Thermodynamic study of ibuprofen by adiabatic calorimetry and thermal analysis

Xu, Fen; Sun, Lin; Tan, Zhi‐Cheng; Liang, Jian-Guo; Li, Rui-Lian

doi:10.1016/j.tca.2003.08.021

Cited by 51 publications

(40 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…, and other weak peaks at 750-1300 cm À1 can also be observed, [55] and confirm the successful adsorption of IBU onto the surface of the mesoporous [56] which further confirms loading of ibuprofen into the CaF 2 :Ce 3 + /Tb 3 + sample. The cumulative drug release profiles for the IBU-CaF 2 :Ce 3 + /Tb 3 + systems as a function of release time in simulated body fluid are shown in Figure 12 A.…”

supporting

confidence: 61%

Facile and Controllable Synthesis of Monodisperse CaF₂ and CaF₂:Ce³⁺/Tb³⁺ Hollow Spheres as Efficient Luminescent Materials and Smart Drug Carriers

Zhang

Peng

et al. 2010

Chemistry A European J

126

View full text Add to dashboard Cite

Highly uniform and well-dispersed CaF(2) hollow spheres with tunable particle size (300-930 nm) have been synthesized by a facile hydrothermal process. Their shells are composed of numerous nanocrystals (about 40 nm in diameter). The morphology and size of the CaF(2) products are strongly dependent on experimental parameters such as reaction time, pH value, and organic additives. The size of the CaF(2) hollow spheres can be controlled from 300 to 930 nm by adjusting the pH value. Nitrogen adsorption-desorption measurements suggest that mesopores (av 24.6 nm) exist in these hollow spheres. In addition, Ce(3+)/Tb(3+)-codoped CaF(2) hollow spheres can be prepared similarly, and show efficient energy transfer from Ce(3+) to Tb(3+) and strong green photoluminescence of Tb(3+) (541 nm, (5)D(4)-->(7)F(5) transition of Tb(3+), the highest quantum efficiency reaches 77%). The monodisperse CaF(2):Ce(3+)/Tb(3+) hollow spheres also have desirable properties as drug carriers. Ibuprofen-loaded CaF(2):Ce(3+)/Tb(3+) samples still show green luminescence of Tb(3+) under UV irradiation, and the emission intensity of Tb(3+) in the drug-carrier system varies with the released amount of ibuprofen, so that drug release can be easily tracked and monitored by means of the change in luminescence intensity. The formation mechanism and luminescent and drug-release properties were studied in detail.

show abstract

supporting

confidence: 61%

Facile and Controllable Synthesis of Monodisperse CaF₂ and CaF₂:Ce³⁺/Tb³⁺ Hollow Spheres as Efficient Luminescent Materials and Smart Drug Carriers

Zhang

Peng

et al. 2010

Chemistry A European J

126

View full text Add to dashboard Cite

show abstract

“…The available literature data as well as a few new measurements are summarized in Table 1. [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17] The enthalpies reported in Table 1 are all temperature dependent and all are reported at the temperatures noted in the table. As many of the measurements including the activation energy, vaporization, and sublimation enthalpy data have been measured at highly divergent temperatures, comparison of the consistency of these measurements is problematic.…”

Section: Introductionmentioning

confidence: 99%

“…Equations for the adjustment of phase transition enthalpies have been developed and are summarized as vap Hm(298 K) = sub Hm(298 K) − fus Hm(298 K) (1) sub Hm(298 K)/kJ · mol −1 = sub Hm(T m ) + 0.75 + 0.15 × C p (c) (T m − 298.15)/1000 (2) vap Hm(298 K)/kJ · mol −1 = vap Hm(T m ) + 10.58 + 0.26 C p (l) (T m − 298.15)/1000 (3) fus Hm(298 K)/kJ · mol −1 = fus Hm(T m ) + [0.15C p (c) − 0.26C p (l) − 9.93] (Tfus − 298.15) /1000 (4) Equation 1 is a thermodynamic equality used to evaluate vaporization enthalpies from the corresponding sublimation and fusion enthalpy provided that all enthalpies are adjusted to a common temperature. Eq.…”

Section: Introductionmentioning

confidence: 99%

An Examination of the Thermodynamics of Fusion, Vaporization, and Sublimation of Ibuprofen and Naproxen by Correlation Gas Chromatography

Maxwell

Chickos

2012

Journal of Pharmaceutical Sciences

View full text Add to dashboard Cite

“…Similar thermal behavior of ibuprofen had been reported in previous works, which demonstrated that evaporation started at approximately 158°C-190°C and ended at approximately 245.7°C-277°C, and the dTGA peak was at 243.3°C-255°C. 43,44 Therefore, this preparation technique did not alter the chemical properties and thermal behavior of ibuprofen, and the eutectic solvent was completely removed using this evaporation process. The rate of weight loss of ibuprofen nanocrystals (2.134%/°C) was higher than that of ibuprofen powder (1.924%/°C), which could be explained by the greater surface area of nanocrystal.…”

mentioning

confidence: 99%

Transformation of eutectic emulsion to nanosuspension fabricating with solvent evaporation and ultrasonication technique

Phaechamud

Tuntarawongsa

2016

IJN

View full text Add to dashboard Cite

Eutectic solvent can solubilize high amount of some therapeutic compounds. Volatile eutectic solvent is interesting to be used as solvent in the preparation of nanosuspension with emulsion solvent evaporation technique. The mechanism of transformation from the eutectic emulsion to nanosuspension was investigated in this study. The 30% w/w ibuprofen eutectic solution was used as the internal phase, and the external phase is composed of Tween 80 as emulsifier. Ibuprofen nanosuspension was prepared by eutectic emulsion solvent evaporating method followed with ultrasonication. During evaporation process, the ibuprofen concentration in emulsion droplets was increased leading to a drug supersaturation but did not immediately recrystallize because of low glass transition temperature ( T g ) of ibuprofen. The contact angle of the internal phase on ibuprofen was apparently lower than that of the external phase at all times of evaporation, indicating that the ibuprofen crystals were preferentially wetted by the internal phase than the external phase. From calculated dewetting value ibuprofen crystallization occurred in the droplet. Crystallization of the drug was initiated with external mechanical force, and the particle size of the drug was larger due to Ostwald ripening. Cavitation force from ultrasonication minimized the ibuprofen crystals to the nanoscale. Particle size and zeta potential of formulated ibuprofen nanosuspension were 330.87±51.49 nm and −31.1±1.6 mV, respectively, and exhibited a fast dissolution. Therefore, the combination of eutectic emulsion solvent evaporation method with ultrasonication was favorable for fabricating an ibuprofen nanosuspension, and the transformation mechanism was attained successfully.

show abstract

Thermodynamic study of ibuprofen by adiabatic calorimetry and thermal analysis

Cited by 51 publications

References 11 publications

Facile and Controllable Synthesis of Monodisperse CaF₂ and CaF₂:Ce³⁺/Tb³⁺ Hollow Spheres as Efficient Luminescent Materials and Smart Drug Carriers

Facile and Controllable Synthesis of Monodisperse CaF₂ and CaF₂:Ce³⁺/Tb³⁺ Hollow Spheres as Efficient Luminescent Materials and Smart Drug Carriers

An Examination of the Thermodynamics of Fusion, Vaporization, and Sublimation of Ibuprofen and Naproxen by Correlation Gas Chromatography

Transformation of eutectic emulsion to nanosuspension fabricating with solvent evaporation and ultrasonication technique

Contact Info

Product

Resources

About

Thermodynamic study of ibuprofen by adiabatic calorimetry and thermal analysis

Cited by 51 publications

References 11 publications

Facile and Controllable Synthesis of Monodisperse CaF2 and CaF2:Ce3+/Tb3+ Hollow Spheres as Efficient Luminescent Materials and Smart Drug Carriers

Facile and Controllable Synthesis of Monodisperse CaF2 and CaF2:Ce3+/Tb3+ Hollow Spheres as Efficient Luminescent Materials and Smart Drug Carriers

An Examination of the Thermodynamics of Fusion, Vaporization, and Sublimation of Ibuprofen and Naproxen by Correlation Gas Chromatography

Transformation of eutectic emulsion to nanosuspension fabricating with solvent evaporation and ultrasonication technique

Contact Info

Product

Resources

About

Facile and Controllable Synthesis of Monodisperse CaF₂ and CaF₂:Ce³⁺/Tb³⁺ Hollow Spheres as Efficient Luminescent Materials and Smart Drug Carriers

Facile and Controllable Synthesis of Monodisperse CaF₂ and CaF₂:Ce³⁺/Tb³⁺ Hollow Spheres as Efficient Luminescent Materials and Smart Drug Carriers