Thermal characterization of dried extract of medicinal plant by DSC and analytical techniques

Fernandes, Felipe Hugo Alencar; Santana, Cleildo P.; Santos, Ravely Lucena; Correia, Lidiane Pinto; Conceição, Marta Maria da; Macêdo, Rui Oliveira; Medeiros, Ana Cláudia Dantas de

doi:10.1007/s10973-012-2807-3

Cited by 70 publications

(33 citation statements)

References 13 publications

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“…Other characteristic parameter attributed a chromatography is purity determination, but actually no DSC technique has been also used for this finality [36]. Previously, Araújo et al determined the purity by DSC for samples melting of which is complete.…”

Section: Resultsmentioning

confidence: 99%

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Thermal characterization of some guanylhydrazones by thermal and nonthermal techniques

galvão

Brito

Dantas

et al. 2014

J Therm Anal Calorim

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2-[(3,5-di-tert-butyl-4-hydroxyphenyl)methylene]-hydrazinecarboximidamide (WE010), 2-([1,1 0 -biphenyl]-4-ylmethylene)-hydrazinecarboximidamide (WE014), and 2-[(3,4-dichlorophenyl)methylene]-hydrazinecarboximidamide (WE017) are guanylhydrazone derivatives widely studied biologically and chemically; however, there are no studies regarding their thermal behaviors. The present study aims to apply the thermal analyses: differential scanning calorimetry (DSC), differential scanning calorimetry coupled to the photovisual system (DSC-photovisual), and thermogravimetry (TG), to characterize the guanylhydrazones, as well as HPLC and FTIR. The DSC curve of WE010 shows a melting process with T onset at 190°C and peak at 193.5°C (DH 41.0 J g -1 ). Due to the symmetry of the melting peaks obtained by DSC, it is possible to calculate the purity of the sample (98.87 %). The DSC curve of WE014 shows the melting process in the range of 208-213°C, with a melting peak at 211°C (DH 61 J g -1 ).The DSC curve of WE017 showed T onset at 215°C and peak temperature of 219°C (DH 55 J g -1 ). The TG curve of WE010, WE014, and WE017 presents initial decomposition temperatures of 186.95, 197.31, and 195.44°C, respectively. The DSC-photovisual confirmed the results of DSC and TG. The HPLC determined the purities of the samples and confirmed the results of DSC. The FTIR confirmed the thermal data. Thus, the use of thermal analysis is an important tool for the characterization of molecules with therapeutic potential contributing to the characterization and evaluation of their stability as well as nonthermal technique with complementary tool.

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Section: Resultsmentioning

confidence: 99%

“…Other analytic non-thermal techniques have been used to identify and quantify samples with HPLC and FTIR [35,36]. However, there are no studies with these guanylhydrazones by techniques cited above.…”

Section: Introductionmentioning

confidence: 99%

Thermal characterization of some guanylhydrazones by thermal and nonthermal techniques

galvão

Brito

Dantas

et al. 2014

J Therm Anal Calorim

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“…Herbal medicine powder, its products and extracts have been characterized by analytical methods. Scanning electron microscopy (SEM) is used to characterize the morphology and particle size of herbal medicine powder [12,13]; thermal analysis such as thermogravimetry (TG) and differential thermal analysis (DTA) together with pyrolysis coupled to gas chromatography/mass spectrometry is employed to evaluate the quality of pharmaceuticals [14][15][16], as well as atomized extracts of herbal medicine like E. mulungu [17] and distinct brands and batches of Cymbopogon citratus teas [18]. Figure 1 shows the micrographs from samples CAR 01, 02 and 03.…”

Section: Thermal Decomposition Kinetic Interpretationmentioning

confidence: 99%

Herbal medicine physical quality evaluation by thermal analysis using adapted Ozawa method

Correia

Procópio

Santana

et al. 2015

J Therm Anal Calorim

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The aim of this study was to evaluate the physical quality of Tabebuia caraiba (Mart.) Bur. powder, separately in three batches of different particle sizes, through the adapted Ozawa method. The Ozawa model was used for thermogravimetry (TG) data analysis in dynamic synthetic air and nitrogen atmospheres in different heating rates (5, 10, 20 and 40°C min -1 ). The software TA-50 was used to data treatment. Kinetic data showed different values of activation energy and same reaction order according to the particle powder sample size in a specific model (derivative or tangent) of data treatment. The difference factor (F 1 ) was used to compare the parallelism line of the samples constructed by Ozawa graphs. Different kinetic results discriminate the particles size of the samples. TG technique allowed discriminating different particle sizes of herbal medicine powder.

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“…This method is used for the thermal characterization of all solid and semi-solid substances that are used in the pharmaceutical industry [2,3].…”

Section: Introductionmentioning

confidence: 99%

Investigation of Thermal Behavior of Nigellae Sativae Semen from Different Types of Extracts

Toma¹,

Tiťa²,

Oláh³

et al. 2018

Studia UBB Chemia

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ABSTRACT. Thermal methods have an important applicability in the pharmaceutical field, such as raw material control, purity determination, thermal stability determination, substance compatibility, qualitative and quantitative analysis of drugs, etc. Data on substance stability are obtained from the analysis of thermal decomposition determinations that occur both under isothermal conditions and under non-isothermal conditions. Thermogravimetry and derived thermogravimetry (TG / DTG) and differential scanning calorimetry (DSC) that are used to study the compatibility of the active substances and excipients have become increasingly important, because identify possible interactions between these components of the drugs. These thermoanalytic techniques have been used to study the behavior of a Nigella sativa semen glycerin macerate. To obtain tinctures and glycerin macerates, the European Pharmacopoeia methodology was followed. The thermoanalytic curves were recorded in a dynamic atmosphere of nitrogen and air (20 ml / min). The sample heating rate was 10 ° C / min. Thermal TG / DTG and DSC methods were applied in the temperature range of 25-1000 ° C.

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Thermal characterization of dried extract of medicinal plant by DSC and analytical techniques

Cited by 70 publications

References 13 publications

Thermal characterization of some guanylhydrazones by thermal and nonthermal techniques

Thermal characterization of some guanylhydrazones by thermal and nonthermal techniques

Herbal medicine physical quality evaluation by thermal analysis using adapted Ozawa method

Investigation of Thermal Behavior of Nigellae Sativae Semen from Different Types of Extracts

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