Thermodynamics of phase separation in aqueous solutions of polymers

Yu, Ming; Nishiumi, Hideo; Arons, J. de Swaan

doi:10.1016/0378-3812(93)87039-4

Cited by 25 publications

(25 citation statements)

References 15 publications

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“…Kretschmer and Wiebe (1954) and Nagata (1985). The other approach considers that the hydrocarbon molecule bonds only to a single cluster of solvent molecules, as in the treatment presented by Asprion et al (2003) and, by analogy, Yu et al (1993). The first approach introduces some mathematical difficulties which stand in the way of a rigorous solution of chemical equilibrium.…”

Section: Cross-association: Concepts and Equationsmentioning

confidence: 99%

A modified UNIQUAC equation for mixtures containing self-associating compounds

Filho

Mohamed

Maurer

2005

Braz. J. Chem. Eng.

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-The UNIQUAC model for the excess Gibbs energy is modified using chemical theory to account for chain-like association occurring in self-associating compounds such as alcohols. The equation considers the alcohol to be a mixture of clusters in chemical equilibrium. The UNIQUAC equation is used to model the behavior of the mixture of clusters, with size and surface parameters related to the number of alcohol molecules involved in their formation. The values of association enthalpy and entropy were obtained through fitting vapor pressure data. The model is used to correlate phase behavior of alcohol-hydrocarbon mixtures at low pressures, presenting excellent results in bubble point calculations. A further extension was made to allow for cross-association, the formation of a hydrogen bond between the molecules of an alcohol and an active solute. This extension was used to model alcohol-aromatic mixtures with equally good results.

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Section: Cross-association: Concepts and Equationsmentioning

confidence: 99%

A modified UNIQUAC equation for mixtures containing self-associating compounds

Filho

Mohamed

Maurer

2005

Braz. J. Chem. Eng.

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“…Therefore, it is important to understand the impact that details of the freezing stage may have on phase separation and the resulting implications for product quality. There are several well documented cases of polymer-polymer incompatibilities, [2][3][4][5][6] and it is speculated that such incompatibilities may exist in pharmaceutical systems, particularly in proteinstabilizer systems. [7][8][9][10] Separation of a protein from its stabilizer may result in process and/or storage instability.…”

Section: Introductionmentioning

confidence: 99%

The Study of Amorphous Phase Separation in a Model Polymer Phase-Separating System Using Raman Microscopy and a Low-Temperature Stage: Effect of Cooling Rate and Nucleation Temperature

Padilla

Chou

Luthra

et al. 2011

Journal of Pharmaceutical Sciences

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“…These critical constants are obtained by simultaneously solving Eqs. (15) and (16). The third criterion is the accuracy of predication of the binodal curve.…”

Section: Table 3amentioning

confidence: 99%

“…those based on the osmotic virial expansion [7], those based on equations of state [16,17], the group contribution schemes [18], and those based on the lattice mean field theory [11,[14][15][16][19][20][21][22][23][24]. Among these models, those based on the mean field theory are most widely used.…”

Section: Introductionmentioning

confidence: 99%

“…Two types of mean field models are reported. The first is the modified form of the Flory-Huggins theory [11,[14][15][16]19] and the second accounts for the thermodynamics of hydrogen bond formation [20][21][22][23][24]. A good thermodynamic model should be able to relate the activity of PEG solutions at low temperatures with its phase behavior at high temperatures.…”

Section: Introductionmentioning

confidence: 99%

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