Thermodynamic models for determination of the solid-liquid equilibrium of istradefylline in ethyl acetate plus (isopropanol, tetrahydrofuran, acetone) binary solvent mixtures

Huang, Tianhua; Lu, Dingqiang; Ling, Xiuquan; Wang, Xinxian; Liu, Tongqi; Shen, Fang‐Fang; He, Kefei

doi:10.1016/j.jct.2017.03.015

Cited by 9 publications

(7 citation statements)

References 21 publications

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“…The Jouyban–Acree Model was a relatively universal model to suit the solubility with different temperatures and solvent compositions. − The equation is as follows …”

Section: Resultsmentioning

confidence: 99%

Determination and Analysis of Solubility of l-Prolinamide in Ten Pure Solvents and Three Binary Solvent Mixtures at Different Temperatures (T = 278.15–323.15 K)

Cui

Liang

et al. 2021

J. Chem. Eng. Data

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In this study, the data on solid−liquid equilibrium of L-prolinamide were studied using the gravimetric method. The solubility of L-prolinamide was measured in ten pure solvents (tetrahydrofuran, n-heptane, n-propanol, acetone, acetonitrile, ethyl acetate, N,N-dimethylformamide, n-hexane, cyclohexane, and isopropanol) and three binary solvent mixtures(ethyl acetate + tetrahydrofuran, n-heptane + ethyl acetate, and n-hexane + acetone) in the temperature range of 278.15−323.15 K at atmospheric pressure. The experimental values showed that the solubility increased with the increase of temperature in all solvents. The solubility data in different pure solvents were fitted using the modified Apelblat model and the Buchowski−Ksiazaczak λh model. For the solubility data of three binary solvent mixtures, the modified Apelblat model, the combined nearly ideal binary solvent/Redlich−Kister (CNIBS/R−K) model, and the Jouyban−Acree model were used to fit. In all four models, the modified Apelblat model had a better correlation with the solubility of L-prolinamide weather in pure solvents or binary solvent mixtures. The experimental results showed that n-heptane and n-hexane could be used as antisolvents, which could be used in the purification process of L-prolinamide and guide the large-scale production of many drugs such as Alpelisib in industries.

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“…The Jouyban–Acree Model was a relatively universal model to suit the solubility with different temperatures and solvent compositions. − The equation is as follows …”

Section: Resultsmentioning

confidence: 99%

Determination and Analysis of Solubility of l-Prolinamide in Ten Pure Solvents and Three Binary Solvent Mixtures at Different Temperatures (T = 278.15–323.15 K)

Cui

Liang

et al. 2021

J. Chem. Eng. Data

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“…The Jouyban–Acree model is the preferred equation for predicting the phase equilibrium of mixed solution systems. It can reflect the relationship among solubility, temperature, and solvent composition. , The equation is as follows: where J i is the parameter, and T (K) is the temperature of the mixed system during the experiment. The meanings of x , x A , x B , X A , and X B are consistent with eq .…”

Section: Resultsmentioning

confidence: 99%

“…All parameters of the model are listed in Tables 15−18. 21,22 The equation is as follows: where J i is the parameter, and T (K) is the temperature of the mixed system during the experiment. The meanings of x, x A , x B , X A , and X B are consistent with eq 6.…”

Section: Methodsmentioning

confidence: 99%

The Research and Measurement about the Solubility of l-Serine in Eight Common Pure Solvents and Four Binary Mixed Solvents for T = (278.15–333.15) K

Fan¹,

Zhu²,

Hu³

et al. 2019

J. Chem. Eng. Data

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In the study, the solubility of l-serine were measured in eight common pure solvents and binary mixed solvents (acetonitrile + water, isopropanol + water, methanol + water, and acetone + water) from 278.15 to 333.15 K under atmospheric pressure by gravimetric method (acetone was measured from 278.15 to 328.15 K). The solubility of l-serine increases with increasing temperature, and the order in eight common pure solvents is water > acetonitrile > methanol > acetone > ethyl acetate > ethanol > n-butanol > isopropanol. In binary mixed solvents, the solubility of l-serine is dependent on temperature and solvent composition. Also, the solubility of l-serine increases with increasing temperature, and it decreases as the concentration of acetonitrile, isopropanol, methanol, or acetone increases at a constant temperature. The experimental data in eight pure solvents were fitted by the modified Apelblat model, Buchowski–Ksiazaczak λh model. The modified Apelblat equation, combined nearly ideal binary solvent/Redlich–Kister (CNIBS/R–K) model, and Jouyban–Acree model were used to correlate the experimental data in four binary solvents. Among the four models, the modified Apelblat model is more suitable with a higher accuracy than the other three models. The experimental data can be used to optimize the industrial manufacturing process of l-serine.

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“…Зазвичай процеси синтезу та очищення твердих речовин відбуваються за участі індивідуальних розчинників або їх сумішей, тому оптимізація цих процесів є неможливою без визначення термодинамічних параметрів їх розчинення. В останні роки з'явилося багато робіт [1][2][3][4][5][6] з визначення термодинамічних властивостей розчинності сполук у ряді індивідуальних розчинників та їхніх сумішей. Представлена робота є однією з таких.…”

Section: вступunclassified

Термодинамічні Властивості Метил 6-Метил-2-Оксо-4- Феніл-1,2,3,4-Тетрагідропіримідин-5-Карбоксилату Та Його Розчинів В Етилацетаті І Бензолі Та Їх Сумішах

Ridka¹,

Matiychuk²,

Собечко³

et al. 2019

CTAS

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політехніка", кафедра фізичної аналітичної та загальної хімії 2 Львівський національний університет імені Івана Франка, кафедра органічної хімії 3 Інститут проблем матеріалознавства ім. І.М. Францевича НАНУ, відділ фізико-хімії і технології наноструктурної кераміки та нанокомпозитів

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Thermodynamic models for determination of the solid-liquid equilibrium of istradefylline in ethyl acetate plus (isopropanol, tetrahydrofuran, acetone) binary solvent mixtures

Cited by 9 publications

References 21 publications

Determination and Analysis of Solubility of l-Prolinamide in Ten Pure Solvents and Three Binary Solvent Mixtures at Different Temperatures (T = 278.15–323.15 K)

Determination and Analysis of Solubility of l-Prolinamide in Ten Pure Solvents and Three Binary Solvent Mixtures at Different Temperatures (T = 278.15–323.15 K)

The Research and Measurement about the Solubility of l-Serine in Eight Common Pure Solvents and Four Binary Mixed Solvents for T = (278.15–333.15) K

Термодинамічні Властивості Метил 6-Метил-2-Оксо-4- Феніл-1,2,3,4-Тетрагідропіримідин-5-Карбоксилату Та Його Розчинів В Етилацетаті І Бензолі Та Їх Сумішах

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