Thermo-responsive PNIPAAm-b-PLA amphiphilic block copolymer micelle as nanoplatform for docetaxel drug release

Ghasemi, Soheila; Ahmadi, Leila; Farjadian, Fatemeh

doi:10.1007/s10853-022-07711-w

Cited by 13 publications

(9 citation statements)

References 47 publications

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“…pNIPAAm is reported to experience a reversible phase shift in an aqueous medium [ 107 ]. For example, to be used in the structure of the drug carrier platform, a thermoresponsive PNIPAAm-b-PLA amphiphilic block copolymer micelle was synthesized by Ghasemi et al [ 124 ]. The temperature-sensitive polymeric micelle-loaded DTX underwent a temperature-prompted phase shift as a result of heating near its LCST in the as-prepared state.…”

Section: Polymeric Micellar Systems With “Smart” Responsivenessmentioning

confidence: 99%

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Polymeric Micellar Systems—A Special Emphasis on “Smart” Drug Delivery

Neguț

Biţă

2023

Pharmaceutics

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Concurrent developments in anticancer nanotechnological treatments have been observed as the burden of cancer increases every year. The 21st century has seen a transformation in the study of medicine thanks to the advancement in the field of material science and nanomedicine. Improved drug delivery systems with proven efficacy and fewer side effects have been made possible. Nanoformulations with varied functions are being created using lipids, polymers, and inorganic and peptide-based nanomedicines. Therefore, thorough knowledge of these intelligent nanomedicines is crucial for developing very promising drug delivery systems. Polymeric micelles are often simple to make and have high solubilization characteristics; as a result, they seem to be a promising alternative to other nanosystems. Even though recent studies have provided an overview of polymeric micelles, here we included a discussion on the “intelligent” drug delivery from these systems. We also summarized the state-of-the-art and the most recent developments of polymeric micellar systems with respect to cancer treatments. Additionally, we gave significant attention to the clinical translation potential of polymeric micellar systems in the treatment of various cancers.

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Section: Polymeric Micellar Systems With “Smart” Responsivenessmentioning

confidence: 99%

“…The DTX delivery at 40 °C was made by means of the carrier’s thermo-responsiveness property. As a result, PNIPAAm-b-PLA loaded DTX exhibits significant promise as a highly effective anti-cancer agent [ 124 ].…”

Section: Polymeric Micellar Systems With “Smart” Responsivenessmentioning

confidence: 99%

Polymeric Micellar Systems—A Special Emphasis on “Smart” Drug Delivery

Neguț

Biţă

2023

Pharmaceutics

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“…CS-g-pN nanogel formulations exhibited reasonable encapsulation rates and biocompatibility qualities and were not toxic to normal cells. In another study, Ghasemi et al [ 108 ] prepared thermally responsive PNIPAAm-b-poly(dodecyl acrylate) (PLA) NPs. The hydrophobic internal region was loaded with DTX at a high loading rate.…”

Section: Single Stimulus-responsive Polymer Nanocarriersmentioning

confidence: 99%

Research Progress on Stimulus-Responsive Polymer Nanocarriers for Cancer Treatment

Luo

Yang

et al. 2023

Pharmaceutics

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As drug carriers for cancer treatment, stimulus-responsive polymer nanomaterials are a major research focus. These nanocarriers respond to specific stimulus signals (e.g., pH, redox, hypoxia, enzymes, temperature, and light) to precisely control drug release, thereby improving drug uptake rates in cancer cells and reducing drug damage to normal cells. Therefore, we reviewed the research progress in the past 6 years and the mechanisms underpinning single and multiple stimulus-responsive polymer nanocarriers in tumour therapy. The advantages and disadvantages of various stimulus-responsive polymeric nanomaterials are summarised, and the future outlook is provided to provide a scientific and theoretical rationale for further research, development, and utilisation of stimulus-responsive nanocarriers.

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“…Not only is PLA bioderived, it is also biocompatible and can be used as a drug delivery support with various therapeutic agents, such as simvastatin for bone regeneration, 20 chemotherapy drugs 21, 22 and antibiotics 23, 24 . Interestingly, PLA is completely absorbed by the body and the rate of this depends on the molar mass and the stereo‐structure of the polymer chains 25 …”

Section: Poly(lactic Acid) and Poly(lactide)mentioning

confidence: 99%

Review: Syntheses of poly(lactic acid)s and their block copolymers for drug delivery applications

Oktavia

Bégué

Campana

et al. 2023

Polymer International

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Since the advent of supporting matrices for biological applications, many types of drugs have been administered via various forms of conventional drug delivery preparations, such as pills, solutions, creams, suppositories, injected gels and so on. Key parameters to all these systems for effective drug delivery are controlled release for sustained periods, targeted delivery, and enhancements of drug stability and efficacy, all of which can be manipulated by using polymers. Given the important impact of the structures of the polymers on these parameters, this mini‐review gives a simple introduction to the requirements of drug delivery systems and surveys the synthetic pathways to a key polymer in this field, namely poly(lactic acid). We also review the preparation of block copolymers that incorporate poly(lactic acid), to expand and further develop its properties for drug delivery systems. It is hoped that this short teacherly and introductory review will provide a basic stepping‐stone to more in‐depth reviews and papers and enable an easy access to this fast growing field. © 2023 Society of Industrial Chemistry.

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Thermo-responsive PNIPAAm-b-PLA amphiphilic block copolymer micelle as nanoplatform for docetaxel drug release

Cited by 13 publications

References 47 publications

Polymeric Micellar Systems—A Special Emphasis on “Smart” Drug Delivery

Polymeric Micellar Systems—A Special Emphasis on “Smart” Drug Delivery

Research Progress on Stimulus-Responsive Polymer Nanocarriers for Cancer Treatment

Review: Syntheses of poly(lactic acid)s and their block copolymers for drug delivery applications

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