Neural pathways mediating the inhibition of shivering by nonthermal afferent impulses from ischemic limbs

Stoner, H. B.; Marshall, Hazel

doi:10.1016/0014-4886(82)90046-2

Cited by 4 publications

(3 citation statements)

References 16 publications

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“…From our previous work (Stoner & Marshall, 1982) it seems most likely that the afferent impulses responsible for the changes during limb ischaemia arise in polymodal receptors in the ischaemic muscle (Mense, 1977) and ascend to the spinal cord in non-myelinated group IV fibres which will survive, for a time, the pressure and the ischaemia of the tourniquets (Ochoa, Fowler & Gilliatt, 1972). Mense & Stahnke (1983) have recently analysed the behaviour of these muscle receptors and have characterized one as a nociceptive receptor (N-type) which transmits the pain of ischaemic muscle contractions and perhaps also impulses affecting reflex activity.…”

Section: Discussionmentioning

confidence: 99%

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Effect of Limb Ischaemia on Blood Pressure and the Blood Pressure‐heart Rate Reflex in the Rat

et al. 1984

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SUMMARYThe effects of bilateral hind-limb ischaemia on blood pressure and on the blood pressure-heart rate reflex have been studied in the rat. Limb ischaemia increased blood pressure and decreased the elevation and slope of the regression line describing the relationship between heart period (H.P.) and mean arterial pressure (M.A.P.). Nociceptive afferents from muscle receptors using long fibre tracts in the anterolateral part of the spinal cord seem to be responsible for the changes seen. The changes in the blood pressure-heart rate reflex were mediated by a combination of vagal inhibition and sympathetic activation. The efferent pathway for the pressor effect was in the sympathetic outflow. Central catecholaminergic neurones were involved in the pressor effect of limb ischaemia but not in the changes in the blood pressure-heart rate reflex. Electrolytic lesions in the posterior hypothalamus attenuated the inhibition of the reflex and it is suggested that neurones in the defence area may be activated by limb ischaemia. The interaction between limb ischaemia and the H.P.-M.A.P. relationship was not affected by opioid antagonists. After the period of ischaemia there was an increase in the elevation of the regression line describing the relationship between H.P. and M.A.P. which was secondary to the fall in body temperature characteristic of this phase of the response to injury.

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Section: Discussionmentioning

confidence: 99%

“…This part of the cord may be the common path for the rat in such circumstances. It contains fibres concerned in the inhibition of shivering by limb ischaemia (Stoner & Marshall, 1982) and in the neurohumoral response to hind-limb trauma (Allen, Allen & Greer, 1973).…”

Section: Discussionmentioning

confidence: 99%

Effect of Limb Ischaemia on Blood Pressure and the Blood Pressure‐heart Rate Reflex in the Rat

et al. 1984

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“…The mechanisms of these inhibitory effects are not known. Triggering is best seen in the inhibition of shivering by limb ischaemia in the rat where an effect lasting some hours is determined by events during the first quarter of an hour after application of the tourniquets (Stoner & Marshall, 1982).…”

Section: Physiological Responsesmentioning

confidence: 99%