Thermo-sensitive gels containing lorazepam microspheres for intranasal brain targeting

Jose, Sajan; Ansa, C.R.; Cinu, T.A.; Chacko, A.J.; Aleykutty, NA; Ferreira, S.V.; Souto, Eliana B.

doi:10.1016/j.ijpharm.2012.10.049

Cited by 46 publications

(22 citation statements)

References 15 publications

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“…As reported earlier, chitosan microspheres were formed with low concentrations of chitosan in acetic acid [23]. Chitosan and glutaraldehyde concentrations, and the types of oil and chitosan have significant effects on cis-platin entrapment in chitosan microspheres.…”

Section: Introductionmentioning

confidence: 82%

Preparation and drug release properties of norisoboldine-loaded chitosan microspheres

Wang

Dou

et al. 2016

International Journal of Biological Macromolecules

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Section: Introductionmentioning

confidence: 82%

Preparation and drug release properties of norisoboldine-loaded chitosan microspheres

Wang

Dou

et al. 2016

International Journal of Biological Macromolecules

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“…The formulation loaded into upper donor compartment is separated from the receptor medium present in the lower compartment by a semipermeable membrane. Franz-diffusion cell was used to assess the drug release properties from numerous formulations aimed for nasal application, such as thermoresponsive soluble gels [55], ion activated in situ gels [56], microparticles [57], nanostructured lipid carriers [58], gel containing microspheres [59], lipidic emulsomes [60], in situ gelling microemulsions [61] and solid lipid nanoparticles [62]. This method is advantageous over other compendial and non-compendial membrane diffusion methods particularly in case of dry powders as it allows them to hydrate slowly, and gel eventually, in humid environment conditions designed to be similar to those encountered in the nasal cavity [63].…”

Section: Membrane Diffusion Methodsmentioning

confidence: 99%

In vitro dissolution/release methods for mucosal delivery systems

et al. 2017

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“…Final pH of the preparation was adjusted to 4.5 with 0.5 M sodium hydroxide solution. The gel was then further modified by the addition of varying proportion of HPMC K4M [13]. The composition of all the formulation is given in Table 2.…”

Section: Formulation Of the Mucoadhesive Microsphere-loaded Nasal Gelmentioning

confidence: 99%

“…The variation in pΗ was attributed to the concentration of Carbopol and HPMCK4M in the formulation. Jose et al, (2013) suggested the pH of the nasal gel formulations to be 5.23-6.08 [13].…”

Section: Characterization Of Gel-containing Microspheresmentioning

confidence: 99%

Development and Characterization of Mucoadhesive Microsphere-Loaded Intranasal Gel of Venlafaxine Hydrochloride

Saikia¹,

Kalita²,

Kalita³

2016

Asian J Pharm Clin Res

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Objective: The main objective of the present work is to develop and characterize a novel mucoadhesive intranasal microsphere gel formulation of drug venlafaxine to control the drug release through nasal mucosa and reach the target site with minimal side effect. The objectives of the study are (1) formulation of mucoadhesive microspheres, (2) evaluation of mucoadhesive microspheres, (3) formulation of mucoadhesive microsphereloaded nasal gel, (4) and evaluation of nasal gel.Methods: Preparation of chitosan microsphere: The chitosan microspheres were prepared by emulsion cross-linking method. Preparation of microsphere-loaded gel: The nasal gels with varying concentrations of Carbopol 934P were prepared by dispersing required quantity of Carbopol in required quantity of distilled water with continuous stirring and kept overnight for complete hydration. The gel was then modified by the addition of varying proportion of hydroxypropyl methylcellulose (HPMC) K4M. Results:The prepared microspheres were evaluated for size distribution, surface morphology by scanning electron microscopy, entrapment efficiency, compatibility by Fourier transform infrared spectroscopy, and differential scanning calorimetry. Entrapment efficiency of all formulations was found more than 70%. Microsphere formulation containing drug and polymer in the ratio of 1:2.5 was found to be optimized. Optimized microsphere formulation was then incorporated in gel prepared using Carbopol 934P and HPMC. Prepared gel formulations were studied for viscosity, spreadability, and in-vitro drug release in simulated nasal conditions. Viscosity of the optimized batch of gel was recorded at 1056 centipoise. Drug release was prolonged for the microsphere-in-gel formulations compared to the microspheres alone. For the optimized batch of gel, cumulative drug release of 85.67% was found after 8 hrs. Conclusion:The results suggest that venlafaxine hydrochloride mucoadhesive microsphere-loaded nasal gel would give sustained drug release and superior bioavailability in the brain sites.

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Thermo-sensitive gels containing lorazepam microspheres for intranasal brain targeting

Cited by 46 publications

References 15 publications

Preparation and drug release properties of norisoboldine-loaded chitosan microspheres

Preparation and drug release properties of norisoboldine-loaded chitosan microspheres

In vitro dissolution/release methods for mucosal delivery systems

Development and Characterization of Mucoadhesive Microsphere-Loaded Intranasal Gel of Venlafaxine Hydrochloride

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