Quantification of thermodynamics of aqueous solutions of poly(ethylene glycols): Role of calorimetry

Mohite, Lalaso V.; Juvekar, Vinay A.

doi:10.1016/j.fluid.2009.01.003

Cited by 13 publications

(12 citation statements)

References 32 publications

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“…Above 55 °C, the heat of dilution turned positive which is typical for UCST polymer‐water systems, see ref . PHEMA‐water mixtures resemble poly(ethylene glycol)‐water systems which are typical by the closed‐loop immiscibility gap in a certain range of molecular weights . It is conceivable that low molecular weight fractions of PHEMA may behave analogously.…”

Section: Resultsmentioning

confidence: 87%

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The Manifold Varieties of Poly(2‐Hydroxyethyl Methacrylate) Hydrogels−IPNs

Dušková‐Smrčková

Sadakbayeva

Steinhart

et al. 2017

Macromolecular Symposia

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Summary The interpenetrating network structure was used to control mechanical properties of hydrogels based on poly(2‐hydroxyethyl methacrylate) (PHEMA) (first network (A) or second network (B)) and poly(glycerol methacrylate) (PGMA) (network B). In order to understand the structure, mechanical and swelling properties of sequentially made IPN hydrogels, the swollen PHEMA network microstructure and its formation was investigated by means of swelling and SWAXS experiments. Visually clear and microscopically homogenous hydrogel networks based on poly(2‐hydroxyethyl methacrylate) revealed presence of domains of size 1–10 nm formed during polymerization in the presence of water. The study was carried out to understand conditions under which the hydrophobic interactions are operative and their effect on the microstructure as well as how they change when the double network structure is introduced. The morphologies of network A ranged from homogenous, non‐porous, and optically clear gels, to macroporous gels resulting from phase separation and offering fused‐sphere morphology. A cryogel characterized by large elongated and partially interconnected pores of tens to hundreds micrometers were another object for comparison. In most cases, an increase of tensile moduli and improvement of ultimate tensile properties was achieved. A surprisingly high increase in true strength (by a factor of 10 – 30) was achieved when the macroporous PHEMA network A was reinforced by weak PHEMA or PGMA networks B. All these weakly crosslinked IPN gels were optically clear.

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Section: Resultsmentioning

confidence: 87%

“…[39] PHEMAwater mixtures resemble poly(ethylene glycol)-water systems which are typical by the closed-loop immiscibility gap in a certain range of molecular weights. [40][41][42] It is conceivable that low molecular weight fractions of PHEMA may behave analogously. Alcohols are generally UCST solvents [43] and HEMA monomer is one of them.…”

Section: Resultsmentioning

confidence: 99%

The Manifold Varieties of Poly(2‐Hydroxyethyl Methacrylate) Hydrogels−IPNs

Dušková‐Smrčková

Sadakbayeva

Steinhart

et al. 2017

Macromolecular Symposia

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“…Except for interaction parameters χ*, χ, and χ′, all the other parameters of the model have been obtained from the literature and are listed in Table . PEG-water interaction parameters in the Flory–Huggins theory are used, polynomial based on polymer volume fraction in solution phase, and polymer area fraction in surface phase given below ( T is temperature expressed in Kelvin) where The coefficients of this polynomial b i ( T ) are temperature dependent.…”

Section: Resultsmentioning

confidence: 99%

“…We use this concentration profile in eq and estimate (γ – γ w )/ RT . The heat of dilution of PEG solution in the absence of solid is calculated using the methodology described by Mohite and Juvekar . This allows us to compute the integral heat of adsorption ΔQ̂ I to the first approximation.…”

Section: The Modelmentioning

confidence: 99%

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Quantification of Polymer–Surface Interaction Using Microcalorimetry

Mohite

Juvekar

Sahu

2018

Ind. Eng. Chem. Res.

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Isothermal titration microcalorimetry experiments are performed to measure the heat of adsorption of poly(ethylene glycol) (PEG) on nonporous silica nanoparticles. A calorimetric technique is also developed for the determination of the adsorption isotherm for the PEG−silica system. A model based on the continuum form of the selfconsistent field theory is used for estimating the polymer− surface interaction parameter, χ*, from the heat of adsorption of the polymer. The effect of temperature and molecular weight of PEG on χ* has been determined. It is shown that the adsorbed amount of PEG on silica, predicted using the estimated value of χ*, is in good agreement with the experimental data. We also find that the major contribution to the heat of adsorption arises from the bound fraction of the adsorbed polymer.

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Survey of the year 2009: applications of isothermal titration calorimetry

Falconer

Collins

2010

J. Mol. Recognit.

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Isothermal titration calorimetry (ITC) is now an established and invaluable method for determining the thermodynamic constants, association constant and stoichiometry of molecular interactions in aqueous solutions. The technique has become widely used by biochemists to study protein interaction with other proteins, small molecules, metal ions, lipids, nucleic acids and carbohydrates; and nucleic acid interaction with small molecules. The drug discovery industry has utilized this approach to measure protein (or nucleic acid) interaction with drug candidates. ITC has been used to screen candidates, guide the design of potential drugs and validate the modelling used in structure-based drug design. Emerging disciplines including nanotechnology and drug delivery could benefit greatly from ITC in enhancing their understanding and control of nano-particle assembly, and drug binding and controlled release.

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Quantification of thermodynamics of aqueous solutions of poly(ethylene glycols): Role of calorimetry

Cited by 13 publications

References 32 publications

The Manifold Varieties of Poly(2‐Hydroxyethyl Methacrylate) Hydrogels−IPNs

The Manifold Varieties of Poly(2‐Hydroxyethyl Methacrylate) Hydrogels−IPNs

Quantification of Polymer–Surface Interaction Using Microcalorimetry

Survey of the year 2009: applications of isothermal titration calorimetry

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