Thermo-responsive wound dressings by grafting chitosan and poly(N-isopropylacrylamide) to plasma-induced graft polymerization modified non-woven fabrics

Chen, Jyh‐Ping; Kuo, Chang-Yi; Lee, Wen-Li

doi:10.1016/j.apsusc.2012.02.106

Cited by 73 publications

(32 citation statements)

References 22 publications

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“…From histological images of the newborn skin tissues at the wound site confirms that no infection and inflammation were observed in wound site covered with PP-g-CS-g-PNIPAAm NWF throughout the wound healing process. Hence it confirms that the PPg-CS-gPNIPAAm is useful and potential wound dressing material [113].…”

Section: Wound Dressings With Chitosan and Synthetic Polymersmentioning

confidence: 73%

Chitosan: A Potential Therapeutic Dressing Material for Wound Healing

Archana

Dutta

2015

Springer Series on Polymer and Composite Materials

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A wide variety of polymers have been used over decades for the preparation of dressing materials for wound healing applications. But the dressing materials based on polysaccharides such as chitosan (CS) have received tremendous attention of the worldwide researchers as a consequence of its important properties like anti-infectional activity, biocompatibility, biodegradability, nontoxicity to mention a few. CS helps in every phase of wound healing such as acting as barrier against microbes, absorbing exudates, accelerates the infiltration of inflammatory cells like neutrophils and helps in healing without scar formation. A reason behind the popularity of CS is that not only it can easily be processed as gels, films, fibers, and scaffolds but also can be blended with natural as well as synthetic polymers to reduce price and improve properties like mechanical, wettability, gas permeability, and handling. Apart from natural and synthetic polymers, CS is also blended with nanoparticles and growth factors to which it shows better antibacterial activity and reduce time span for wound healing. The present chapter aims to focus on feasibility of combining natural polymers, synthetic polymers, nanoparticles, and growth factors with CS for the preparation of wound dressings as basic healthcare materials for regenerative medicine.

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Section: Wound Dressings With Chitosan and Synthetic Polymersmentioning

confidence: 73%

Chitosan: A Potential Therapeutic Dressing Material for Wound Healing

Archana

Dutta

2015

Springer Series on Polymer and Composite Materials

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“…By controlling the input power, 161 pulsing frequency and the duration of the pulse it is possible to tune chemical functionality, surface morphology and density of desired chemical functionality at the polymer surface. 162,163 The process is highly versatile in terms of resultant surface chemistry, with pyridine, 158 anhydride, 164 amine, 165 ester, 166 hydroxyl, [167][168][169] sulfonic acid, 170 carboxylic acid, 171 cyano, 172, 173 epoxide, 174 halide, 175 thiol, 137,176 and furan 177 functionalised surfaces reported.…”

Section: Pulsed Plasma Depositionmentioning

confidence: 99%

Anti-bacterial surfaces: natural agents, mechanisms of action, and plasma surface modification

et al. 2015

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REVIEW This journal isStrategies that confine antibacterial and/or antifouling property to the surface of the implant, by modifying the surface chemistry and morphology or by encapsulating the material in an antibiotic-loaded coating, are most promising as they do not alter bulk integrity of the material. Among them, plasma-assisted modification and catechol chemistry stand out for their ability to modify a wide range of substrates. By controlling processing parameters, plasma environment can be used for surface nano structuring, chemical activation, and deposition of biologically active and passive coatings. Catechol chemistry can be used for material-independent, highlycontrolled surface immobilisation of active molecules and fabrication of biodegradable drugloaded hydrogel coatings. In this article, we comprehensively review the role plasma-assisted processing and catechol chemistry can play in combating bacterial colonisation on medically relevant coatings, and how these strategies can be coupled with the use of natural antimicrobial agents to produce synthetic antibiotic-free antibacterial surfaces.

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“…The wound-healing test results showed a decrease in wound area to 5% in 17 days for bi-grafted polypropylene fabrics as compared to conventional gauze. Similarly, Chen et al (2012) have modified polypropylene non-woven fabric using DC-pulsed oxygen plasma-induced graft polymerization of acrylic acid to improve hydrophilicity. Chitosan was grafted on to the polymerized surface and subsequently grafted with poly (N-isopropylacrylamide) chemically to obtain temperature responsive and easy strip-off characteristics from the wound.…”

Section: Functionalization With Moleculesmentioning

confidence: 99%

Plasma treatments of dressings for wound healing: a review

Eswaramoorthy

McKenzie

2017

Biophys Rev

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This review covers the use of plasma technology relevant to the preparation of dressings for wound healing. The current state of knowledge of plasma treatments that have potential to provide enhanced functional surfaces for rapid and effective healing is summarized. Dressings that are specialized to the needs of individual cases of chronic wounds such as diabetic ulcers are a special focus. A summary of the biology of wound healing and a discussion of the various types of plasmas that are suitable for the customizing of wound dressings are given. Plasma treatment allows the surface energy and air permeability of the dressing to be controlled, to ensure optimum interaction with the wound. Plasmas also provide control over the surface chemistry and in cases where the plasma creates energetic ion bombardment, activation with long-lived radicals that can bind therapeutic molecules covalently to the surface of the dressing. Therapeutic innovations enabled by plasma treatment include the attachment of microRNA or antimicrobial peptides. Bioactive molecules that promote subsequent cell adhesion and proliferation can also be bound, leading to the recruitment of cells to the dressing that may be stem cells or patient-derived cells. The presence of a communicating cell population expressing factors promotes healing.

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Thermo-responsive wound dressings by grafting chitosan and poly(N-isopropylacrylamide) to plasma-induced graft polymerization modified non-woven fabrics

Cited by 73 publications

References 22 publications

Chitosan: A Potential Therapeutic Dressing Material for Wound Healing

Chitosan: A Potential Therapeutic Dressing Material for Wound Healing

Anti-bacterial surfaces: natural agents, mechanisms of action, and plasma surface modification

Plasma treatments of dressings for wound healing: a review

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