The Research and Measurement about the Solubility of l-Serine in Eight Common Pure Solvents and Four Binary Mixed Solvents for T = (278.15–333.15) K

Abstract

In the study, the solubility of l-serine were measured in eight common pure solvents and binary mixed solvents (acetonitrile + water, isopropanol + water, methanol + water, and acetone + water) from 278.15 to 333.15 K under atmospheric pressure by gravimetric method (acetone was measured from 278.15 to 328.15 K). The solubility of l-serine increases with increasing temperature, and the order in eight common pure solvents is water > acetonitrile > methanol > acetone > ethyl acetate > ethanol > n-butanol > isopropanol. In binary mixed solvents, the solubility of l-serine is dependent on temperature and solvent composition. Also, the solubility of l-serine increases with increasing temperature, and it decreases as the concentration of acetonitrile, isopropanol, methanol, or acetone increases at a constant temperature. The experimental data in eight pure solvents were fitted by the modified Apelblat model, Buchowski–Ksiazaczak λh model. The modified Apelblat equation, combined nearly ideal binary solvent/Redlich–Kister (CNIBS/R–K) model, and Jouyban–Acree model were used to correlate the experimental data in four binary solvents. Among the four models, the modified Apelblat model is more suitable with a higher accuracy than the other three models. The experimental data can be used to optimize the industrial manufacturing process of l-serine.

Determination and Analysis of Solubility of 4-[2-(N-Methylcarbamyl)-4-pyridyloxy]aniline in Ten Pure Solvents and Three Binary Solvent Mixtures at Different Temperatures (T = 278.15–323.15 K)

“…Then, the water tank was put on a magnetic stirrer. The temperature range was from 278.15 to 323.15 K with a 5 K gradient, the test was repeated 10 times, , and the temperature error of the whole system was below ±0.05 K. The magnetic stirrer was used to stir the solute and solvent for 24 h to fully dissolve the solute. Then, the magnetic stirrer was turned off and the solution was left to stand for 24 h to ensure that the excess solids in the system settled down so that the solid–liquid two phases reached equilibrium.…”

“…All molar quantities are based on the IUPAC relative atomic mass table. Because of the uncertainty of the weighing process, temperature change, water bath instability, and inaccurate determination of the amount of solute added, the experimental error does not exceed 2%. , …”