Thermo- and Light-Responsive Polymer-Coated Magnetic Nanoparticles as Potential Drug Carriers

Abstract

A series of thermo- and light-responsive copolymers of poly (N-isopropylacrylamide) (PNIPAM) and 6-[4-(4-methoxy phenyl azo)-phenoxyl-hexyl methacrylate) (AzoMA) (PNIPAM-b-PAzoMA) were synthesized via reversible addition–fragmentation chain transfer (RAFT) radical polymerization. The resulting copolymers had a narrow molecular weight distribution range of 1.06–1.24, in which Mn changed regularly with the monomer concentration. Subsequently, the diblock copolymers were successfully modified on the surface of iron oxide nanoparticles through the interaction between the chemical bonds to prepare Fe3O4@(PNIPAM-b-PAzoMA) nanoparticles. The size of fabricated nanoparticles with excellent thermo-sensitivity and photo-sensitivity was controlled at about 40–50 nm. Cell viability assays suggested that the nanoparticles showed no significant cytotoxicity and potential drug delivery in the tumor microenvironment.

Controllable Regulation of Diesel Oil-in-Water Pickering Emulsion Stability by Multiresponsive Recyclable Magnetic Polymer Brush Microvessels

“…The RAFT chain transfer agent BCSPA was prepared according to the previously reported method . The magnetic chain transfer agent was obtained by grafting the chain transfer agent BCSPA on the surface of Fe 3 O 4 @PDA via esterification reaction . First, Fe 3 O 4 @PDA (0.2 g) and chain transfer agent BCSPA (0.2 g) were added to 50 mL of DMF and dispersed under sonication for 15 min.…”

Nanomedicines Based on Responsive Nanocarriers for Cancer Therapy

“…It had good photosensitivity, thermal stability, temperature sensitivity, and superparamagnetism, which could achieve drug delivery in the TME for anti-tumor therapy. [97] PTT is an effective means to treat melanoma. Some studies have shown that the polymer hydrogel formed by the co-assembly of reduced graphene oxide functionalized DOX, porcine small intestinal submucosa methacrylate (SISMA), and chitosan methacrylate (ChiMA) had the ability to release drug DOX in both light and thermo response.…”

“…It had good photosensitivity, thermal stability, temperature sensitivity, and superparamagnetism, which could achieve drug delivery in the TME for anti‐tumor therapy. [ 97 ]…”

Thermosensitive Behavior Defines the Features of Poly(N-isopropylacrylamide)/Magnetite Nanoparticles for Cancer Management

“…The lower critical solution temperature (LCST) of 32-34 • C for this "smart polymer" has made it useful for various applications such as valves and sensors, cell culture media, membranes, and drug delivery systems [35][36][37][38]. Numerous PNIPAM nanocarrier systems have been developed as candidates for use in biomedical applications [39][40][41][42][43]. The combined assembly of stimuli-responsive polymers with inorganic magnetic nanoparticles could exhibit properties for controlled delivery of doxorubicin into biological targets.…”