Thermal cum lipopolysaccharide-induced stress challenge downregulates functional response of bovine monocyte-derived macrophages

Kandasamy, Rajamanickam; Leela, V.; Suganya, G.; Basha, Sabiha Hayath; Parthiban, M.; Pasuvalingam, Visha; Ayyasamy, Elango

doi:10.1016/j.jtherbio.2022.103301

Cited by 3 publications

(3 citation statements)

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“…A dramatic increase in TLR4 was reported in pathogen-induced inflammatory processes related to milk production [57]. Conversely, downregulation of TLR4 cell signaling has been detected in heat-stressed dairy cows, making them more susceptible to disease [58]. Such a decrease in TLR4 induced by thermal heat was also associated with a significant reduction in lipolytic activity and lipid milk content [59].…”

Section: Discussionmentioning

confidence: 99%

Genetic Markers Associated with Milk Production and Thermotolerance in Holstein Dairy Cows Managed in a Heat-Stressed Environment

Zamorano‐Algandar

Medrano

Thomas³

et al. 2023

Biology

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Dairy production in Holstein cows in a semiarid environment is challenging due to heat stress. Under such conditions, genetic selection for heat tolerance appears to be a useful strategy. The objective was to validate molecular markers associated with milk production and thermotolerance traits in Holstein cows managed in a hot and humid environment. Lactating cows (n = 300) exposed to a heat stress environment were genotyped using a medium-density array including 53,218 SNPs. A genome-wide association study (GWAS) detected six SNPs associated with total milk yield (MY305) that surpassed multiple testing (p < 1.14 × 10−6). These SNPs were further validated in 216 Holstein cows from two independent populations that were genotyped using the TaqMan bi-allelic discrimination method and qPCR. In these cows, only the SNPs rs8193046, rs43410971, and rs382039214, within the genes TLR4, GRM8, and SMAD3, respectively, were associated (p < 0.05) with MY305, rectal temperature (RT), and respiratory rate. Interestingly, these variables improved as the number of favorable genotypes of the SNPs increased from 0 to 3. In addition, a regression analysis detected RT as a significant predictor (R2 = 0.362) for MY305 in cows with >1 favorable genotype, suggesting this close relationship was influenced by genetic markers. In conclusion, SNPs in the genes TLR4, GRM8, and SMAD3 appear to be involved in the molecular mechanism that regulates milk production in cows under heat-stressed conditions. These SNPs are proposed as thermotolerance genetic markers for a selection program to improve the milk performance of lactating Holstein cows managed in a semiarid environment.

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Section: Discussionmentioning

confidence: 99%

Genetic Markers Associated with Milk Production and Thermotolerance in Holstein Dairy Cows Managed in a Heat-Stressed Environment

Zamorano‐Algandar

Medrano

Thomas³

et al. 2023

Biology

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“…These climate problems have been discussed for a very long time. The Earth's temperature has risen by around 0.8°C over the past century, according to Assessment Reports 5 (AR5) of the Intergovernmental Panel on Climate Change (IPCC) (Rajamanickam et al, 2022). According to the report, global temperatures are predicted to rise by 1.8 to 4°C by the end of 2100 compared to the mean temperature between 1980 and 1999.…”

Section: Literature Reviewmentioning

confidence: 99%

Strategy For The Shipping Decarbonisation Using Marine Diesel Oil

Kurniasih,

Runadi,

Amma

2023

cset

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Climate change has become a global problem. Transportation is one of the contributors to the problem of increasing carbon emissions. The world of shipping, as the most significant mode of transportation of goods worldwide, contributes to increasing carbon emissions. Greenhouse Gas Emission has led IMO to participate in implementing policies related to decarbonization in the maritime world, which began in 2020. This research aims to understand the use of Marine Diesel Oil as one of the strategies implemented to reduce the impact of carbon emissions. This study uses a qualitative research methodology using primary data based on observations on board and secondary data from reputable international journals. In addition, data analysis uses the SWOT matrix. The results of this study are to determine the strengths and weaknesses of using MDO, as well as opportunities and threats to using MDO in Emission Control Areas. The hope is that ECA can be expanded, especially in world shipping lanes, to minimize the impact of carbon emissions. In addition, more in-depth research on decarbonization in the maritime industry and the port area can be carried out.

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“…A recent study conducted on functional response of bovine monocyte derived macrophages over thermal and Lipopolysaccharide (LPS) induced stress challenge indicates upregulation of heat shock protein 70 (HSP 70) gene and downregulation of cell signaling, i.e., Toll-like receptor 4 (TLR4) alteration in functional responses like autophagy, phagocytosis, and oxidative ability. Thus, during thermal stress, dairy cattle may be more susceptible to diseases due to dysregulation of macrophage function caused by thermal cum LPS stress [12]. After an in vivo heat challenge, high immune responders (based on their breeding values for antibody and cell-mediated immune responses) outperformed average and low responders in terms of HSP 70 concentration and cell proliferation.…”

Section: Introductionmentioning

confidence: 99%

The Impact of Heat Stress on Immune Status of Dairy Cattle and Strategies to Ameliorate the Negative Effects

Gupta

Sharma

Joy

et al. 2022

Animals

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Heat stress (HS) is well known to influence animal health and livestock productivity negatively. Heat stress is a multi-billion-dollar global problem. It impairs animal performance during summer when animals are exposed to high ambient temperatures, direct and indirect solar radiations, and humidity. While significant developments have been achieved over the last few decades to mitigate the negative impact of HS, such as physical modification of the environment to protect the animals from direct heat, HS remains a significant challenge for the dairy industry compromising dairy cattle health and welfare. In such a scenario, it is essential to have a thorough understanding of how the immune system of dairy cattle responds to HS and identify the variable responses among the animals. This understanding could help to identify heat-resilient dairy animals for breeding and may lead to the development of climate resilient breeds in the future to support sustainable dairy cattle production. There are sufficient data demonstrating the impact of increased temperature and humidity on endocrine responses to HS in dairy cattle, especially changes in concentration of hormones like prolactin and cortisol, which also provide an indication of the likely im-pact on the immune system. In this paper, we review the recent research on the impact of HS on immunity of calves during early life to adult lactating and dry cows. Additionally, different strategies for amelioration of negative effects of HS have been presented.

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Thermal cum lipopolysaccharide-induced stress challenge downregulates functional response of bovine monocyte-derived macrophages

Cited by 3 publications

References 50 publications

Genetic Markers Associated with Milk Production and Thermotolerance in Holstein Dairy Cows Managed in a Heat-Stressed Environment

Genetic Markers Associated with Milk Production and Thermotolerance in Holstein Dairy Cows Managed in a Heat-Stressed Environment

Strategy For The Shipping Decarbonisation Using Marine Diesel Oil

The Impact of Heat Stress on Immune Status of Dairy Cattle and Strategies to Ameliorate the Negative Effects

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