Thermal characterization of highly exothermic flash chemistry in a continuous flow calorimeter

Abstract

A key parameter for reactor design and safety evaluation is the reaction enthalpy (ΔHr). Flash chemistry is a field of chemical synthesis where fast reactions are performed in a precise...

Rapid production of the anaesthetic mepivacaine through continuous, portable technology

“…A continuous flow setup, with its highly efficient heat transfer and smaller reactor volumes, could offer a practical solution and could be tested with N -methylpipecolinate ( 4b ). 30–33…”

“…A continuous flow setup, with its highly efficient heat transfer and smaller reactor volumes, could offer a practical solution and could be tested with N-methylpipecolinate (4b). [30][31][32][33] With our system, the use of hexane for the lithiation step (entries 1 and 2, Table 3) enabled such a reaction to be carried out at room temperature; however, the required solvent exchange from hexane to 2-MeTHF to carry out the coupling of the Li-amide with 4b appeared problematic for its transposition to flow. In batch, this is a straightforward task that only requires evaporation and subsequent solvent addition.…”

Design and characterization of a flow reaction calorimeter based on FlowPlate® Lab and Peltier elements

“…10 Concerning calorimetry using microreactors, three basic concepts prevail for technical realization: optical measurements using infrared cameras, [11][12][13][14][15] energy balance based on temperature measurements, 9,16 and heat flux measurements using the thermoelectric effect. [17][18][19][20][21][22][23][24][25][26] Although several flow calorimeters have been developed using these concepts or combinations of them, only a few are commercially available. An example for a commercially available flow calorimeter is provided by Fluitec, Neftenbach, Switzerland.…”