2018
DOI: 10.1080/21691401.2018.1452752
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ECM based injectable thermo-sensitive hydrogel on the recovery of injured cartilage induced by osteoarthritis

Abstract: Intra-articular injection of anti-inflammatory drugs can be a promising strategy for recovery of injured articular cartilage. We prepared a series of injectable thermo-sensitive composite hydrogels, composed of Pluronic F127, glycosaminoglycan (GAG) and bone morphogenetic protein (BMP-2), which was designed to mimic extracellular matrix (ECM). The rheological properties and dissolution rate of composite hydrogels containing chondroitin sulfate or with different hyaluronic acid molecular mass (10k, 90k, 800k) w… Show more

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Cited by 47 publications
(34 citation statements)
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“…The interaction of ECM components forms network structure, which provides nutrition for chondrocyte, and affects various biological functions of chondrocyte through signal transduction system. When OA occurs, the synthesis and degradation of ECM are unbalanced [14,15]. Many microRNAs (miRNAs) are tissue-specific or developmental stage-specific and are associated with diseases such as tumors, lymphomas, viral infections and orthopedic diseases [16].…”
Section: Introductionmentioning
confidence: 99%
“…The interaction of ECM components forms network structure, which provides nutrition for chondrocyte, and affects various biological functions of chondrocyte through signal transduction system. When OA occurs, the synthesis and degradation of ECM are unbalanced [14,15]. Many microRNAs (miRNAs) are tissue-specific or developmental stage-specific and are associated with diseases such as tumors, lymphomas, viral infections and orthopedic diseases [16].…”
Section: Introductionmentioning
confidence: 99%
“…Several biomaterials have been employed for developing injectable hydrogels to mimic the biological cues of native ECM, however, they cannot reproduce the complex functions of natural ECM. Recently, increasing attention has been paid to the development of tissue‐derived ECM as a biomaterial to generate injectable hydrogels, some of them based on dermal ECM or in hybrid injectable hydrogels of thermosensitive soluble ECM and methylcellulose as stem cell delivery systems in skin wound treatments …”
Section: Therapeutic Strategies For Skin Regenerationmentioning
confidence: 99%
“…Drug delivery systems provide an opportunity to incorporate therapeutics into a material that can provide sustained release into the joint [24]. A number of drug delivery systems for intra-articular injection have been developed, including liposomes [25], particles [26][27][28], hydrogels [29][30][31], and dendrimers [32]. Particles in particular have been shown to afford prolonged release in the joint over a period of months.…”
Section: Introductionmentioning
confidence: 99%