivo applications.…”

Section: Introductionmentioning

confidence: 99%

Thermoresponsive Behavior of Mixtures of Epoxy Functionalized Oligo(ethylene glycol) Methacrylate Copolymers

París

Liras

Quijada‐Garrido

2011

Macro Chemistry & Physics

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Thermoresponsive random copolymers based on 2‐(2‐methoxyethoxy)ethyl methacrylate (MEO2MA) and oligo(ethylene glycol) methyl ether methacrylate (OEG8‐9MA) are synthesized by atom transfer radical polymerization (ATRP). In a second step, they are used as macroinitiators for the ATRP of glycidyl methacrylate (GMA), introducing a short end‐block with epoxy functionalities that allows the connection of the thermoresponsive polymers to a variety of molecules, surfaces, or particles. The resulting epoxy functionalized terpolymers exhibit lower critical solution temperatures (LCST), which can be adjusted by changing the feed monomer ratio of MEO2MA and OEG8‐9MA. Binary blends show one or two cloud points depending on the blend composition. A model for the polymer collapse in one mixed particle or in two different particles as function of composition is proposed. magnified image

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“…Grafting may be also analyzed via nuclear magnetic resonance, Fourier transform infrared spectroscopy, and surface-enhanced Raman spectroscopy, thermogravimetric analysis, elemental analysis and X-ray photoelectron spectroscopy. Additionally, by combining multi-angles laser light scattering, dynamic light scattering, microscopy techniques and small-angle X-ray scattering, physical characteristics of size, shape, and assembly behavior of the nanosystems can be elucidated 7, 64-67…”

Section: Structure-function Of Polysaccharides and Features Of Nanopamentioning

confidence: 99%

Polysaccharide Nanosystems for Future Progress in Cardiovascular Pathologies

Silva¹,

Letourneur²,

Chauvierre³

2014

Theranostics

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Natural polysaccharides have received a lot of attention in the biomedical field. Indeed, sources of polysaccharides, extracted or produced from plants, bacteria, fungi or algae, are diverse and renewable. Moreover, recent progresses in polysaccharide chemistry and nanotechnologies allow elaborating new dedicated nanosystems. Polysaccharide-based nanosystems may be designed for interacting in several biological processes. In particular, the atherothrombotic pathology is highly concerned by polysaccharide-mediated recognition. Atherothrombotic diseases, regardless of the anatomical localization, remain the main causes of morbidity and mortality in the industrialized world. This review intends to provide an overview on polysaccharide-based nanosystems as drug delivery systems and targeted contrast agents for molecular imaging with an emphasis on the treatment and imaging of cardiovascular pathologies.

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Thermoresponsive surfaces for cell culture and enzyme-free cell detachment

Cited by 112 publications

References 119 publications

Therapeutically relevant aspects in bone repair and regeneration

Therapeutically relevant aspects in bone repair and regeneration

Thermoresponsive Behavior of Mixtures of Epoxy Functionalized Oligo(ethylene glycol) Methacrylate Copolymers

Polysaccharide Nanosystems for Future Progress in Cardiovascular Pathologies

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