2012
DOI: 10.1016/j.jinorgbio.2011.09.028
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Thermodynamic and structural study of phenanthroline derivative ruthenium complex/DNA interactions: Probing partial intercalation and binding properties

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Cited by 83 publications
(32 citation statements)
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“…in the cases of some 1,10-phenanthroline compounds. 33,34 Although two easily leaving chlorides in the structures of Na[RuCl 2 (N-R-5-X-salim) 2 ] do not exclude a priori covalent binding or even electrostatic interaction of neutral and positively charged complex species produced by loss of chlorides, our spectroscopic and electrochemical investigations suggest an intercalative mode of binding with constant of order 10 4 M −1…”
Section: Resultsmentioning
confidence: 81%
“…in the cases of some 1,10-phenanthroline compounds. 33,34 Although two easily leaving chlorides in the structures of Na[RuCl 2 (N-R-5-X-salim) 2 ] do not exclude a priori covalent binding or even electrostatic interaction of neutral and positively charged complex species produced by loss of chlorides, our spectroscopic and electrochemical investigations suggest an intercalative mode of binding with constant of order 10 4 M −1…”
Section: Resultsmentioning
confidence: 81%
“…For these studies, Poly (dA À dT) and poly (dG À dC) sequences are commonly used. Groove binders are known to preferably bind to AT rich sequences as compared to GC rich sequences [30]. For example, binding of trans-4-[4-(dime thylamino)styryl]-1-methylpyridinium iodide (DSMI, a groove binding dye) to poly (dA À dT) sequence results in a greater enhancement in fluorescence yield as compared to poly (dG À dC) sequences [19].…”
Section: Ki Quenching Studiesmentioning
confidence: 99%
“…[40][41][42] As such, fluorescence spectroscopy was utilised in this study to investigate the interactions of complexes 1-16 with CT-DNA. Fluorescent intercalator displacement assays (FIDs) were used as neither the PCs or CT-DNA are intrinsically fluorescent.…”
Section: Dalton Transactions Papermentioning
confidence: 99%