Thermische Ablation von Lebermetastasen: Aktueller Stand und Perspektiven

Vogl, Thomas J.; Mack, Martin G.; Straub, Roland; Zangos, Stephan; Woitaschek, Dirk; Eichler, K.; Engelmann, K.

doi:10.1007/s001170050926

Cited by 31 publications

(10 citation statements)

References 16 publications

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“…However, some patients are not amenable for surgery because of medical impairment or disadvantageous localization of the tumor as bilobar metastases in the lung or liver. In this situation the local control rates of extracranial stereotactic radiotherapy have to compete with other treatment modalities such as laser induced thermotherapy (LITT) [19], radiofrequence ablation (RFA) [15] or percutaneous ethanol instillation (PEI) [17], which are available for the treatment of hepatocellular carcinoma and liver metastases. While for radiofrequence ablation local control rates for liver metastases of 70% [15], for percutaneous ethanol instillation up to 86% [17] are reported, for laser induced thermotherapy local control rates of up to 98% have been achieved by experienced authors [19].…”

Section: Discussionmentioning

confidence: 99%

“…In this situation the local control rates of extracranial stereotactic radiotherapy have to compete with other treatment modalities such as laser induced thermotherapy (LITT) [19], radiofrequence ablation (RFA) [15] or percutaneous ethanol instillation (PEI) [17], which are available for the treatment of hepatocellular carcinoma and liver metastases. While for radiofrequence ablation local control rates for liver metastases of 70% [15], for percutaneous ethanol instillation up to 86% [17] are reported, for laser induced thermotherapy local control rates of up to 98% have been achieved by experienced authors [19]. Not only under the assumption that patient and target selection have some impact on the published results, the local control rates for extracranial stereotactic irradiation of 80-100% are at least similar to the local control rates reported of other modalities.…”

Section: Discussionmentioning

confidence: 99%

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Stereotactic Radiotherapy of Targets in the Lung and Liver

Wulf¹,

Hädinger²,

Oppitz³

et al. 2001

Strahlenther Onkol

281

130

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Stereotactic Radiotherapy of Targets in the Lung and Liver

Wulf¹,

Hädinger²,

Oppitz³

et al. 2001

Strahlenther Onkol

281

130

View full text Add to dashboard Cite

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“…Sie nutzt dabei aber Absorptions-sowie ebenfalls Wärmekonvektionsvorgänge im Gewebe, welche zur Denaturierung von Proteinen und somit Koagulation führen. Verwendung finden vor allem Laser des nahen Infrarot-Bereiches aufgrund der vergleichsweise großen Eindringtiefe der Photonen und deren problemloser Strahlungsübertragung mittels Lichtleiter [12]. Durch Verän-derungen der Applikatorgeometrie mit diffuser Abstrahlung ist eine gleichmäßigere Verteilung der Laserenergie erreicht worden.…”

Section: Laserinduzierte Thermotherapieunclassified

Interventionelle Therapie von Lebermetastasen

Birth¹,

Hildebrand²,

Kleemann³

et al. 2003

Visc Med

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Interventional Therapy of Liver Metastases If non-resectable liver metastases remain untreated, the median survival only comes to a few months. While searching for alternative therapies, a number of procedures, which cause devitalization of metastases by different modes of action, has been invented. Among these procedures count thermal radiofrequency ablation (RFA), laser-induced thermotherapy, cryoablation, transarterial chemoembolization, focused ultrasound, microwave ablation, intratumoral injection of cytotoxic substances and electrolysis. In the meantime, numerous methods have left the experimental stage and are clinically evaluated at present. However, existing data are offen still poor. Thermal radiofrequency ablation is favored by many users because of its results, its easy handling, different modes of application and consecutive individual optimal usage as well as its cost efficiency in spite of apparent comparable effectiveness to other interventional procedures. Before their oncological role is evaluated with certainty, all procedures should be limited to palliative situations, i.e. to the treatment of patients, who are not suitable for surgical resection. In the future, prospective studies must evaluate the role of RFA and other procedures in the treatment of liver metastases.

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“…B. der Magnetresonanztomographie online überwacht. In einer prospektiven,nichtrandomisierten Studie wurde bei 364 Patienten mit Lebermetastasen kolorektaler Karzinome eine mittlere Überlebenszeit von 42,7 Monaten berichtet [81]. Klinisch relevante Komplikationen traten in 1,2% der Behandlungen auf.…”

Section: Laserinduzierte Thermotherapie (Litt)unclassified

Multimodale Therapiekonzepte beim Kolonkarzinom

2003

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In den letzten Jahren konnte durch die Einführung neuer Chemotherapeutika aus der Gruppe der Topoisomerasinhibitoren und der Platinderivate in die Therapie metastasierter kolorektaler Karzinome eine wesentliche Verbesserung der Überlebenszeit von Patienten erzielt werden.Ob diese Substanzen auch eine Verbesserung der Heilungsaussicht in der adjuvanten Therapie von Kolonkarzinomen darstellen, ist augenblicklich Gegenstand intensiver Untersuchungen. Darüber hinaus wurden zahlreiche oral verfügbare Chemotherapeutika entwickelt, die in ihrer Wertigkeit wahrscheinlich dem bisher intravenös eingesetzten 5-Fluoruracil entsprechen. Schließlich werden zunehmend Kombinationen von konventioneller Chemotherapie mit sog."Biologicals" wie Inhibitoren von Rezeptortyrosinkinasen, die für das Tumorwachstum eine entscheidende Rolle spielen, untersucht.Einen zunehmenden Stellenwert nehmen ferner die chirurgische Therapie von Metastasen, aber auch lokal ablative Verfahren wie die Radiofrequenzablation ein.Die vorliegende Arbeit fasst die aktuellen Daten zu den einzelnen Behandlungsverfahren zusammen und bewertet ihren Stellenwert in einem multimodalen Ansatz zur Therapie des Kolonkarzinoms. SchlüsselwörterKolonkarzinom · Chemotherapie · Metastasenchirurgie · Radiofrequenzablation · Kryotherapie

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Thermische Ablation von Lebermetastasen: Aktueller Stand und Perspektiven

Cited by 31 publications

References 16 publications

Stereotactic Radiotherapy of Targets in the Lung and Liver

Stereotactic Radiotherapy of Targets in the Lung and Liver

Interventionelle Therapie von Lebermetastasen

Multimodale Therapiekonzepte beim Kolonkarzinom

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