Thermal modulation of intracellular drug distribution using thermoresponsive polymeric micelles

Thermo-responsive drug release from self-assembled micelles of brush-like PLA/PEG analogues block copolymers

“…The CMC was close to that of P (NIPAAm-co-DMAAm)-b-PLLA-b-P(NIPAAm-co-DMAAm) micelles (0.0113-0.0144). The very low CMC demonstrates the strong tendency of copolymers toward formation of micelles, which is of major importance for the stability of micelles in long circulation in the bloodstream after injection induced dilution (Nakayama et al, 2007).…”

Negative Impact of Paclitaxel Crystallization on Hydrogels and Novel Approaches for Anticancer Drug Delivery Systems

“…As a result, drug activity continues after a single application over a long period of time. In addition, these micelles remain intact at levels below the critical micelle concentration (CMC), so they retain their structure and preferentially accumulate in solid tumors via the permeability and retention effect (EPR) (Nakayama et al, 2007;Saez et al, 2004). Its amphiphilic nature gives them a central place in the area of the release of hydrophobic drugs, due to its excellent drug storage capacity in its core.…”

Cell Attachment–Detachment Control on Temperature-Responsive Thin Surfaces for Novel Tissue Engineering

“…Such a conformational change in response to temperature has been extensively used to modulate physicochemical properties of polymeric materials. 30,46,47,74 At 37°C, PIPAAm-grafted surface is slightly hydrophobic, allowing cells to proliferate under normal conditions. A decrease in temperature below 32°C, however, results in the rapid hydration of the polymer surface, leading to the spontaneous detachment of the cells as a single cell and/or a uniform tissue sheets.…”