Thermodynamics of β-cyclodextrin–ephedrine inclusion complex formation and covering of nanometric calcite with these substances

Wszelaka‐Rylik, Małgorzata

doi:10.1007/s10973-016-5467-x

Cited by 11 publications

(1 citation statement)

References 26 publications

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“…Thermal analysis enables to study interactions occurring inside supermolecular structures built from macromolecules (hosts) and ions/small molecules (guest ligands) [1][2][3][4][5][6]. Many research centers have carried out studies on the use of cucurbiturils as transporters of toxic medicines [7], including oncological drugs [8][9][10][11].…”

Section: Introductionmentioning

confidence: 99%

Calorimetric and spectroscopic investigations of interactions between cucurbituril Q7 and gemcitabine in aqueous solutions

Buczkowski

Stępniak

Urbaniak

et al. 2018

J Therm Anal Calorim

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Studies on the interactions between cucurbituril Q7 and gemcitabine (Gem) hydrochloride in water were carried out using isothermal titration calorimetry (ITC) and electrospray ionization-mass spectrometry (ESI-MS). According to ITC and ESI-MS, the formation of this complex occurs in both the solution containing excess gemcitabine and the solution containing excess cucurbituril Q7. ITC results confirm the formation of a thermodynamically stable supramolecular complex with stoichiometry 1:1. The inclusion mechanism of Gem inside the cucurbituril macromolecule is spontaneous (DG\0). This process is exothermic (DH\0) and is characterized by the loss of entropy (DS\0).

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