DNA Binding Properties of Two Ruthenium(III) Complexes Containing Schiff Bases Derived from Salicylaldehyde: Spectroscopic and Electrochemical Evidence of CT DNA Intercalation

Ljubijankić, Nevzeta; Zahirović, Adnan; Turkušić, Emir; Kahrović, Emira

doi:10.5562/cca2216

Cited by 36 publications

(21 citation statements)

References 13 publications

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“…In the case of mononuclear Ru III complex species with similar coordination core, e.g. RuCl 2 N 2 O 2 and RuN 2 O 4 , corresponding half wave‐potentials have more negative values 11,12. The presence of O‐bridging atoms in [Ru 2 L 2 Cl 2 (Et 2 NH)(H 2 O)] · H 2 O stabilizes the complex toward oxidation compared to corresponding mononuclear species.…”

Section: Resultsmentioning

confidence: 99%

A Dinuclear Ruthenium(II) Schiff Base Complex with Dissimilar Coordination: Synthesis, Characterization, and Biological Activity

Kahrović

Zahirović

Turkušić

et al. 2016

Zeitschrift anorg allge chemie

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A dinuclear Schiff base RuII complex derived from 5‐chlorosalicylaldehyde and 2‐aminopyridine was synthesized. The structure of the compound was analyzed by mass spectrometry as well as IR, UV/Vis, and 1H NMR spectroscopy, along with chemical analysis,as well as magnetic, cyclovoltammetric and conductivity measurements. Two RuII atoms are octahedrally coordinated by azomethine and pyridine nitrogen atoms from two tridentate monobasic Schiff bases and bridging phenol oxygen atoms. The formula of the complex is [Ru2L2Cl2(Et2NH)(H2O)] [L = N‐(2‐pyridyl)‐5‐chlorosalicylideneimine and Et2NH = isodiethylamine]. The RuII atoms in the dinuclear neutral complex species have different coordination environments, RuN3O2Cl and RuN2O3Cl. Interaction with CT DNA showed moderate hydrophobic binding. The compound demonstrates strong activity against methicillin‐resistant Staphylococcus aureus, methicillin‐sensitive Staphylococcus aureus, and especially Enterococcus faecalis. Microbiological tests showed significant inhibition of growth and ability to kill pathogens, similar or even improved compared to reference antibiotics vancomycin.

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Section: Resultsmentioning

confidence: 99%

A Dinuclear Ruthenium(II) Schiff Base Complex with Dissimilar Coordination: Synthesis, Characterization, and Biological Activity

Kahrović

Zahirović

Turkušić

et al. 2016

Zeitschrift anorg allge chemie

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“…[30][31][32] The lower values of binding constants for complexes 2 and 3 may be explained by the positions of the dppb and dpqQX ligands related to each other, which can difficult the intercalation of the complexes to DNA, mainly through the dpqQX ligand. The close values of binding constants between these complexes suggest that the charge of complex 3 does not play important role regarding interaction of the complex with DNA.…”

Section: Dna Binding Studies By Uv-vis Titrationmentioning

confidence: 99%

Polypyridyl Ruthenium Complexes: Novel DNA-Intercalating Agents against Human Breast Tumor

Barolli¹,

Corrêa²,

Miranda³

et al. 2017

J. Braz. Chem. Soc.

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This paper describes a new series of four DNA-intercalating agents with promising anticancer activities, based on ruthenium(II) with the planar ligand dpqQX (dpqQX = dipyrido[3,2-a:2',3'-c] quinoxaline [2,3-b] quinoxaline). The complexes identified as trans-[RuCl(dppb = 1,4-bis(diphenylphosphine)butane and PPh 3 = triphenylphosphine) were characterized by 31 P{ 1 H} nuclear magnetic resonance (NMR) and infrared spectroscopies, cyclic voltammetry, molar conductance measurements, elemental analysis, mass spectrometry and X-ray diffraction analysis for complex ct-[RuCl 2 (PPh 3 ) 2 (dpqQX)]. Their in vitro cytotoxic activities against MDA-MB-213 and MCF-7 breast cancer cells were evaluated and compared with normal L-929 cells. Low drug concentration at which 50% of the cells are viable relative to the control (IC 50 ) values were obtained for all four complexes compared with a reference metallodrug, cisplatin. In addition, DNA affinity studies from titrations, as well as the images obtained by atomic force microscopy (AFM) involving pBR322 plasmid DNA, suggest interactions between the metal complexes and the DNA macromolecule, in which they act as intercalating agents. The intercalation of the complexes with DNA was confirmed by viscosity measurements.

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“…Schiff bases can be readily synthesized from the condensation reactions between the primary amine and carbonyl compounds . Ligands and metal complexes containing various substituent groups on the salicylidene rings are extensively studied . Because, these compounds and metal complexes have superior properties and are widely used in many areas.…”

Section: Introductionmentioning

confidence: 99%

“…[6] Ligands and metal complexes containing various substituent groups on the salicylidene rings are extensively studied. [7][8][9] Because, these compounds and metal complexes have superior properties and are widely used in many areas. In many earlier published studies, the substitution effects on the biological activities, [10] catalysis, [11] DNA binding, [12] electronic, [13] electrochemical [14] and thermal properties were investigated.…”

Section: Introductionmentioning

confidence: 99%

Structural characterization of disperse black 9 based Cu (II) complex and investigation of its some properties

Tümer¹,

Köse²,

Akar³

et al. 2019

Applied Organom Chemis

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We obtained the azo‐imine ligand (2,2′‐[4‐(5‐methoxy salicylidene‐4‐iminophenylazo)phenylimino]diethanol) (HL) and its Cu (II) complex (CuL) from the ethanol solution. The complex Cu(L)2 was obtained as single crystals from the CH3OH solution and structurally characterized. The electronic and photoluminescence properties of the ligand and its Cu (II) complex were investigated both in DMF solution and solid state. The oxidation and reduction behaviours of the compounds were studied in the solution and found that the redox processes are irreversible. Thermal studies show that the ligand has higher thermal stability than the CuL complex. Single crystals of the complex were obtained from slow evaporation of a DMF solution of the complex. Crystals of the complex showed a diffraction pattern; however, the structure of the complex was able to be solved.

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DNA Binding Properties of Two Ruthenium(III) Complexes Containing Schiff Bases Derived from Salicylaldehyde: Spectroscopic and Electrochemical Evidence of CT DNA Intercalation

Cited by 36 publications

References 13 publications

A Dinuclear Ruthenium(II) Schiff Base Complex with Dissimilar Coordination: Synthesis, Characterization, and Biological Activity

A Dinuclear Ruthenium(II) Schiff Base Complex with Dissimilar Coordination: Synthesis, Characterization, and Biological Activity

Polypyridyl Ruthenium Complexes: Novel DNA-Intercalating Agents against Human Breast Tumor

Structural characterization of disperse black 9 based Cu (II) complex and investigation of its some properties

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