DNA Interaction Study of Some Symmetrical 1,2-Phenylenediamine Schiff’s Base Derivatives as New Potential DNA Intercalators Using Ethidium Bromide Competition Fluorescent Assay
Abstract:Several biological experiments proposed that DNA is one of the principal cellular targets for numerous anticancer agents. Mainly, in cancer cells, DNA could be selectively damaged, as a result of interactions with anticancer agents, consequently blocking of cell division leads to cell death [1,2]. The molecules that interact with DNA are generally bound to DNA through non-covalent bonds by three main mechanisms: groove binding, intercalation or static electronic interactions. Static electronic interactions cou… Show more
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