Thermal and spectroscopic analysis of florfenicol irradiated in the solid-state

Marciniec, B; Stawny, Maciej; Hofman, Magdalena; Naskrent, Marek

doi:10.1007/s10973-008-9137-5

Cited by 12 publications

(7 citation statements)

References 14 publications

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“…The first one started at around 170 °C while the second step occured at around 220 °C and continued until all sample was completely degraded after 600 °C [46] . Similaly, two stages of mass loss were observed at around 150 °C and 250 °C in TGA curve of Florfenicol [47] . TGA profile of DOX‐FLO@AgNPs showed a gradual mass loss between 100 °C and 500 °C and a rapid weight reduction at around 600 °C could be due to both the dehydration and the decomposition of organics compounds.…”

Section: Resultsmentioning

confidence: 93%

“…[46] Similaly, two stages of mass loss were observed at around 150 °C and 250 °C in TGA curve of Florfenicol. [47] TGA profile of DOX-FLO@AgNPs showed a gradual mass loss between 100 °C and 500 °C and a rapid weight reduction at around 600 °C could be due to both the dehydration and the decomposition of organics compounds. The higher decomposed temperature of the DOX-FLO@AgNPs, compared to the raw materials, could be explained by the interaction of DOX/ FLO with the Alginate/Chitosan nanocarrier making the synthesized particles more thermal stable.…”

Section: Chemistryselectmentioning

confidence: 99%

“…[48,46] The exothermic peaks observed at around 220 °C for Doxycycline, 300 °C for Chitosan and 330 °C for Alginate corresponding to thermal decomposition of these compounds. [47,49,45,37] . For DOX-FLO@AgNPs nanosystem, DTA curve showed some endothermic peaks at around 130 °C, 230 °C, 520 °C and one strong exothermic peak from 525 °C up to 620 °C which were in agreement with TGA analysis.…”

Section: Chemistryselectmentioning

confidence: 99%

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Co‐delivery of Doxycycline, Florfenicol and Silver Nanoparticles using Alginate/Chitosan Nanocarriers

Phan

Nguyen

et al. 2022

ChemistrySelect

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The overuse of antibiotics has led to the sharp increase of antibiotic-resistant bacteria that can consequently transmit and cause hard-to-cure human diseases. To deal with this problem, nano drug delivery systems have been widely researched. This report focuses on developing an Alginate/Chitosan-based nanosystem that carried simultaneously Doxycycline (DOX), Florfenicol (FLO), and silver nanoparticles (AgNPs). The optimal Alginate/Chitosan ratio of 3 : 2 (w/w) created the most stable nanocarrier system. The fabricated DOX-FLO@AgNPs had a spherical shape with a small size of about 20 nm and could release slowly DOX and FLO at pH of 7.4 and 5.0. In vitro drug release kinetics of DOX and FLO from DOX-FLO@AgNPs fitted best to the Weibull or Higuchi model by the mechanism of the Fickian or non-Fickian diffusion. The nanosystem of DOX-FLO@AgNPs had much lower IC 50 of 0.012 � 0.001 and 0.08 � 0.005 μg/mL against E.coli and B.subtilis, respectively, than the conventional form. The FIC 50 value of smaller than 0.5 μg/mL for 5 out of 6 tested bacteria also indicated the synergistic effect of each component in this antibiotic combination. Moreover, the cytotoxicity assay confirmed the viability of 96.4 � 2.3 % for vero cell line that exposured to the treatment dose. Therefore, these findings strongly suggest that the DOX-FLO@AgNPs formulation is promising for combined antibiotic drug delivery and silver nanoparticles, and will be worth investigating for further in vivo potential.

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Section: Resultsmentioning

confidence: 93%

Section: Chemistryselectmentioning

confidence: 99%

Section: Chemistryselectmentioning

confidence: 99%

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Co‐delivery of Doxycycline, Florfenicol and Silver Nanoparticles using Alginate/Chitosan Nanocarriers

Phan

Nguyen

et al. 2022

ChemistrySelect

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“…The methodology of measurements by the, FT-IR, EPR, was the same as described for florfenicol investigation 19 .…”

Section: Ph Measurementsmentioning

confidence: 99%

The effect of ionizing radiation on metoprolol

Ogrodowczyk

Marciniec

Czwajda

2012

Drug Development and Industrial Pharmacy

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The influence of ionising radiation on physico-chemical properties of metoprolol tartrate (MT) in solid phase was studied. The compound was irradiated by radiation produced by a beam of high-energy electrons in an accelerator, in doses from 25 to 400 kGy, and the possible changes in the samples were detected by organoleptic analysis (colour, forms, clarity), chromatographic and spectrometric methods. Already at the standard sterilisation dose of 25 kGy, the presence of free radicals (0.3764 × 10(16) spin/g) and a decrease in the melting point by 1°C were noted. At higher doses of irradiation products of radiolysis appeared (100 kGy) and the colour was changed from white to pale cream (200 kGy). Our observation was that with increasing mass loss of MT after irradiation with 100, 200 and 400 kGy, the concentration of free radicals increased from 1.0330 to 1.6869 × 10(16) spin/g. The radiolytic yield of total radiolysis was 4.54 × 10(7) mol/J for 100 kGy, 7.42 × 10(7) mol/J for 200 kGy and 4.74 × 10(7) mol/J for 400 kGy. No significant changes were observed in the character of FT-IR spectra, but in UV an increase in intensity of the band at the analytical wavelength was noted. As follows from the results MT shows high radiochemical stability for the typical sterilisation doses 25-50 kGy, and will probably be able to be sterilised by radiation in the dose of 25 kGy.

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“…Differential Scanning Calorimetry (DSC) results for selected formulations are shown in Supplementary material (Figure SM3) . FF fusion peak can be observed at 152 C. 42,46 The glass transition temperature of PLGA is 37e38 C. 47 The formulation P50 presents a fusion peak at 155 C and can be associated with crystalline FF. The difference with pure FF is possibly related to interactions with the polymeric matrix.…”

Section: Resultsmentioning

confidence: 99%

In situ Formed Implants, Based on PLGA and Eudragit Blends, for Novel Florfenicol Controlled Release Formulations

Karp

Turino

Helbling

et al. 2021

Journal of Pharmaceutical Sciences

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Drug controlled release technologies (DCRTs) represent an opportunity for designing new therapies. Main objectives are dose number optimization and secondary effects reduction to improve the level of patient/client acceptance. The present work studies DCRTs based in blended polymeric implants for single dose and long-term therapies of florfenicol (FF), a broad spectrum antibiotic. Polymers used were PLGA and Eudragit E100/S100 types. Eudragit/PLGA and FF/PLGA ratios were the main studied factors in terms of encapsulation efficiencies (EEs) and drug release profiles. In addition, morphological and physicochemical characterization were carried out. EEs were of 50e100% depending on formulation composition, and the FF releasing rate was increased or diminished when E100 or S100 were added, respectively. PLGA hydrolytic cleavage products possibly affect Eudragit solubility and matrix stability. Different mathematical models were used for better understanding and simulating release processes. Implants maintained the antimicrobial activity against Pseudomonas aeruginosa up to 12 days on agar plates. The developed DCRTs represents a suitable alternative for florfenicol long-term therapies.

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Thermal and spectroscopic analysis of florfenicol irradiated in the solid-state

Cited by 12 publications

References 14 publications

Co‐delivery of Doxycycline, Florfenicol and Silver Nanoparticles using Alginate/Chitosan Nanocarriers

Co‐delivery of Doxycycline, Florfenicol and Silver Nanoparticles using Alginate/Chitosan Nanocarriers

The effect of ionizing radiation on metoprolol

In situ Formed Implants, Based on PLGA and Eudragit Blends, for Novel Florfenicol Controlled Release Formulations

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