Thermoanalytical investigation of olanzapine compatibility with excipients used in solid oral dosage forms

Peres-Filho, Marco Júnio; Gaeti, Marilisa Pedroso Nogueira; Oliveira, Stela Ramirez de; Marreto, Ricardo Neves; Lima, Eliana Martins

doi:10.1007/s10973-010-1245-3

Cited by 36 publications

(9 citation statements)

References 30 publications

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“…Preformulation Studies. The assessment of possible interactions between a drug and different excipients used in formulation usually precedes large scale development trials of solid dosage forms [36,37]. Physical and chemical interactions between excipients and active pharmaceutical ingredients (API) are common place [38] and necessitate the screening of novel excipients for possible incompatibilities.…”

Section: Pharmaceutical Values Of Grewia Polysaccharide Gummentioning

confidence: 99%

Pharmaceutical Properties and Applications of a Natural Polymer from Grewia mollis

Nep

Odumosu

Ngwuluka

et al. 2013

Journal of Polymers

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The use of naturally occurring biocompatible materials has been the focus of recent research activity in the design of dosage forms for immediate and controlled release formulations. Grewia gum is an intracellular gum obtained by extraction from the inner stem bark of the shrub Grewia mollis (Malvaceae). It grows abundantly (wild or cultivated) in the middle belt region of Nigeria, and the mucilage has been used by indigenes of this belt as thickener in soups. Grewia gum has been investigated for potential applications in pharmaceutical dosage forms. The industrial extrapolation of the applications of the gum has, however, been slowed by the limited structural, toxicological, and stability data available on the gum. This paper highlights ethnobotanical uses of G. mollis shrub and discusses the structural features, functional properties, and applications of grewia gum with emphases on its pharmaceutical potentials.

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Section: Pharmaceutical Values Of Grewia Polysaccharide Gummentioning

confidence: 99%

Pharmaceutical Properties and Applications of a Natural Polymer from Grewia mollis

Nep

Odumosu

Ngwuluka

et al. 2013

Journal of Polymers

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“…Several reports are described in the literature to evaluate the interactions between API and excipients using thermal and non-thermal techniques, for example Fourier transformed infrared spectroscopy (FTIR), HPLC, LC-MS/TOF and LC/UV applying mathematical and statistical models to correlate and analyze the results obtained [21][22][23][24][25][26][27][28][29][30].…”

Section: Introductionmentioning

confidence: 99%

Compatibility study between ferulic acid and excipients used in cosmetic formulations by TG/DTG, DSC and FTIR

Bezerra

Pereira

Ostrosky

et al. 2016

J Therm Anal Calorim

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Ferulic acid (4-hydroxy-3-methoxycinnamic acid) is a phytochemical constituent from the polyphenols group commonly found in whole grains, spinach, parsley, grapes and rhubarb. It has been widely applied in skin care formulations as photoprotective agent and delayer of cutaneous photoaging processes. This work aims to establish a protocol to the development of cosmetic formulations using thermoanalytical techniques (TG/DTG and DSC) and Pearson's correlation by FTIR data, in order to evaluate the compatibility between ferulic acid and excipients used in skin care formulations. The results obtained from the thermoanalytical techniques indicated compatibility between ferulic acid and the following excipients: passion fruit seed oil, Carbopol Ò Ultrez 30, EDTA, Crodabase CR2 Ò , Crodamol TM GTCC and Dow Corning Ò RM 2051. Nevertheless, the analysis also demonstrated the possibility of some interaction between ferulic acid and the following excipients: glyceryl stearate, Rapithix Ò A-60 and Optiphen Ò . To validate these results, it was demonstrated by Pearson's correlation that passion fruit seed oil, Carbopol Ò Ultrez 30, EDTA, Crodabase CR2 Ò , Crodamol TM GTCC, Dow Corning Ò RM 2051, glyceryl stearate and Rapithix Ò A-60 do not have any incompatibility that may compromise ferulic acid properties. Finally, it was also proved a meaningful incompatibility between ferulic acid and Optiphen Ò using Pearson's correlation. Thus, it is not recommended to use Optiphen Ò in the development of cosmetic formulations to carry ferulic acid.

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“…One such technique is thermal analysis, which forms the backbone of any preformulation exercise. Thermal methods like DSC have been extensively used for estimation of drug-excipient interaction [26][27][28][29] studies, purity estimation [30], polymorphic transition [31,32], polymer characterization etc [33]. However making use of DSC in estimating mixing uniformity in a blend is something which is not being explored so far.…”

Section: Introductionmentioning

confidence: 99%

Exploring mixing uniformity of a pharmaceutical blend in a high shear mixture granulator using enthalpy values obtained from DSC

2015

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Thermoanalytical investigation of olanzapine compatibility with excipients used in solid oral dosage forms

Cited by 36 publications

References 30 publications

Pharmaceutical Properties and Applications of a Natural Polymer from Grewia mollis

Pharmaceutical Properties and Applications of a Natural Polymer from Grewia mollis

Compatibility study between ferulic acid and excipients used in cosmetic formulations by TG/DTG, DSC and FTIR

Exploring mixing uniformity of a pharmaceutical blend in a high shear mixture granulator using enthalpy values obtained from DSC

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