Thermo-sensitive injectable hydrogel based on the physical mixing of hyaluronic acid and Pluronic F-127 for sustained NSAID delivery

Jung, Young-Seok; Park, Wooram; Park, Hyejin; Lee, Deok-Keun; Na, Kun

doi:10.1016/j.carbpol.2016.08.068

Cited by 201 publications

(103 citation statements)

References 26 publications

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“…The LDH hybrid thermo-sensitive hydrogel was formed by dispersing 0.1 g LDH into P407 solution (containing 2.0 g P407 and 8 ml ultrapure water) at 4 C under stirring [19,20]. For in vivo pharmacokinetics evaluation, Nile red was chosen as a hydrophobic drug model to be intercalated into LDH by dispersing LDH in Nile red methanol solution then dialysis against ultrapure water, after that theaflavin and P407 were dissolved in this drug loaded LDH dispersion with final concentration of P407 at 20% (wt%).…”

Section: Preparation Of Ldh Hybrid Thermo-sensitive Hydrogelmentioning

confidence: 99%

RETRACTED ARTICLE: LDH hybrid thermosensitive hydrogel for intravaginal delivery of anti-HIV drugs

Tian

Han

Huang

et al. 2019

Artificial Cells, Nanomedicine, and Biotechnology

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Microbicides based on hydrogel have become an effective way to prevent the HIV replication and transmission because of their convenience and prolonging drug release. In this study, a hybrid thermosensitive hydrogel constituted by nanosized layered double hydroxides and poloxamer 407 (P407) was constructed and co-loaded with both hydrophobic and hydrophilic drug. The LDH-P407 hydrogel could achieve sol-gel transition at body temperature. The in vivo experiment showed that LDH-P407 hydrogel can achieve controlled release of theaflavin and Nile red (hydrophobic drug model) into blood by vaginal drug delivery, meanwhile the hydrogel showed barely mucosal irritation. In addition, ex vivo experiment showed that the nifeviroc-loaded LDH-P407 hydrogel was able to specifically bind co-receptor CCR5 of DCs cells. Therefore, the LDH-P407 hydrogel would be a promising carrier for intravaginal delivery of anti-HIV drugs.

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Section: Preparation Of Ldh Hybrid Thermo-sensitive Hydrogelmentioning

confidence: 99%

RETRACTED ARTICLE: LDH hybrid thermosensitive hydrogel for intravaginal delivery of anti-HIV drugs

Tian

Han

Huang

et al. 2019

Artificial Cells, Nanomedicine, and Biotechnology

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“…However, local administration of drugs is unable to achieve long-term effect and topical hydrogels are not suitable for protein drugs. In recent years, injectable hydrogels have been widely investigated due to their properties of in situ sustained release of encapsulated drugs, improved stability and intensive adhesion for prolonged retention [4][5][6]. Among them, thermo-sensitive in situ gels, composed of cells, anti-inflammatory drugs and growth factors, which could be injected into inflammation sites as solutions and converted to gels rapidly inside the body, has become one of the most promising hydrogels for tissue engineering, especially in bone regeneration [7].…”

Section: Introductionmentioning

confidence: 99%

“…Among them, thermo-sensitive in situ gels, composed of cells, anti-inflammatory drugs and growth factors, which could be injected into inflammation sites as solutions and converted to gels rapidly inside the body, has become one of the most promising hydrogels for tissue engineering, especially in bone regeneration [7]. Pluronic F127, a FDA approved synthetic polymer of poly (propylene oxide) (PPO) blocks flanked by poly (ethylene oxide) (PEO) blocks, has been widely used in thermo-sensitive in situ gels [5,8]. The thermos-reversible property makes Pluronic F127 possible to convert its solution state to the gelation state when reaching the critical gelation temperature.…”

Section: Introductionmentioning

confidence: 99%

ECM based injectable thermo-sensitive hydrogel on the recovery of injured cartilage induced by osteoarthritis

Cao

Han

et al. 2018

Artificial Cells, Nanomedicine, and Biotechnology

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Intra-articular injection of anti-inflammatory drugs can be a promising strategy for recovery of injured articular cartilage. We prepared a series of injectable thermo-sensitive composite hydrogels, composed of Pluronic F127, glycosaminoglycan (GAG) and bone morphogenetic protein (BMP-2), which was designed to mimic extracellular matrix (ECM). The rheological properties and dissolution rate of composite hydrogels containing chondroitin sulfate or with different hyaluronic acid molecular mass (10k, 90k, 800k) were investigated. Meanwhile, bovine serum albumin (BSA) or FITC-BSA was chosen as model drug loaded into PF/GAG hydrogels to study their sustained release behavior in vitro. The results showed that hydrogels could maintain shapes for more than 16 days and the release rate of BSA in PF/GAG composite gels was much slower than in PF127 gels, due to the affinity between BSA and GAG. Furthermore, increasing the molecular weight of hyaluronic acid correspondingly increased hydrogel dissolution rate and BSA release in the hydrogels. Subsequently, MTT experiments were performed to investigate the toxicity of the hydrogels on mouse pre-osteoblast cell MC3T3-E1. In vivo anti-inflammation results showed that PF/GAG@BMP-2 composite hydrogels had the most efficient efficacy on recovery of injured cartilage, which is induced by osteoarthritis, compared to the control groups (PF127@BMP-2 or BMP-2 saline solution).

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“…The triblock copolymers of poly(ethylene oxide) (PEO or PEG) and poly(propylene oxide) (PPO), which are commercially available as Pluronic ® or Poloxamer, are another example of well-known thermo-sensitive polymers for biomedical applications [14,15]. For example, a Pluronic mixture was used as an easy handling and stable resident tissue adhesion barrier [16].…”

Section: Sodium Alginate and Cellulose Nanofibers Nanocompositementioning

confidence: 99%

Injectable Hydrogels: A Review of Injectability Mechanisms and Biomedical Applications

Mellati

Akhtari

2019

RMM

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Hydrogels have been used for biomedical applications in recent decades. They are a perfect candidate for regenerative medicine as they resemble the extracellular matrix of native tissues. In addition, their highly hydrated structure makes them a suitable choice for drug and other therapeutics delivery. Injectable hydrogels have increasingly gained attention due to their capability for homogeneous mixing with cells and therapeutic agents, minimally invasive administration, and perfect defect filling. In this review, we discuss various mechanisms which facilitate injectability of hydrogels, including in situ gelling liquids, injectable gels, and injectable particles. Then, we explore the biomedical applications of injectable hydrogels, including tissue engineering, therapeutic agent delivery, and medical devices.

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Thermo-sensitive injectable hydrogel based on the physical mixing of hyaluronic acid and Pluronic F-127 for sustained NSAID delivery

Cited by 201 publications

References 26 publications

RETRACTED ARTICLE: LDH hybrid thermosensitive hydrogel for intravaginal delivery of anti-HIV drugs

RETRACTED ARTICLE: LDH hybrid thermosensitive hydrogel for intravaginal delivery of anti-HIV drugs

ECM based injectable thermo-sensitive hydrogel on the recovery of injured cartilage induced by osteoarthritis

Injectable Hydrogels: A Review of Injectability Mechanisms and Biomedical Applications

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