Thermal Unfolding, Proteins

Stabilization of human papillomavirus virus-like particles by non-ionic surfactants

“…38 This value is comparable to the free energy of 2-20 kcal/mol required to unfold the overall conformation or local structures of a globular protein. [42][43][44] Partial unfolding of protein molecules often results in protein aggregation. The HPV VLP aggregation was not observed in solutions with high HPV VLP concentration ($500 mcg/mL) and high salt concentrations (curve a in Figure 1).…”