Thermoresponsive polyamic acid-conjugated gold nanocarrier for enhanced light-triggered 5-fluorouracil release

Hsiao, Pa Fan; Anbazhagan, Rajeshkumar; Chou, Hsiao-Ying; Vadivelmurugan, Adhishankar; Tsai, Hsieh‐Chih

doi:10.1039/c6ra27563j

Cited by 6 publications

(1 citation statement)

References 28 publications

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“…[26][27][28][29][30] These targeting systems show good efficiency in their internalization and biocompatibility; however, the large size of these macromolecule-based systems does not facilitate intravenous delivery. 31 In order to effectively pass a NPs-folate-conjugated system from the blood stream and reach the target cell of interest, their size and colloidal stability in the physiological environment should be considered as important factors. 35 The closest chemical formula of FA is C 19 H 19 N 7 O 6 (Mw =441.4 Da).…”

Section: Fa Release From Au-npsmentioning

confidence: 99%

<p>A review of small molecules and drug delivery applications using gold and iron nanoparticles</p>

Jahangirian¹,

Kalantari²,

Izadiyan³

et al. 2019

IJN

170

106

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Conventional cancer treatment techniques show several limitations including low or no specificity and consequently a low efficacy in discriminating between cancer cells and healthy cells. Recent nanotechnology developments have introduced smart and novel therapeutic nanomaterials that take advantage of various targeting approaches. The use of nanotechnology in medicine and, more specifically, drug delivery is set to spread even more rapidly than it has over the past two decades. Currently, many nanoparticles (NPs) are under investigation for drug delivery including those for cancer therapy. Targeted nanomaterials bind selectively to cancer cells and greatly affect them with only a minor effect on healthy cells. Gold nanoparticles (Au-NPs), specifically, have been identified as significant candidates for new cancer therapeutic modalities because of their biocompatibility, easy functionalization and fabrication, optical tunable characteristics, and chemophysical stability. In the last decade, there has been significant research on Au-NPs and their biomedical applications. Functionalized Au-NPs represent highly attractive and promising candidates for drug delivery, owing to their unique dimensions, tunable surface functionalities, and controllable drug release. Further, iron oxide NPs due to their "superparamagnetic" properties have been studied and have demonstrated successful employment in numerous applications. In targeted drug delivery systems, drug-loaded iron oxide NPs can accumulate at the tumor site with the aid of an external magnetic field. This can lead to incremental effectiveness in drug release to the tumor site and vanquish cancer cells without harming healthy cells. In order for the application of iron oxide NPs in the human body to be realized, they should be biodegradable and biocompatible to minimize toxicity. This review illustrates recent advances in the field drug and small molecule delivery such as fluorouracil, folic acid, doxorubicin, paclitaxel, and daunorubicin, specifically when using gold and iron oxide NPs as carriers of anticancer therapeutic agents.

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Section: Fa Release From Au-npsmentioning

confidence: 99%

<p>A review of small molecules and drug delivery applications using gold and iron nanoparticles</p>

Jahangirian¹,

Kalantari²,

Izadiyan³

et al. 2019

IJN

170

106

View full text Add to dashboard Cite

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NMR-based structural characterization of common aromatic poly(amic acid) polymers

Yazgan

2019

Polym. Bull.

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Multi-walled carbon nanotubes/polypyrrole nanocomposite, synthesized through an eco-friendly route, as a prospective drug delivery system

et al. 2022

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Thermoresponsive polyamic acid-conjugated gold nanocarrier for enhanced light-triggered 5-fluorouracil release

Abstract: In this study, a light-responsive 5-fluorouracil (5-FU) drug carrier system was developed by combining gold nanoparticles with thermosensitive hydrophilic polyamic acid.

Cited by 6 publications

References 28 publications

<p>A review of small molecules and drug delivery applications using gold and iron nanoparticles</p>

<p>A review of small molecules and drug delivery applications using gold and iron nanoparticles</p>

NMR-based structural characterization of common aromatic poly(amic acid) polymers

Multi-walled carbon nanotubes/polypyrrole nanocomposite, synthesized through an eco-friendly route, as a prospective drug delivery system

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