Thermodynamic and structural study of phenanthroline derivative ruthenium complex/DNA interactions: Probing partial intercalation and binding properties

Grueso, Elia; López-Pérez, G.; Castellano, Marı́a; Prado‐Gotor, Rafael

doi:10.1016/j.jinorgbio.2011.09.028

Cited by 82 publications

(32 citation statements)

References 61 publications

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“…in the cases of some 1,10-phenanthroline compounds. 33,34 Although two easily leaving chlorides in the structures of Na[RuCl 2 (N-R-5-X-salim) 2 ] do not exclude a priori covalent binding or even electrostatic interaction of neutral and positively charged complex species produced by loss of chlorides, our spectroscopic and electrochemical investigations suggest an intercalative mode of binding with constant of order 10 4 M −1…”

Section: Resultsmentioning

confidence: 81%

DNA Binding Properties of Two Ruthenium(III) Complexes Containing Schiff Bases Derived from Salicylaldehyde: Spectroscopic and Electrochemical Evidence of CT DNA Intercalation

et al. 2013

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Abstract. The interaction of CT DNA by two anionic Ru(III) complexes with N-substituted salicylidenimine ligands was investigated by spectroscopic titration and cyclic voltammetry. The result gives a surprising evidence for intercalation of DNA by the negatively charged complex species containing non typical intercalating ligands with K b of order 10 4 M −1 . Na[RuCl 2 (N-R-5-X-salim) 2 ], where R represents butyl or phenyl and X = H, Cl, were characterized on the basis of elemental analysis, MALDI-TOF mass spectrometry, infrared, UV / visible spectroscopic measurements and cyclic voltammetry. (doi: 10.5562/cca2216)

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Section: Resultsmentioning

confidence: 81%

DNA Binding Properties of Two Ruthenium(III) Complexes Containing Schiff Bases Derived from Salicylaldehyde: Spectroscopic and Electrochemical Evidence of CT DNA Intercalation

et al. 2013

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“…For these studies, Poly (dA À dT) and poly (dG À dC) sequences are commonly used. Groove binders are known to preferably bind to AT rich sequences as compared to GC rich sequences [30]. For example, binding of trans-4-[4-(dime thylamino)styryl]-1-methylpyridinium iodide (DSMI, a groove binding dye) to poly (dA À dT) sequence results in a greater enhancement in fluorescence yield as compared to poly (dG À dC) sequences [19].…”

Section: Ki Quenching Studiesmentioning

confidence: 99%

Studying non-covalent drug–DNA interactions

Rehman

Sarwar

Husain

et al. 2015

Archives of Biochemistry and Biophysics

295

160

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“…[40][41][42] As such, fluorescence spectroscopy was utilised in this study to investigate the interactions of complexes 1-16 with CT-DNA. Fluorescent intercalator displacement assays (FIDs) were used as neither the PCs or CT-DNA are intrinsically fluorescent.…”

Section: Dalton Transactions Papermentioning

confidence: 99%

Synthesis and analysis of the anticancer activity of platinum(ii) complexes incorporating dipyridoquinoxaline variants

Pages

Wormell

et al. 2014

Dalton Trans.

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Eight platinum(II) complexes with anticancer potential have been synthesised and characterised. These complexes are of the type [, where I L is either dipyrido[3,2-f:2',3'-h]quinoxaline (dpq) or 2,3-dimethyl-dpq (23Me 2 dpq) and A L is one of the R,R or S,S isomers of either 1,2-diaminocyclohexane (SS-dach or RR-dach) or 1,2-diaminocyclopentane (SS-dacp or RR-dacp). The CT-DNA binding of these complexes and a series of other complexes were assessed using fluorescent intercalator displacement assays, resulting in unexpected trends in DNA binding affinity. The cytotoxicity of the eight synthesised compounds was determined in the L1210 cell line; the most cytotoxic of these were [Pt(dpq)(SS-dach)]Cl 2 and [Pt(dpq)(RR-dach)]Cl 2 , with IC 50 values of 0.19 and 0.80 μM, respectively. The X-ray crystal structure of the complex [Pt(dpq)(SS-dach)](ClO 4 ) 2 ·1.75H 2 O is also reported.

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Thermodynamic and structural study of phenanthroline derivative ruthenium complex/DNA interactions: Probing partial intercalation and binding properties

Cited by 82 publications

References 61 publications

DNA Binding Properties of Two Ruthenium(III) Complexes Containing Schiff Bases Derived from Salicylaldehyde: Spectroscopic and Electrochemical Evidence of CT DNA Intercalation

DNA Binding Properties of Two Ruthenium(III) Complexes Containing Schiff Bases Derived from Salicylaldehyde: Spectroscopic and Electrochemical Evidence of CT DNA Intercalation

Studying non-covalent drug–DNA interactions

Synthesis and analysis of the anticancer activity of platinum(ii) complexes incorporating dipyridoquinoxaline variants

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