Thermoresponsive DNA by Intercalation of dsDNA with Oligoethylene‐Glycol‐Functionalized Small‐Molecule Intercalators

Abstract

Thermoresponsive polymeric materials are important building blocks for smart materials. In this work, the transformation of dsDNA into a thermoresponsive polymer is reported by intercalation of short, oligoethylene‐glycol‐modified proflavine intercalators. The thermoresponsiveness of the dsDNA‐intercalator complex originates from the heating‐induced dehydration of the ethylene glycol side chains, which leads to aggregation of the intercalated dsDNA. This work demonstrates the possibility of designing small‐molecule intercalators to prepare thermoresponsive dsDNA complexes with tunable lower critical solution temperature behavior.

DNA Interaction Study of Some Symmetrical 1,2-Phenylenediamine Schiff’s Base Derivatives as New Potential DNA Intercalators Using Ethidium Bromide Competition Fluorescent Assay

“…The second mode of interaction is called groove binding in which the targeting molecules interact with DNA in base edges of minor or major grooves [3][4][5][6]. The third mode of interaction is intercalation that is closely related to the antitumor ability of several anticancer drugs [7][8][9].Intercalators are ligands interacting with the DNA double helix in a reversible manner. Many of them are currently used as powerful drugs for the treatment of breast and ovarian cancers, acute leukemia, and many others are still in clinical trials.…”

“…The second mode of interaction is called groove binding in which the targeting molecules interact with DNA in base edges of minor or major grooves [3][4][5][6]. The third mode of interaction is intercalation that is closely related to the antitumor ability of several anticancer drugs [7][8][9].…”