Thermoregulation After Trauma

Stoner, H. B.

doi:10.1016/b978-0-08-027347-1.50007-4

Cited by 3 publications

(3 citation statements)

References 31 publications

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“…In this respect the effect of trauma in man was different from that seen in some thermoregulatory responses in the rat. In that species trauma inhibits both thermoregulatory heat production and loss, widening the temperature gap between the thresholds for the onset of thermoregulatory heat production and heat loss (Stoner, 1981). However, in this case the regression lines, against Tag showing the intensity of shivering (Stoner, 1971), total oxygen consumption (Stoner, 1969) and non-shivering thermogenesis (Stoner, 1974) were displaced to the left without change in slope.…”

Section: Discussionmentioning

confidence: 91%

“…When our results are considered in the light of other work on the effect of trauma on thermoregulation (Stoner, 1981) and cardiovascular homoeostatis (Little et al 1984a;Redfern et al 1984) it seems likely that they reflect changes in control mechanisms within the central nervous system. Three features of injury might be involved: loss of fluid from the circulation into the damaged tissue, the production of endogenous pyrogens and nociceptive afferent impulses.…”

Section: Discussionmentioning

confidence: 99%

“…However, much less is known about the effect of tissue trauma on thermoregulation in man than in small mammals. The disturbance in the rat, injured by limb ischaemia, is known in considerable detail, even to the neural pathways and some of the transmitters involved (see Stoner (1981) for review). The central neuronal network which controls body temperature in man is probably much the same as in the rat but the relative importance of the peripheral effectors is different.…”

Section: Introductionmentioning

confidence: 99%

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An Effect of Injury on Thermoregulation in Man

et al. 1986

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SUMMARYThe effect of trauma on human thermoregulation has been studied using a behavioural test and the vascular response to cold exposure. It was confirmed, in controls, that a pleasurable temperature for the hand (Thand) depended on core temperature (T7) to which it was negatively related. Shortly after moderately severe fractures in a leg this relationship was lost and in the patients the slope of this regression line was not significantly different from zero and they usually chose a Thand towards the upper end of the normal range irrespective of T7. This effect was not imitated in controls by removing 500 ml blood but Thand was increased by occluding the circulation to one leg. Naloxone did not alter Thand in controls but when given in a suitable dose it reduced the rise in Thand during a short period of limb ischaemia. Immersing one hand and forearm in water at 17°C reduced the blood flow through the contralateral forearm and hand. The reduction in flow was positively related to the initial rate of flow in both controls and injured but the slope of the regression line was significantly less after injury. It is concluded that thermoregulation is affected by trauma in man.

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Section: Discussionmentioning

confidence: 91%