Nanomedicines Based on Responsive Nanocarriers for Cancer Therapy

Abstract

Nanotechnology has been widely used in drug design in recent years, showing great potential and advantages in tumor therapy. However, the application of most traditional nanomedicines is still limited by low drug loading rate, poor targeting ability, and systemic toxicity. Based on the characteristics of tumor microenvironments, numerous studies indicate that the construction of stimuli‐responsive nanocarriers can effectively solve the above problems by improving delivery efficiency, reducing side effects, and enhancing targeting. A significant feature of responsive nanocarriers is that they can release and activate drugs at specific sites under stimulus, including internal stimuli (e.g., pH, reactive oxygen species (ROS), glutathione (GSH), enzyme, hypoxia, adenosine‐triphosphate (ATP), etc.) and external stimuli (e.g., light, thermo, ultrasound, etc.). Of note, learning about various pathways of responses can enable researchers to effectively design responsive nanocarriers for tumor therapy. Herein, this review focuses on the stimuli‐responsive strategies of nanocarriers for tumor therapy. In addition, the role of responsive nanocarriers in synergistic tumor therapy is also discussed. The expectation of this review is to provide ideas for the design of practical and effective responsive nanocarriers.

Autocatalytic Artesunate Coordinated ZIF-8 Nanoplatforms with Metal-Polyphenol Network Coating for Targeted Tumor Chemodynamic Therapy

“…Recently, metal–organic framework (MOF) is an emerging porous coordination framework material formed by the coordination of metal ions or metal clusters with organic ligands. − Compared with the traditional drug delivery system, MOF has broad application prospects in drug delivery due to its advantages of high porosity, large specific surface area and easy modification. − Interestingly, the coordination between bivalent metal ions and organic ligands is reversible, which can be broken under low pH condition to achieve intelligent drug release. − As a typical MOF, zeolite imidazole framework-8 (ZIF-8) is formed by the coordination of Zn 2+ with the N atom on the 2-methylimidazole (2-MIM). − Zn 2+ is essential for human body and 2-MIM is involved in histidine metabolism . These advantages endow ZIF-8 with versatile biomedical applications as an ideal drug carrier.…”